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日用化学工业（中英文）

日用化学工业 ›› 2017, Vol. 47 ›› Issue (2): 87-89.doi: 10.13218/j.cnki.csdc.2017.02.006

• 开发与应用 • 上一篇    下一篇

当归净油抗衰老及抗炎祛痘功效的体外实验研究

王玥1,2,3, 于海园2, 施雁勤1, 潘仙华1, 卢艳花2, 曹平3   

  1. 1.上海应用技术大学,上海 201418;
    2.华东理工大学 生物反应器工程国家重点实验室,上海 200237;
    3.上海家化集团有限公司,上海 200082
  • 收稿日期:2016-10-28 出版日期:2017-02-22 发布日期:2019-03-19
  • 通讯作者: 曹 平,高级工程师,电话:(021)65456400,E-mail:caoping@jahwa.com.cn。
  • 作者简介:王 玥(1978-),女,上海人,讲师,博士,电话:(021)64471311,E-mail:wangyue@sriffi.com。   
  • 基金资助:
    教育和科研协同创新计划——上海市香料香精及化妆品协同创新中心资助项目(1021ZK162001)

In vitro test for examination of anti-senility and anti-inflammatory acne effects of absolute oil from Angelica sinensis (Oliv.) Diels

WANG Yue1,2,3, YU Hai-yuan2, SHI Yan-qin1, PAN Xian-hua1, LU Yan-hua2, CAO Ping3   

  1. 1.Shanghai Institute of Technology,Shanghai 201418,China;
    2.State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China;
    3.Shanghai Jahwa Group Co.,Ltd.,Shanghai 200082,China
  • Received:2016-10-28 Online:2017-02-22 Published:2019-03-19

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摘要： 通过人真皮成纤维细胞(HDF-a)模型,考察了当归净油对细胞分泌Ⅰ型胶原蛋白(Col-Ⅰ)的影响。结果表明,当归净油在最大安全质量浓度25 mg/L时,能有效增加HDF-a细胞分泌Col-Ⅰ达33.5%。利用痤疮丙酸杆菌刺激人急性单核细胞THP-1,建立了特异性痤疮炎症细胞模型,考察当归净油对细胞分泌炎症因子人白细胞介素1β (IL-1β)的影响。结果表明,当归净油最大安全质量浓度为12.5 mg/L,此时对痤疮丙酸杆菌诱导的THP-1细胞炎症因子IL-1β 分泌抑制率高达94.51%,当质量浓度减半为6.25 mg/L时,抑制率为64.34%。当归净油作为一种芳香性中草药,有望成为抗衰老及抗炎祛痘的个人护理天然原料,在化妆品中得到进一步开发和利用。

关键词: 化妆品添加剂, 当归, 抗衰老, 抗炎祛痘, 植物天然香料

Abstract: Via a model of human dermal fibroblasts-adult (HDF-a),effects of Angelica sinensis absolute oil (ASO) on the secretion of collagen type Ⅰ (Col-Ⅰ) by the HDF-a cells were examined.Results showed that when the ASO is at its maximum safety mass concentration for the HDF-a cells 25 mg/L,the secretion of Col-Ⅰ in HDF-a cells can be effectively increased by 33.5%.In addition,an inflammatory acne model was established by stimulating human acute mononuclear cells THP-1 cells with Propionibacterium acnes (P.acnes).Results showed that when ASO is at its maximum safety mass concentration for the THP-1 cells 12.5 mg/L,the ASO can inhibit the release of inflammatory cytokines IL-1β from P.acnes treated THP-1 cells by 94.51%.When the mass concentration is halved to 6.25 mg/L,the ASO still can significantly inhibit IL-1β secretion by 64.34%.Hence,ASO is a natural plant perfume raw material that displays anti-senility and anti-inflammatory acne effects in personal care activities and is expected to be further developed and applied in cosmetics.

Key words: cosmetic additive, Angelica sinensis, anti-senility, anti-inflammatory acne, perfume plants

中图分类号: 

  • TQ658