日用化学工业(中英文) ›› 2023, Vol. 53 ›› Issue (8): 873-881.doi: 10.3969/j.issn.2097-2806.2023.08.003
收稿日期:
2023-08-01
出版日期:
2023-08-22
发布日期:
2023-08-28
通讯作者:
常宽,王靖
基金资助:
Chen Xianqi1,Ma Ling2,Chen Timson2,Chang Kuan1,*(),Wang Jing1,*(
)
Received:
2023-08-01
Online:
2023-08-22
Published:
2023-08-28
Contact:
Kuan Chang,Jing Wang
摘要:
随着科技发展和人们生活水平的改善,大众的审美亦逐渐提高,人们对于外貌尤其是头发方面愈加关注,防脱、生发也成为了大家关注的焦点。脱发,是指头发脱落的一种生理现象,分为生理性脱发和病理性脱发。毛囊(HF)在毛发形态的形成和生长中起着重要作用,不同的细胞信号通路和生长因子参与调控毛囊生长周期。本文基于人真皮乳头细胞(HDPCs)模型,综述了几种体外应激诱导模型,通过模型中标记物的变化,以此来考察和筛选防脱原料的功效。此外,还列举了几种常见的植物防脱原料,并概括其在毛囊中的作用机理,希望为今后防脱生发理论的研究和植物防脱原料开发提供参考。
中图分类号:
陈仙祺,马玲,陈殿松,常宽,王靖. 头发与头皮护理的科学基础(Ⅷ)——防脱生发体外评价方法以及植物防脱原料研究进展[J]. 日用化学工业(中英文), 2023, 53(8): 873-881.
Chen Xianqi,Ma Ling,Chen Timson,Chang Kuan,Wang Jing. Scientific foundations of hair and scalp care (Ⅷ)Method for in vitro evaluation of hair growth prevention and research progress of plant anti-stripping raw materials[J]. China Surfactant Detergent & Cosmetics, 2023, 53(8): 873-881.
表1
毛囊生长因子及其作用"
生长因子 | 作用 |
---|---|
表皮生长因子(EGF) | 结合ErbB1受体诱导ORS细胞内DNA合成,并将毛球细胞分化为ORS细胞[ |
转化生长因子-β(TGF-β) | 在毛囊周期的退行期起着重要的调节作用,毛囊细胞的表皮修复依赖于TGF-β1的表达[ |
胰岛素样生长因子-1(IGF-1) | 是一种多功能的调节生长因子,控制细胞增殖和毛囊细胞的生存[ |
肝细胞生长因子(HGF) | 调节上皮角化细胞与HDPCs的相互作用;主要参与毛囊形态发生过程中角质形成细胞的增殖、分化和凋亡[ |
角化细胞生长因子(KGF) | 可诱导毛囊增殖和祖细胞分化,促进上皮化和创面愈合,是皮肤再生的关键决定因子[ |
血管内皮生长因子(VEGF) | 诱导毛细血管网络的增殖;在毛囊外根鞘(Outer root sheath, ORS)中过表达,促进毛发再生[ |
成纤维生长因子(FGF) | 在头发发育过程中,HDPCs增加了FGF的表达;外源性FGF7/FGF10也能刺激毛囊角质形成细胞的增殖[ |
白细胞介素类(ILs) | ILs刺激会引起毛乳头变形收缩、毛母质细胞空泡异常、内根鞘和毛球部角化异常等生长期毛囊营养不良现象,抑制毛囊和毛发的生长[ |
表2
中草药提取物及其防脱发机理"
名称 | 防脱机理 | 参考文献 |
---|---|---|
积雪草 | 促进HDPCs增殖,上调VEGF | [ |
侧柏叶 | 促进HDPCs增殖,上调Wnt10b、β-catenin蛋白、IGF-1、VEGF | [ |
红花 | 促进HDPCs增殖,上调VEGF、KGF,下调TGF-β1 | [ |
何首乌 | 抑制5α-还原酶,上调FGF、HGF、β-catenin和Shh蛋白 | [ |
老鹳草 | 促进HDPCs增殖,上调HGF,下调TGF-β1 | [ |
女贞子 | 抑制5α-还原酶 | [ |
苦参 | 抑制5α-还原酶,上调IGF-1和KGF | [ |
三七 | 抑制5α-还原酶,促进HDPCs增殖 | [ |
当归 | 上调Bcl-2/Bax比值,降低退行期TNF-α水平 | [ |
斑叶芒 | 下调TGF-β1,上调HGF和β-catenin蛋白 | [ |
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