黄连上清胶囊联合抗敏牙膏治疗慢性牙周炎效果及对Th17/Treg、复发的影响

doi:10.3969/j.issn.1001-1803.2022.05.012

摘要/Abstract

摘要：

研究黄连上清胶囊联合高露洁专效抗敏牙膏治疗慢性牙周炎（CP）效果及对辅助性T细胞17/调节性T细胞（Th17/Treg）、复发的影响。选取CP患者134例,采用简单随机化法分为对照组（n=67）和观察组（n=67）,分别给予高露洁专效抗敏牙膏、黄连上清胶囊+高露洁专效抗敏牙膏。观察两组治疗效果、不良反应、复发情况及治疗前后牙周袋深度（PD）、牙龈指数（GI）、龈沟出血指数（SBI）、吹气刺激敏感值（BST）、Th17/Treg细胞水平、牙龈卟啉单胞菌（PG）、乳酸杆菌（LB）。结果显示,治疗4周后,观察组治疗总有效率高于对照组（P<0.05）;治疗4周后观察组PD、PLI、GI、BST值低于对照组（P<0.05）;治疗4周后观察组Th17、Treg细胞及PG、LB水平低于对照组（P<0.05）;两组不良反应及复发率比较差异无统计学意义（P>0.05）。黄连上清胶囊联合高露洁专效抗敏牙膏有利于下调CP患者Th17/Treg细胞水平,阻止细菌定植,改善牙周症状,提高治疗效果,且安全性高。

关键词: 牙膏, 抗敏, 慢性牙周炎, 黄连上清胶囊, 复发

Abstract:

The study aimed to investigate the effect of Huanglian Shangqing Capsule combined with Colgate special anti-allergic toothpaste on the treatment of chronic periodontitis （CP） and its effect on helper T cell 17/regulatory T cell （Th17/Treg） and recurrence. A total of 134 CP patients in the Hospital from October 2019 to October 2021 were selected and divided into the control group （n=67） and the observation group （n=67） by simple randomization, and were given Colgate special anti-allergic toothpaste and Shangqing Capsule+Colgate special anti-allergic toothpaste, respectively. The treatment effect, adverse reactions, recurrence, and periodontal pocket depth （PD）, gingival index （GI）, gingival crevicular bleeding index （SBI）, insufflation sensitivity （BST）, Th17/Treg cell levels, Porphyromonas gingivalis （PG）, and Lactobacillus （LB） before and after treatment were observed in the two groups. After 4 weeks of treatment, the total effective rate of the observation group is higher than that of the control group （P<0.05）. The PD, PLI, GI and BST values of the observation group are lower than those of the control group （P<0.05）. The levels of Th17/Treg cells, PG and LB in the observation group are lower than those in the control group （P<0.05）. There is no significant difference in adverse reactions and recurrence rates between the two groups （P>0.05）. Huanglian Shangqing Capsules combined with Colgate anti-allergic toothpaste is beneficial to down-regulate the level of Th17/Treg cells in CP patients, prevent bacterial colonization, improve periodontal symptoms, and improve the therapeutic effect, and it has high safety.

Key words: toothpaste, anti-allergy, chronic periodontitis, Huanglian Shangqing Capsule, recurrence

中图分类号:

TQ658

蒋菁,顾长明. 黄连上清胶囊联合抗敏牙膏治疗慢性牙周炎效果及对Th17/Treg、复发的影响[J]. 日用化学工业, 2022, 52(5): 539-544.

Jiang Jing,Gu Changming. Effect of Huanglian Shangqing Capsules combined with anti-allergic toothpaste in the treatment of chronic periodontitis[J]. China Surfactant Detergent & Cosmetics, 2022, 52(5): 539-544.

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组别	例数	治愈	好转	无效	总有效率
观察组	67	43（64.18%）	20（29.85%）	4（5.97%）	63（94.03%）
对照组	67	24（35.82%）	27（40.30%）	16（23.88%）	51（76.12%）
χ²					8.463
P					0.004

时间	组别	例数	PD/mm	SBI/分	GI/分	BST值
治疗前	观察组	67	5.50±0.96	3.16±0.24	2.41±0.23	1.88±0.25
	对照组	67	5.38±1.24	3.22±0.21	2.36±0.26	1.92±0.21
	t		0.626	1.540	1.180	1.003
	P		0.532	0.126	0.241	0.318
治疗4周后	观察组	67	2.91±0.46	1.15±0.12	0.87±0.08	0.87±0.12
	对照组	67	3.88±0.52	1.56±0.18	1.25±0.11	1.13±0.16
	t		11.436	15.513	22.868	10.641
	P		<0.001	<0.001	<0.001	<0.001

组别	例数	Th17含量/%		Treg含量/%
组别	例数	治疗前	治疗4周后	治疗前	治疗4周后
观察组	67	2.55±0.42	1.33±0.21	5.44±0.81	4.11±0.65
对照组	67	2.42±0.46	1.58±0.23	5.51±0.78	4.88±0.82
t		1.708	6.570	0.510	6.023
P		0.090	<0.001	0.611	<0.001

组别	例数	PG/（CFU/mL）		LB×10⁶
组别	例数	治疗前	治疗4周后	治疗前	治疗4周后
观察组	67	3.52±0.25	1.79±0.30	7.40±1.44	6.03±0.98
对照组	67	3.60±0.22	2.01±0.34	7.29±1.56	6.89±1.02
t		1.966	3.971	0.424	4.977
P		0.051	<0.001	0.672	<0.001

组别	例数	呕吐	口有金属味	恶心	总发生率
观察组	67	1（1.49%）	3（4.48%）	2（2.99%）	6（8.96%）
对照组	67	2（2.99%）	1（1.49%）	1（1.49%）	4（5.97%）
χ²					0.432
P					0.511