党参复方提取物的活性及洗发液制备与质量研究

doi:10.3969/j.issn.1001-1803.2021.05.008

摘要/Abstract

摘要：

以党参复方提取物为主要活性成分,研制了一款中药复方洗发液。采用硝酸铝显色法测定党参复方总黄酮含量;通过体外抗氧化试验研究党参复方的抗氧化能力;筛选以氨基酸表面活性剂为主的基本配方,依据GB/T 29679–2013《洗发液、洗发膏》进行评价。结果显示,党参复方提取液中的总黄酮得率为8.32%;抗氧化试验表明党参复方清除DPPH自由基、清除羟自由基、总抗氧化能力在一定范围随着总黄酮质量浓度的增大而增强;性能评价表明制备的洗发液符合国家标准。党参复方洗发液是一款成分安全、抗氧化能力强、稳定性好的产品。

关键词: 党参复方, 中药洗发液, 氨基酸表面活性剂, 抗氧化

Abstract:

A shampoo was prepared in which radix codonopsis extract was the major active ingredient. The content of total flavonoids in radix codonopsis extract was 8.32% as determined by Al（NO₃） ₃ colorimetry. The in vitro antioxidant ability of radix codonopsis extract was studied. The results showed that the abilities to clear DPPH and hydroxyl radicals and the total antioxidant capacity increased with the increase of mass concentration of total flavonoids. The formulation with an amino acid surfactant as the main surfactant was optimized and evaluated according to GB/T 29679–2013 “Hair shampoo, cream shampoo”. The radix codonopsis shampoo was a product with safe ingredients and good antioxidant capacity and stability.

Key words: radix codonopsis composite, Chinese-medicine shampoo, amino acid surfactant, antioxidant

中图分类号:

TQ423

贾颖,赵婧,萧猷勤. 党参复方提取物的活性及洗发液制备与质量研究[J]. 日用化学工业, 2021, 51(5): 421-427.

JIA Ying,ZHAO Jing,XIAO You-qin. Study on the activity of radix codonopsis extract and the preparation and quality of a shampoo[J]. China Surfactant Detergent & Cosmetics, 2021, 51(5): 421-427.

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参考文献 9

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项目	质地	外观	易冲洗程度	去油污能力	梳理性	整体蓬松感	耐热性	耐寒性
分值/分	8~10	8~10	8~10	8~10	8~10	8~10	20	20
描述	细腻	清澈明亮	很容易	强	非常顺滑	轻盈蓬松	无分层	无分层
分值/分	5~7	5~7	5~7	5~7	5~7	5~7	0	0
描述	较为细腻	明亮	较为容易	微弱残留	顺滑	较为扁塌	分层	分层
分值/分	<5	<5	<5	<5	<5	<5	分层	分层
描述	粗糙且分散性差	暗淡无光泽	很难	弱	很涩	厚重	分层	分层

	A							RSD/%
	1	2	3	4	5	6	平均值	RSD/%
重复性	0.560	0.566	0.574	0.557	0.569	0.576	0.567	1.33
精密度	0.555	0.554	0.554	0.557	0.554	0.556	0.555	0.23
稳定性	0.566	0.572	0.583	0.591	0.586	0.605	0.584	2.38

	ρ（总黄酮）/（mg·mL^-1）
	0.28	0.37	0.46	0.56	0.65
As	0.338	0.318	0.314	0.297	0.250
	0.337	0.319	0.307	0.297	0.252
	0.336	0.318	0.311	0.299	0.251
平均值	0.337	0.318	0.311	0.298	0.251
Ac	0.471
DPPH自由基清除率/%	28.45	32.48	33.97	36.73	46.71

	ρ（总黄酮）/（mg·mL^-1）
	0.37	0.42	0.46	0.51	0.56
Bs	0.246	0.249	0.256	0.309	0.381
	0.246	0.249	0.255	0.309	0.381
	0.246	0.248	0.256	0.309	0.382
平均值	0.246	0.248	0.256	0.309	0.381
Bb	0.456
Bc	0.170
羟自由基清除率/%	26.57	27.13	29.95	48.60	73.89

	ρ（总黄酮）/（mg·mL^-1）
	0.37	0.42	0.46	0.51	0.56
第1组	0.927	1.023	1.107	1.229	1.296
第2组	0.939	1.037	1.121	1.233	1.32
第3组	0.938	1.037	1.122	1.235	1.322
平均值	0.935	1.032	1.117	1.232	1.313
FRAP值	1.597	1.765	1.910	2.108	2.246