化妆品经皮渗透研究进展——评价方法及促渗技术

doi:10.3969/j.issn.1001-1803.2020.11.010

摘要/Abstract

摘要：

对于化妆品中应用的经皮递送系统,列举常见的促渗方法,包括化学促渗技术、纳米技术（纳米乳液、纳米晶体、脂质体、类脂囊泡、微胶粒等）、物理促渗技术（离子导入、超声导入、微针）以及生物促渗技术等。对化妆品体外透皮吸收试验方法（体外扩散池法、数学模型、三维皮肤模型、液质联用、拉曼光谱）进行了简单介绍,并对化妆品经皮渗透方法进行了展望。

关键词: 经皮渗透, 评价方法, 3D皮肤, 液质联用, 促渗技术

Abstract:

For the transdermal delivery system used in cosmetics, the common methods for promoting penetration have been listed, including chemical permeation-enhancing techniques, nanotechnology （nanoemulsions, nanocrystals, liposomes, niosomes, micelles, etc.）, physical permeation-enhancing techniques （iontophoresis, ultrasonic introduction, and microneedle） and biological permeability-promoting technology. The testing methods of transdermal absorption of cosmetics in vitro （in-vitro diffusion cell method, mathematical model, three-dimensional skin model, LC-MS, and Raman spectroscopy） have been briefly introduced, and the future transdermal penetration methods of cosmetics have been prospected.

Key words: skin permeation, evaluation method, 3D skin, liquid chromatography-mass spectrometry, transdermal enhancement technique

中图分类号:

TQ658

杨曼丽,周明月,胡雪情,陈风,何聪芬,贾焱. 化妆品经皮渗透研究进展——评价方法及促渗技术[J]. 日用化学工业, 2020, 50(11): 793-798.

YANG Man-li,ZHOU Ming-yue,HU Xue-qing,CHEN Feng,HE Cong-fen,JIA Yan. Progress in research of skin permeability of cosmetics Evaluation method and enhancement technology[J]. China Surfactant Detergent & Cosmetics, 2020, 50(11): 793-798.

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