海洋来源的美白活性成分的研究进展

doi:10.3969/j.issn.1001-1803.2019.04.012

日用化学工业 ›› 2019, Vol. 49 ›› Issue (4): 264-268.doi: 10.3969/j.issn.1001-1803.2019.04.012

海洋来源的美白活性成分的研究进展

欧阳佩佩¹,廖雪华²,吴科锋^1,²,马晓鹂³()

^1. 广东医科大学海洋医药研究院,广东湛江 524023
^2. 广东医科大学广东天然药物研究与开发重点实验室,广东湛江 524023
^3. 广东医科大学附属医院,广东湛江 524001

收稿日期:2018-09-13 修回日期:2019-03-22 出版日期:2019-04-22 发布日期:2019-04-24
通讯作者: 马晓鹂
作者简介:欧阳佩佩（1994-）,女,江西人,硕士研究生,电话：13030197285,E-mail：1690423326@qq.com。
基金资助:
广东省自然科学基金资助项目(2018A030307001);湛江市财政资金科技专项竞争性分配项目(2017A06012);湛江市财政资金科技专项竞争性分配项目(2017A06012);湛江市财政资金科技专项竞争性分配项目(2017A06012)

Research progress on whitening active ingredients from marine sources

OUYANG Pei-pei¹,LIAO Xue-hua²,WU Ke-feng^1,²,MA Xiao-li³()

^1. Marine Biomedical Research, Guangdong Medical University, Zhanjiang, Guangdong 524023, China
^2. Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, Guangdong 524023, China
^3. Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China

Received:2018-09-13 Revised:2019-03-22 Online:2019-04-22 Published:2019-04-24
Contact: Xiao-li MA

摘要/Abstract

摘要：

概述了黑色素合成与信号转导途径,综述了海藻活性成分如多糖、多酚、类胡萝卜素和萜类化合物;海洋动物提取物如蛋白质、多肽和糖蛋白;以及海洋微生物中微藻、真菌和细菌的活性物质在美白方面的研究成果,并指出以这些活性成分为原料开发新型美白化妆品的市场前景。

关键词: 美白, 海洋, 黑色素, 活性成分

Abstract:

The synthesis and signal transduction pathway of melanin were summarized. The research results of seaweed active composition such as polysaccharides, polyphenols, carotenoids and terpenoids, marine animal extracts such as collagen, peptides and glycoproteins, and active substances of microalgae, marine fungi and bacteria in whitening were reviewed. It points out the market prospect of developing new whitening cosmetics based on these active ingredients.

Key words: whitening, marine, melanin, active ingredients

中图分类号:

TQ658

欧阳佩佩,廖雪华,吴科锋,马晓鹂. 海洋来源的美白活性成分的研究进展[J]. 日用化学工业, 2019, 49(4): 264-268.

OUYANG Pei-pei,LIAO Xue-hua,WU Ke-feng,MA Xiao-li. Research progress on whitening active ingredients from marine sources[J]. China Surfactant Detergent & Cosmetics, 2019, 49(4): 264-268.

图/表 1

表1

参考文献 35

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来源	美白活性成分	美白作用机制	化妆品应用范例
海洋植物	褐藻糖胶	激活ERK信号通路,下调MITF的表达,降低Tyr活性,抑制黑素生成	九美子深海藻净白控油洗面奶、碧奥泉海藻面膜、Nongnaka海藻物理防晒霜、水密码雪肌亮采面膜
	间苯三酚、虾青素	具有抗氧化性,抑制Tyr活性
	4-羟基苯乙醇	抑制蘑菇酪氨酸酶活性,降低黑色素含量
	dioxinodehydroeckol	激活PI3K/Akt信号通路,促进Akt的磷酸化,抑制MITF、Tyr、TRP-1和TRP-2的表达
	Octaphlorethol A	激活ERK信号通路,抑制黑素生成
	岩藻黄素	抑制MC1R和Tyr相关蛋白的mRNA表达,抵抗紫外线辐射引起的氧化应激
	sargahydroquinoic acid	通过cAMP/CREB通路和ERK信号转导途径抑制MITF表达
海洋动物	胶原蛋白	通过螯合铜离子来抑制Tyr活性	鱼胶原蛋白肽口服液肽饮、德国比曼塔鱼子酱胶原蛋白肽粉胶囊
	胶原肽	降低细胞内cAMP含量,从而抑制Tyr的表达,并缓解紫外线照射引起的体内氧化压力
	糖蛋白	促进ERK磷酸化,降低MITF、Tyr、TRP-1和TRP-2的蛋白表达水平
海洋微生物	C-藻蓝蛋白	上调MAPK/ERK信号通路,促进MITF蛋白的降解;以及下调p38 MAPK通路,抑制CREB的活化	韩国香蒲丽绿色螺旋藻海藻面膜、兰亭螺旋藻护肤品和bb霜
海洋微生物	1β,5α,6α,14-四乙酰氧基-9α-苯甲酰氧基-7βH-桉烷-2β,11-二醇、4α,5α-二乙酰氧基-9α-苯甲酰氧基-7βH-桉烷-1β,2β,11,14-四醇、thalassotalic acid A	抑制Tyr活性	韩国香蒲丽绿色螺旋藻海藻面膜、兰亭螺旋藻护肤品和bb霜

海洋来源的美白活性成分的研究进展

Research progress on whitening active ingredients from marine sources

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