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日用化学工业（中英文）

日用化学工业 ›› 2017, Vol. 47 ›› Issue (9): 497-501.doi: 10.13218/j.cnki.csdc.2017.09.004

• 开发与应用 • 上一篇    下一篇

十二烷基羟丙基磺基甜菜碱对产膜表皮葡萄球菌粘附作用的影响

段强军1, 花私齐1,2, 官妍1   

  1. 1.安徽中医药大学,安徽 合肥 230038;
    2.中国药科大学,江苏 南京 211198
  • 收稿日期:2017-06-19 发布日期:2019-03-20
  • 通讯作者: 官 妍,教授,E-mail:guanyan0726@sina.com。
  • 作者简介:段强军(1989-),安徽合肥人,助理实验师,电话:13866788015,E-mail:970813700@qq.com。
  • 基金资助:
    安徽省自然科学基金资助项目(1508085MH200);安徽省教育厅自然科学研究项目(KJ2013Z163)

Effect of dodecyl hydroxypropyl sulfobetaine on adhesion of Staphylococcus epidermidis biofilm formation bacteria

DUAN Qiang-jun1, HUA Si-qi1,2, GUAN Yan1   

  1. 1.Anhui University of Chinese Medicine,Hefei,Anhui 230038,China;
    2.China Pharmaceutical University,Nanjing,Jangsu 211198,China
  • Received:2017-06-19 Published:2019-03-20

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摘要： 通过表面活性剂十二烷基羟丙基磺基甜菜碱(DSB)对表皮葡萄球菌生物被膜菌粘附的抑制作用研究,为抗由表皮葡萄球菌生物被膜菌引起的相关感染提供新的探索方向和治疗途径。以万古霉素为阳性对照,利用XTT减低法评价DSB对表皮葡萄球菌初始粘附的影响。发现质量浓度为64 mg/L的DSB对表皮葡萄球菌初始粘附有显著的抑制作用;用质量浓度为512,256和128 mg/L的DSB对实验材料预处理后,对表皮葡萄球菌初始粘附的抑制作用明显。结果表明,DSB对表皮葡萄球菌形成生物被膜的初始粘附过程具有显著的抑制作用。

关键词: 表面活性剂, 十二烷基羟丙基磺基甜菜碱, 粘附, 表皮葡萄球菌, 生物被膜

Abstract: An investigation of inhibitory effects of surfactant dodecyl hydroxypropyl sulfobetaine (DSB) against adhesion of Staphylococcus epidermidis biofilm formation bacteria was conducted in order to find possible new research direction and treatment method of S.epidermidis biofilm bacteria associated infection.Vancomycin is applied as positive control,XTT reduction assay is used to evaluate the effect of DSB on the initial adhesion of S.epidermidis.The presented results show that DSB displays a significantly inhibitory effect on the initial adhesion of S.epidermidis at the mass concentration of 64 mg/L.After the experimental starting materials are pretreated by DSB at the mass concentration of 512,256 and 128 mg/L,the initial adhesion of S.epidermidis is significantly inhibited.Therefore,experimental results indicate that DSB has an significantly inhibitory effects on the initial adhesion in the process of biofilm formation of S.epidermidis.

Key words: surfactant, dodecyl hydroxypropylsulfobetaine, adhesion, Staphylococcus epidermidis, biofilm

中图分类号: 

  • TQ423.3