欢迎访问《日用化学工业（中英文）》，今天是
日用化学工业（中英文）

日用化学工业 ›› 2016, Vol. 46 ›› Issue (2): 92-96.doi: 10.13218/j.cnki.csdc.2016.02.007

• 开发与应用 • 上一篇    下一篇

橙皮素胶束溶液的制备及透明质酸对其稳定性和经皮渗透作用的影响

张晓宇1,侯彩平1,赵丽萍2,谢茵1,刘丽清2,何亚丽2,田青平1   

  1. 1.山西医科大学 药学院,山西 太原 030001;
    2.太原市第二人民医院 药剂科,山西 太原 030001
  • 出版日期:2016-02-22 发布日期:2016-02-22
  • 通讯作者: 田青平,教授,电话:13593178843,E-mail:tianqp123456@163.com。
  • 作者简介:张晓宇(1990-),女,硕士研究生,电话:15835132075,E-mail:403287943@qq.com。
  • 基金资助:
    山西省科技攻关项目(20140313018-8)

Preparation of hesperetin micelle pseudo solution and influence of hyaluronic acid on its stability and percutaneous osmosis action

ZHANG Xiao-yu1,HOU Cai-ping1,ZHAO Li-ping2,XIE Yin1,LIU Li-qing2,HE Ya-li2,TIAN Qing-ping1   

  1. 1.Department of Pharmacy,Shanxi Medical University,Taiyuan,Shanxi 030001,China;
    2.Pharmacy Department,Taiyuan Municipal No.2 People’s Hospital,Taiyuan,Shanxi 030001,China
  • Online:2016-02-22 Published:2016-02-22

PDF (PC)

359

赞

摘要： 制备橙皮素胶束溶液,并以Zeta电位和经皮渗透速率为指标,考察透明质酸对胶束溶液稳定性和经皮渗透活性的影响。结果表明,透明质酸可显著提高橙皮素胶束溶液的稳定性和经皮渗透活性,当其质量分数为0.5%时,胶束溶液透明稳定、无不良气味,室温下pH平均值为5.4±0.1,Zeta电位平均值为-32.62 mV,橙皮素经豚鼠皮肤的稳态渗透速率常数Js达7.475 8 μg/(cm2·h),为对照组的1.5倍。橙皮素胶束溶液耐寒和耐热实验均表现出良好的稳定性。

关键词: 护肤化妆品添加剂, 橙皮素, 胶束, 透明质酸, 稳定性, 经皮渗透活性

Abstract: Pseudo solution of hesperetin micelle was prepared,and influence of hyaluronic acid on its stability and percutaneous osmosis activity was investigated using Zeta potential and percutaneous osmosis rate as the respective indices.Experimental results showed that hyaluronic acid can significantly enhance the stability and percutaneous osmosis activity of hesperetin micelle pseudo solution.When the mass fraction of hyaluronic acid achieves 0.5%,the micelle pseudo solution becomes transparent,stable and without unpleasant odor.Under room temperature condition,its average pH value is 5.4±0.1 and average Zeta potential is -32.62 mV.The steady osmosis rate constant Js of hesperetin through cavy skin achieves 7.475 8 μg/(cm2·h),which is 1.5 multiples as compared with that of the control group.The micelle pseudo solution shows good stability in cold resistance test and heat resistance test.

Key words: skin care cosmetic additives, hesperetin, micelle, hyaluronic acid, stability, percutaneous osmosis activity

中图分类号: 

  • TQ658.2