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日用化学工业（中英文）

日用化学工业 ›› 2014, Vol. 44 ›› Issue (7): 398-401.doi: 10.13218/j.cnki.csdc.2014.07.089

• 开发与应用 • 上一篇    下一篇

包封维生素E脂质体的研究

刘本娜, 许虎君, 李芳芳, 毛建明   

  1. 江南大学 化学与材料工程学院,江苏 无锡 214122
  • 收稿日期:2014-03-06 出版日期:2014-07-22 发布日期:2019-04-08
  • 通讯作者: 许虎君,硕士生导师,E-mail:xu6205@163.com。
  • 作者简介:刘本娜(1989-),女,山东人,硕士研究生,电话:18352512715,E-mail:853847994@qq.com。

Study on liposome for encapsulating VE

LIU Ben-na, XU Hu-jun, LI Fang-fang, MAO Jian-ming   

  1. School of Chemical and Material Engineering,Jiangnan University,Wuxi,Jiangsu 214122,China
  • Received:2014-03-06 Online:2014-07-22 Published:2019-04-08

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摘要： 采用超声法制备包封维生素E的脂质体,以包封率和粒径为衡量标准,通过单因素实验确定较优的实验条件为:m(大豆卵磷脂):m(维生素E):m(胆固醇):m(聚乙烯醇)=6:3:3:2,V(氯仿):V(水)=1:3,且体系中维生素E的质量分数为8.8%,超声2 min。此条件下包封率可达86.8%,平均粒径为62.9 nm;所得脂质体呈圆球状,储存在4 ℃下较适宜。

关键词: 化妆品添加剂, 维生素E, 脂质体, 包封率, 粒径

Abstract: Preparation of liposome for encapsulating VE was conducted under assistance of ultrasonic wave.Extent of encapsulation and particle size were taken as evaluation criteria.Via single factor experiments,relatively better conditions were identified.Mass ratio of the ingredients is:m(soybean lecithin):m(VE):m(cholesterol):m(polyvinyl alcohol)=6:3:3:2.Volume ratio of solvents is:V(chloroform):V(water)=1:3.The mass fraction of VE is 8.8% in system.Ultrasonic treatment time is 2 min.Extent of encapsulation achieves 86.8% with particle size of 62.9 nm under above conditions,and the shape of the liposome product is round balls.Suitable temperature for storing the liposome product is recommended as 4 ℃.

Key words: additive of cosmetics, vitamin E, liposome, encapsulation extent, particle size

中图分类号: 

  • TQ658