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2020年, 第50卷, 第5期　刊出日期：2020-05-22 上一期    下一期

基础研究

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两亲聚合物/表面活性剂复合体系自乳化稠油研究 Study on the self-emulsified heavy oil by using amphiphilic polymer/surfactant mixtures 康鑫,康万利,朱彤宇,侯小雨,杨红斌,李梦栏,张敏 2020 (5):  287-291.  doi: 10.3969/j.issn.1001-1803.2020.05.001 摘要 ( 337 )   HTML ( 99 )   PDF(1807KB) ( 303 )   针对稠油黏度高、流动性差、开采难度大等问题,研制了一种稠油冷采自乳化复合体系。利用瓶试法、稳定性分析仪、光学显微镜和流变仪对复合体系组分进行筛选及性能评价,得到自乳化复合体系配方为0.2%月桂基葡糖苷+750 mg/L 两亲聚合物AP-C16。结果表明,在80 ℃条件下,通过翻转样品瓶月桂基葡糖苷即可将稠油完全乳化,月桂基葡糖苷与两亲聚合物AP-C16复合可增加乳状液的稳定性,稳定时间超过60 min,降黏率达到97%以上。 Aiming at the problems of heavy oil such as high viscosity, poor fluidity and difficulty in exploitation, a heavy-oil self-emulsifying composite system for cold oil recovery was developed. The bottle test method, stability analyzer, optical microscope and rheometer were used to evaluate the components of the system. The formula of the self-emulsifying composite system was 0.2% lauryl glucoside + 750 mg/L amphiphilic polymer AP-C16. The results showed that, at 80 ℃, the heavy oil could be completely emulsified with lauryl glucoside by tube turning. The mixture of lauryl glucoside and AP-C16 could increase the stability of the emulsion, in which the stabilization time exceeded 60 min, and the viscosity reduction rate reached more than 97%. 数据和表 | 参考文献 | 相关文章 | 计量指标

科技讲座

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两亲聚合物设计合成及其增效体系研究（Ⅴ）—静电作用 Study on the design and synthesis of amphiphilic polymers and their synergistic systems （Ⅴ） Electrostatic interaction 康万利,李梦栏,康鑫,蒋海壮,杨红斌,王芳 2020 (5):  292-298.  doi: 10.3969/j.issn.1001-1803.2020.05.002 摘要 ( 304 )   HTML ( 2 )   PDF(1148KB) ( 391 )   综述了近些年来基于静电相互作用所构筑的两亲聚合物超分子复配体系,主要包括带相反电荷的不同两亲聚合物复配体系、离子型两亲聚合物与有机酸复配体系、两亲聚合物与离子型表面活性剂复配体系。从复配原材料的差异出发,对所构筑的超分子体系的合成机理优势进行了总体的介绍。最后综述了静电作用在实际油田生产过程中解决问题所起到的显著效果,如静电作用在驱油、调剖以及含油废水处理等方面的应用。 The supramolecular composite systems of amphiphilic polymers based on electrostatic interactions in recent years have been reviewed, which mainly include the mixtures of different amphiphilic polymers with opposite charges, the mixtures of ionic amphiphilic polymers and organic acids, and the mixtures of amphiphilic polymers and ionic surfactants. Based on the difference of raw materials, the synthesis mechanism and advantages of the supramolecular systems are introduced. The remarkable effects of electrostatic interactions in solving problems in the actual production process of oil field are also summarized, such as applications in oil displacement, profile control and oil-bearing wastewater treatment. 数据和表 | 参考文献 | 相关文章 | 计量指标

开发与应用

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ASP驱模拟采出液动力学稳定性机理研究 Study on the mechanism of dynamic stability of simulated produced fluid in ASP flooding 单秀华,翟克平 2020 (5):  299-303.  doi: 10.3969/j.issn.1001-1803.2020.05.003 摘要 ( 216 )   HTML ( 4 )   PDF(1534KB) ( 377 )   根据油田现场提供采出液中驱油剂质量浓度变化范围,室内配制ASP驱模拟采出液,从宏观角度监测了ASP驱采出液中驱油剂类型和质量浓度变化对体系脱水率、背散射光和稳定性表征值（TSI值）的影响,同时测定了采出液的流变性和界面膜强度,从微观角度分析了模拟采出液的动力学稳定机理。结果表明,脱水率和TSI值对ASP采出液稳定性的影响规律一致。使用TURBISCAN稳定性分析仪对采出液体系进行扫描测定,得到了乳状液失稳过程的动态实时变化;随着碱质量浓度的增大,界面黏弹性先增大后减小,碱对体系黏性影响较小,界面膜强度先增强后变弱,采出液稳定性先变好后变差,当碱质量浓度为900 mg/L时采出液最稳定;随着表面活性剂质量浓度的增大界面膜弹性增大,黏性变化不大,界面膜强度增加,采出液稳定性增加;随着聚合物质量浓度的增大,油/水界面黏弹性增大、界面膜强度增加,采出液稳定性增加。 According to the variation range of the mass concentration of the oil displacement agent in the produced fluid provided in the oil field, an ASP flooding simulated produced fluid was prepared in room. The influences of the type and concentration of the oil displacement agent in ASP flooding produced fluid on the system dehydration rate, backscattered light and stability characterization value （TSI value） were monitored from a macro perspective. At the same time, the rheology and interfacial film strength of the produced fluid were measured, and the mechanism of dynamic stability of the simulated produced fluid was analyzed from a micro perspective. The results showed that the influences of dehydration rate and TSI value on the stability of ASP produced fluid were consistent. The scanning measurement of the produced fluid system by TURBISCAN stability analyzer could obtain the dynamic and real-time changes in the process of emulsion instability. With the increase of alkali mass concentration, the interface viscoelasticity first increased and then decreased, and the influence of alkali on the viscosity of the system was small. The interface film strength first increased and then weakened, and the stability of produced fluid first improved and then decreased. When the alkali mass concentration was 900 mg/L, the produced fluid was most stable. With the increase of surfactant mass concentration, the elasticity of the interfacial film increased, the viscosity changed little, the strength of the interfacial film increased, and the stability of the produced fluid increased. With the increase of polymer mass concentration, the viscoelasticity of the oil-water interface increased, the interfacial film strength increased, and the stability of the produced fluid increased. 数据和表 | 参考文献 | 相关文章 | 计量指标

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TX-100在离子液体EAN/PEG-200混合溶液中的聚集行为研究 Aggregation behavior of TX-100 in the EAN/PEG-200 mixed solution 李军,王杰,李晖,姚陈忠,谷莹秋,史利娟 2020 (5):  304-308.  doi: 10.3969/j.issn.1001-1803.2020.05.004 摘要 ( 315 )   HTML ( 4 )   PDF(1107KB) ( 336 )   通过表面张力、核磁等表征手段,研究了非离子表面活性剂TX-100在离子液体EAN纯溶剂以及EAN/聚乙二醇PEG-200混合溶液中的聚集行为。结果表明,TX-100在两种溶剂中均形成胶束;通过表征分析发现,TX-100在混合体系的表面张力和临界胶束浓度随着混合溶剂中PEG-200含量增加而增加,所形成的胶粒尺寸也增大;当混合溶剂中PEG-200含量固定时,随着温度升高,TX-100在两种体系中的cmc都增加;理论计算表明低温时是焓驱动形成胶束,高温时是熵驱动形成胶束。 The aggregation behavior of a nonionic surfactant, TX-100, in pure EAN and mixed solution of EAN/PEG-200 was investigated by surface tension measurement and NMR. The results indicated that spherical micelles were formed in both systems. With the increase of PEG-200 content in the mixed solvent, the surface tension, critical micelle concentration （cmc） and the size of the formed particles were increased. The cmc of TX-100 in the two systems increased with the increase of temperature. Theoretical calculations showed that the micellization of TX-100 in solution was enthalpy-driven at low temperature, and was entropy-driven at high temperature. 数据和表 | 参考文献 | 相关文章 | 计量指标

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氨基酸型复合纳米乳抑菌性能的研究 Bacteriostatic properties of amino acid composite nanoemulsion 赵志娟,公培龙,崔晓东,王转花 2020 (5):  309-313.  doi: 10.3969/j.issn.1001-1803.2020.05.005 摘要 ( 318 )   HTML ( 16 )   PDF(899KB) ( 366 )   以氨基酸型表面活性剂月桂酰肌氨酸钠与PEG-40氢化蓖麻油为复合乳化剂,1,2-丙二醇为助乳化剂,蓖麻油为油相,构建荞麦黄酮纳米乳体系,并对其抑菌活性进行评价。结果表明,纳米乳外观透明澄清,粒径分布均匀,其均匀分散指数（PDI）、表面张力、pH值等均表明形成的纳米乳体系良好。体外释放性能显示24 h内,纳米乳累积释放量明显优于对照混悬液。纳米乳及混悬液对金黄色葡萄球菌和大肠杆菌的最小抑菌浓度（MIC）和最小杀菌浓度（MBC）测定结果表明,纳米乳的抑菌活性明显高于混悬液。悬液定量法测定纳米乳对金黄色葡萄球菌、大肠杆菌的抑菌率分别为92.1%±1.93%和93.2%±1.26%;同浓度混悬液对金黄色葡萄球菌、大肠杆菌的抑菌率分别为42.0%±1.58%和45.6%±2.33%。 The buckwheat flavone nanoemulsion system was constructed with amino acid surfactant sodium lauroyl sarcosinate and PEG-40 hydrogenated castor oil as the composit emulsifiers, 1,2-propylene glycol as co-emulsifier and castor oil as oil phase, and its bacteriostatic activity was evaluated. The results showed that the nanoemulsion was transparent and clear in appearance, with uniform particle size distribution. The PDI, surface tension and pH value all showed that the nanoemulsion system was good. In vitro release performance showed that the cumulative release of nanoemulsion was significantly better than that of control suspension within 24 h. The minimum inhibitory concentration （MIC） and the minimum bactericidal concentration （MBC） of nanoemulsion and suspension to Staphylococcus aureus and Escherichia coli showed that the bacteriostatic activity of nanoemulsion was significantly higher than that of suspension. The bacteriostatic rates of nanoemulsion against Staphylococcus aureus and Escherichia coli were 92.1%±1.93% and 93.2%±1.26%, respectively, and those of the suspension of the same concentration against Staphylococcus aureus and Escherichia coli were 42.0%±1.58% and 45.6%±2.33%, respectively. 数据和表 | 参考文献 | 相关文章 | 计量指标

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含吡啶杂环氯化铵阳离子表面活性剂的杀菌活性 Bactericidal activity of pyridine-containing heterocyclic ammonium chloride cationic surfactants 李云晴,王丽艳,唐丽,刘家庆,杜昱瀛,吴定成 2020 (5):  314-318.  doi: 10.3969/j.issn.1001-1803.2020.05.006 摘要 ( 321 )   HTML ( 9 )   PDF(1005KB) ( 487 )   旨在筛选具有较好的水溶性、绿色环保、对植物病原菌具有较强杀菌性的杀菌剂。利用琼脂平板稀释法测定不同碳链长度的含吡啶杂环氯化铵（简称C8,C10,C12,C14,C16）阳离子表面活性剂对四种植物病原菌的离体杀菌活性,求出毒力回归方程,并计算有效抑菌浓度EC50值。结果表明：碳链长度为12的含吡啶杂环氯化铵（C12）阳离子表面活性剂对水稻纹枯病原菌的EC50=9.69×10 -3 g/L、对照药井岗霉素的EC50=7.02×10 -2 g/L;对西瓜枯萎病原菌的EC50=2.93×10 -2 g/L、对照药甲基布拖津的EC50=0.506 g/L;对苹果腐烂病原菌的EC50=1.57×10 -5 g/L、对照药苯醚甲环唑的EC50=3.50×10 -4 g/L;对番茄灰霉病原菌的EC50=1.85×10 -4 g/L、对照药菌恶唑的EC50=2.04×10 -3 g/L。即C12对四种病原菌的EC50值明显低于对照药剂,具有较好的杀菌活性,具有进一步研究的价值。通过相同试验方法进一步得到C12对四种病原菌的最小抑菌浓度（MIC）分别为0.094,0.091,0.083和0.087 g/L。为含吡啶杂环氯化铵阳离子表面活性剂对植物病原菌的防治研究提供依据。 The purpose is to screen fungicides with good water solubility, environmental protection and strong bactericidal effect on plant pathogens. The bactericidal activity of pyridine-containing heterocyclic ammonium chloride cationic surfactants with different carbon chain lengths （C8, C10, C12, C14, C16） against four kinds of plant pathogens was tested by agar plate dilution method. The toxicity regression equation was obtained, and the effective antibacterial concentration （EC50） was calculated. The results show that the pyridine-containing heterocyclic ammonium chloride cationic surfactants with a carbon chain length of 12 （C12） has a significant antibacterial activity for Rhizoctonia solani Kühn, watermelon Fusarium wilt, apple valsa canker and Botrytis cinerea Pers. with the EC50 of 9.69×10 -3, 2.93×10 -2, 1.57×10 -5 and 1.85×10 -4g/L, respectively. While the EC50 of the control drugs containing jinggangmycin, methyl butazine, difenoconazole and mycoazole for the above plant pathogens individually are 7.02×10 -2, 0.506, 3.50×10 -4 and 2.04×10 -3 g/L, respectively. The EC50 value of C12 for four pathogens are significantly lower than the control drugs, which has good bactericidal activity and further research value. The minimal inhibitory concentration （MIC） of C12 against the four plant pathogens are 0.094, 0.091, 0.083 and 0.087 g/L, respectively. It provides the basis for the research on the prevention and treatment of plant pathogens by pyridine-containing heterocyclic ammonium chloride cationic surfactants. 数据和表 | 参考文献 | 相关文章 | 计量指标

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聚甘油脂肪酸酯W/O/W多重乳液的稳定性研究 Study on the stability of polyglycerol fatty acid ester W/O/W multiple emulsion 呼酩杰,许虎君 2020 (5):  319-324.  doi: 10.3969/j.issn.1001-1803.2020.05.007 摘要 ( 508 )   HTML ( 22 )   PDF(1498KB) ( 661 )   以聚甘油-2-二油酸酯、十聚甘油单月桂酸酯分别替代Span-80、Tween-80作为W/O、O/W乳化剂,以液体石蜡作为油相制备W/O/W多重乳液;以乳液的分层率作为乳液稳定程度的标准,探讨了乳化剂种类、乳化剂质量分数及油水体积比对W/O/W多重乳状液体系稳定性的影响。借用旋转流变仪对乳液流变性能进行测定,探讨脂肪醇（CmH2m+1OH,m=12,14,16,18和20）、高聚物（黄原胶、羟乙基纤维素、小核菌胶）对W/O/W多重乳液流变性质的影响。结果表明稳定的W/O/W多重乳液较优组成,初级乳液（W/O）：聚甘油-2-二油酸酯质量分数为10%,V（液体石蜡）∶V（水）= 2∶1;W/O/W多重乳液：十聚甘油单月桂酸酯质量分数为6%,V（初级乳液）∶V（水）=9∶10,脂肪醇（十六醇）质量分数为2%,高聚物（黄原胶）质量分数为0.15%。 The W/O/W multiple emulsion was prepared by using polyglycerol-2-dioleate and decaglycerin monolaurate instead of Span-80 and Tween-80 as W/O and O/W emulsifiers, respectively, and using liquid paraffin as the oil phase. The delamination rate of the emulsion was used as the standard for the stability of the emulsion. The effects of emulsifier type, emulsifier mass fraction and oil-water ratio on the stability of W/O/W multiple emulsion system were discussed. The rheological properties of the emulsion were measured by a rotary rheometer. The effects of fatty alcohols （CmH2m+1OH, m=12, 14, 16, 18, 20） and polymers （xanthan gum, hydroxyethyl cellulose, nucleocapsid） on the rheological properties of W/O/W multiple emulsions were investigated. The results show that the suitable W/O/W multiple emulsions has a superior composition. The primary emulsion （W/O）: polyglycerol-2-dioleate has a mass fraction of 10%, and V（liquid paraffin）∶V（water）= 2∶1; W/O/W multiple emulsion: octaglycerol monolaurate mass fraction is 6%, V（primary emulsion）∶ V（water）=9∶10, fatty alcohol （cetyl alcohol） mass fraction is 2%, the high polymer （xanthan gum） mass fraction is 0.15%. 数据和表 | 参考文献 | 相关文章 | 计量指标

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6种乳酸菌发酵液对皮肤抗氧化及美白功能的评价 Evaluation of six lactobacillus fermentation broth on skin antioxidant and whitening function 邓逸琳,王斌,曹辉 2020 (5):  325-330.  doi: 10.3969/j.issn.1001-1803.2020.05.008 摘要 ( 724 )   HTML ( 14 )   PDF(1357KB) ( 886 )   考察并比较了6种乳酸菌发酵上清液中多肽和胞外多糖含量,发现Lactobacillus plantarum N2发酵上清液中多肽含量最高可达1.7 g/L,Lactobacillus plantarum N4发酵上清液中胞外多糖含量最高可达5.0 g/L。通过ABTS+自由基清除能力、ROS自由基清除能力和对SOD酶活性、CAT酶活性的影响来评价乳酸菌抗氧化能力,通过对酪氨酸酶的抑制率和对细胞内黑色素含量的影响来评价种乳酸菌的美白能力。实验结果表明,乳酸菌发酵上清液具有一定的抗氧化能力和美白能力,其中N2和N4的自由基清除活性皆高于Vc组,N2和N4对酪氨酸酶的抑制率分别可达到71%和68%。N2和N4具有较好的抗氧化和美白能力。 The content of polypeptide and exopolysaccharide in the fermentation supernatant of six kinds of lactic acid bacteria was investigated and compared. It was found that the content of polypeptide in the supernatant of Lactobacillus plantarum N2 was up to 1.7 g/L, and the content of exopolysaccharide in the supernatant of Lactobacillus plantarum N4 was up to 5.0 g/L. The antioxidant capacity of six kinds of lactic acid bacteria was evaluated by ABTS+ free radical scavenging capacity, ROS free radical scavenging capacity and the influence on SOD enzyme activity and CAT enzyme activity. Then, the whitening ability of six kinds of Lactobacillus was evaluated by the inhibition rate of tyrosinase and the effect on the content of melanin in cells. The results show that FMS has certain antioxidant and whitening ability, in which the free radical scavenging activities of N2 and N4 were higher than those of Vc group. The inhibition rates of N2 and N4 to tyrosinase were 71% and 68%, respectively. N2 and N4 have good antioxidant and whitening ability. 数据和表 | 参考文献 | 相关文章 | 计量指标

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复合多肽眼霜的延缓衰老功效测试与分析 Test and analysis of anti-aging effect of the eye creamcontaining polypeptides 欧春凤,许晓华,万阳,徐晶,夏晓初,马义 2020 (5):  331-335.  doi: 10.3969/j.issn.1001-1803.2020.05.009 摘要 ( 605 )   HTML ( 22 )   PDF(1174KB) ( 708 )   对实验室自制的复合多肽眼霜进行临床功效测试,评价其抗衰效果。选取30名有效受试者为研究对象,选用无创仪器检测方法,监测对照组和测试组使用对应产品0,2,4和8周的皮肤角质层水分含量、弹性、粗糙度、皱纹体积和皱纹面积占比,以及受试者主观评价结果,并借助SPSS数据统计软件对实验结果进行统计分析。结果显示,复合多肽眼霜对皮肤角质层水分含量的提高、皮肤弹性的增强、眼部皱纹的减少具有显著作用,说明其具有良好的抗衰老功效。 The clinical efficacy of self-made eye cream containing polypeptides was tested to evaluate its anti-aging effect. Thirty valid subjects were selected as the research objects, and non-invasive instrument was used to detect and record the water content, elasticity, roughness, wrinkle area/AOI area in the test group and the control group at 0, 2, 4 and 8 weeks using corresponding products, and the subjective evaluation results of the subjects were also recorded with SPSS data. The software was used to make statistics on the experimental results. The results showed that the use of polypeptide composite in eye cream has significant effects in improving the water content in cuticle, the skin elasticity and the reduction of wrinkles. That is to say, composite-polypeptide eye cream has good anti-aging effect. 数据和表 | 参考文献 | 相关文章 | 计量指标

专论与综述

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痤疮的机理症状及祛痘型护肤品功效类型 The mechanism and symptoms of acne and the functions and types of acne skin care products 何陵玲,张毅,龚秋君,张青 2020 (5):  336-342.  doi: 10.3969/j.issn.1001-1803.2020.05.010 摘要 ( 867 )   HTML ( 57 )   PDF(815KB) ( 3583 )   痤疮是一种容易发生在青少年的炎症性皮肤病,有多个因素可导致痤疮的发生,包括内分泌失调,角质化异常等。介绍了痤疮的发生机理;阐述了痤疮的症状,包括根据中国痤疮治疗指南分类的各级症状和瘢痕;基于痤疮发生机理对祛痘型护肤品作用功效进行详细介绍,并简单介绍几款祛痘型护肤品类型,对症下药地选择不同功效的祛痘型护肤品。最后对痤疮型护肤品的正确使用及痤疮机理的完善进行了展望。 Acne is a kind of inflammatory skin disease which easily occurs on adolescent. Many factors can cause acne, including endocrine dyscrasia, abnormal keratinization and so on. The mechanism and symptoms of acne have been introduced, in which the symptoms include different clinical features, according to China acne treatment guide, and scar. The efficacy of anti-acne skin care products are introduced in detail based on the mechanism. Several types of skin care products are briefly introduced. It is necessary to choose proper functional products to cope with different symptoms. Finally, we are looking forward to the correct usage of products and the complement of acne mechanism. 参考文献 | 相关文章 | 计量指标

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化妆品中准用着色剂的检测方法和使用情况研究 Research on the detection and application of allowed colorants in cosmetics 顾宇翔,薛峰,郑翌 2020 (5):  343-348.  doi: 10.3969/j.issn.1001-1803.2020.05.011 摘要 ( 464 )   HTML ( 13 )   PDF(787KB) ( 543 )   概述了化妆品中着色剂的种类、安全风险和《化妆品安全技术规范》（2015年版）对准用着色剂的规定,介绍目前检测标准和文献方法所涵盖的准用着色剂范围,综述了液相色谱、液相色谱-质谱等方法在着色剂测定上的应用情况及其优劣,并对近年来市场上化妆品中准用着色剂的使用情况进行了分析,最后提出了着色剂检测技术的发展趋势。 The categories and safety risks of colorants in cosmetics, and the allowed colorants in “Cosmetics Safety Technical Specifications” （2015 Edition） were presented. The detection standards and cutting-edge methods referring the colorants that were legally used in cosmetics were introduced. The advantages and disadvantages of HPLC and HPLC-MS methods were introduced. The use of colorants allowed in cosmetics on the market in recent years was analyzed. Finally, the future trend of detection methods was proposed. 数据和表 | 参考文献 | 相关文章 | 计量指标

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我国合成脂肪酸生产技术发展的历史考察 Historical investigation on the development of production technology for synthetic fatty acids in China 王鹏飞 2020 (5):  349-353.  doi: 10.3969/j.issn.1001-1803.2020.05.012 摘要 ( 282 )   HTML ( 8 )   PDF(788KB) ( 461 )   合成脂肪酸生产技术是我国现代洗涤工业技术乃至化学工业技术发展历程中的重要组成部分。综述了合成脂肪酸生产技术在我国的发展历程,分析了不同历史时期技术的发展形态以及其与社会需求、政府政策之间的互动关系,同时提出合成脂肪酸生产技术的历史贡献以及对其发展的思考。 The production technology for synthetic fatty acids is a significant part of technology in cleaning industry and chemical industry in contemporary China. This article has focused on the developing process of the production technology for synthetic fatty acids in China, and the relationship among technology, social demand and government policy in different historical periods. Finally, the historical contribution of the production technology for synthetic fatty acids has been pointed out, as well as the thinking about its development. 参考文献 | 相关文章 | 计量指标

分析与检测

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高效液相色谱-串联质谱法同时测定养发类化妆品中15种违禁药物 Simultaneous determination of 15 prohibited drugs in hair nourishing cosmetics by HPLC-MS/MS 刘红,李晓健,胡贝,李丽霞,丁晓萍 2020 (5):  354-358.  doi: 10.3969/j.issn.1001-1803.2020.05.013 摘要 ( 395 )   HTML ( 10 )   PDF(848KB) ( 433 )   建立了高效液相色谱-串联质谱法（HPLC-MS/MS）同时测定养发类化妆品中15种违禁药物的分析方法。样品采用甲醇超声提取,经C18色谱柱分离,采用多反应监测（MRM）扫描方式测定。15种违禁药物的检出限（LODs）为1~20 μg/kg,在10~200 μg/L范围内线性关系良好,相关系数均大于0.998。回收率为84.2%~114.6%,相对标准偏差（RSD,n=6）为1.7%~9.7%。该方法简单、灵敏、准确,可作为养发类化妆品中15种违禁药物的筛查方法。 Liquid chromatography-tandem mass spectrometric （HPLC-MS/MS） method was established for the simultaneous determination of 15 prohibited drugs in hair cosmetics. Samples were extracted by methanol ultrasonic, separated by a C18 column, and determined by multiple reaction monitoring （MRM） scanning mode. The limits of detection （LODs） of the 15 prohibited drugs in various kinds of cosmetics are in the range of 1-20 μg/kg, with a linear relationship in the range of 10-200 μg/L, and the correlation coefficients are all greater than 0.998. The average recoveries are in the range of 84.2%-114.6%, and the relative standard deviation （RSD, n=6） is in the range of 1.7% to 9.7%. The method is simple, sensitive and accurate, and is suitable for the quick screening of 15 prohibited drugs in hair cosmetics. 数据和表 | 参考文献 | 相关文章 | 计量指标