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2026年, 第56卷, 第4期　刊出日期：2026-04-22 上一期    下一期

特邀专稿

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同步辐射小角散射技术在化妆品纳米结构表征中的应用与挑战 Applications and challenges of synchrotron small-angle scattering in nanostructure characterization of cosmetics 虞杰, 邹爱华, 李娜 2026 (4):  407-424.  doi: 10.3969/j.issn.2097-2806.2026.04.001 摘要 ( 119 )   HTML ( 20 )   PDF(13738KB) ( 91 )   化妆品类别丰富，涵盖防晒、洗护及彩妆等多个品类。这些产品普遍属于组分复杂、相互作用精细的多相软物质体系，其内部通常包含分布在1~100 nm空间尺度的层状液晶、囊泡、胶束、微乳、纳米颗粒及其构成的动态组装网络，这些纳米结构对产品的稳定性、肤感、递送行为及功效表现具有决定性影响。小角X射线散射（SAXS）技术可以在不破坏产品，且接近真实配方与使用状态的条件下，实现对体系纳米结构的原位、系综平均结构表征（Ensemble-averaged），该技术已成为贯穿化妆品产品配方设计、工艺优化与放大、质量控制、一致性评价及结构-功效关联研究的重要结构表征手段。该综述回顾了近年来学术界与产业界在化妆品纳米结构SAXS表征方面的研究进展，梳理了SAXS技术在典型配方体系中的应用方向与代表性案例，进一步讨论了当前在复杂多组分体系解析、数据建模与结果可解释性方面遇到的机遇与挑战，同时思考了上海同步辐射光源（SSRF）生物小角X射线散射实验装置BL19U2赋能化妆品研究的可能性。最后结合人工智能（Artificial intelligence，AI）驱动的数据分析与多模态结构表征发展趋势，展望SAXS技术在化妆品配方理性设计与功效机制研究中的未来应用前景。 Cosmetic products encompass a broad range of categories, including sunscreens, personal care products, and color cosmetics. These products are typically multiphase soft matter systems composed of multiple components with complicated interactions. Their interior commonly contains entities with spatial scale from 1 to 100 nm, including lamellar liquid crystals, vesicles, micelles, microemulsions, nanoparticles, and weakly interacting networks formed by these entities. Such nanostructures play a decisive role in stability, sensory properties, delivery behavior, and overall efficacy of cosmetic products. Small-angle X-ray scattering （SAXS） enables in-situ and ensemble-averaged structural characterization of nanoscale structures under non-destructive conditions in real formulations and actual application states. Therefore, SAXS has now become an essential structural characterization tool throughout cosmetic formulation design, process optimization and scale-up, quality control, consistency evaluation, and structure-function relationship research. In this review, both recent academic and industrial progresses of SAXS for characterizing cosmetic nanostructures were summarized. Representative applications and case studies of SAXS in typical cosmetic systems were systematically discussed. Furthermore, current opportunities and challenges in the aspects of data interpretation in complex multi-component systems, including modeling strategies and result interpretability, were critically analyzed. The potential of BioSAXS beamline BL19U2 at the Shanghai Synchrotron Radiation Facility （SSRF） to empower cosmetic research was also discussed. Finally, considering the emerging trends in artificial intelligence-driven data analysis and multimodal structural characterization, the prospects for SAXS applications in the rational design of cosmetic formulations and the mechanism studies of efficacy were discussed. 数据和表 | 参考文献 | 相关文章 | 计量指标

科技讲座

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黏弹性表面活性剂（IV）——动态流变 Viscoelastic surfactants (IV) Dynamic rheology 冯玉军 2026 (4):  425-432.  doi: 10.3969/j.issn.2097-2806.2026.04.002 摘要 ( 82 )   HTML ( 4 )   PDF(4594KB) ( 78 )   蠕虫状胶束的动态流变行为是连接微观结构与宏观性能的关键，是黏弹性的最直观反映。本文系统综述了蠕虫状胶束的动态流变特性，重点阐述了线性与非线性动态流变行为规律：线性动态流变以小振幅振荡剪切（SAOS）为核心，黏弹性响应多符合Maxwell模型，可通过宽频测试提取介观结构参数；非线性动态流变（含大振幅振荡剪切（LAOS））中，Wisenberg数Wi>1时会出现剪切带、应变硬化等典型现象，切比雪夫分解法（TDM）与物理过程序列法（SPPM）为主要解析手段。总结了动态流变在油气开采、个人护理、生物医药等领域的应用指导价值，指出介观参数测试依赖模型拟合、非线性普适本构模型缺失等核心难题。最后展望多尺度耦合、原位表征、理论创新与应用导向的未来研究方向，为相关领域精准调控流变性与规模化应用提供参考。 Wormlike micelles （WLMs） feature dynamic rheological behaviors that connect their microstructural dynamics to macroscale performance, underpinning diverse industrial applications. In this review, WLM dynamic rheology was introduced, and the rules in linear and nonlinear dynamic rheological behaviors were elucidated. Unlike steady-state rheology, dynamic rheology is characterized by viscoelastic responses, relaxation kinetics, and structural changes in alternating flow fields, targeting quantitative relationships between rheological parameters, microstructures, and flow conditions. Linear dynamic rheology has been measured by the test of small amplitude oscillatory shear （SAOS）, whose viscoelastic responses mostly conform to Maxwell model. The key parameters and mesoscopic structural data are extracted by broadband techniques. Nonlinear behaviors （the Wisenberg number Wi > 1） include shear banding, strain hardening, and elastic instabilities, which are characterized by large amplitude oscillatory shear （LAOS） with TDM and SPPM. The understanding of dynamic rheology is valuable to guide the applications of WLMs in oil and gas industry （tunable fracturing fluids）, personal care （biodegradable thickeners）, biomedicine （stimuli-responsive drug delivery）, and smart materials. Core challenges involve model-dependent mesoscopic parameter extraction and lack of universal nonlinear models. Future research should prioritize multi-scale coupling, in-situ characterization, theoretical innovation, and industry-adapted designs to advance WLM commercialization. 数据和表 | 参考文献 | 相关文章 | 计量指标

基础研究

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直链脂肪醇聚氧乙烯醚稳定的高含氢硅油乳液的制备及其性能研究 Preparation and performance of high-hydrogen silicone oil emulsions stabilized with straight-chain fatty alcohol polyoxyethylene ethers 王晓, 梁晓丫, 韩志旺, 杨佳茜, 智丽飞, 李志云, 王国永 2026 (4):  433-440.  doi: 10.3969/j.issn.2097-2806.2026.04.003 摘要 ( 107 )   HTML ( 7 )   PDF(4500KB) ( 79 )   采用机械乳化法制备了以高含氢硅油（H=1.6%）为分散相、水为分散介质的乳液体系，其中选用脂肪醇聚氧乙烯醚AEO-3和AEO-9作为复合乳化剂。重点考察了乳化剂复配质量比和用量对乳液稳定性的影响规律，并基于乳化剂的表面性能、乳液粒径分布及微观形貌分析，深入探究了乳液的稳定机理。结果表明，高含氢硅油乳液较佳制备条件为：高含氢硅油的含量为35%，AEO-3和AEO-9的质量比为7∶3，乳化剂用量为高含氢硅油乳液质量的2%，乳化搅拌速率为3 000 r/min。此条件下制得的高含氢硅油乳液外观为乳白色液体，离心稳定性和稀释稳定性良好，乳液粒径为1.30 μm左右，且90天后粒径尺寸变化不大。高含氢硅油乳液对载玻片表面的改性测试表明，水在经高含氢硅油乳液处理后的载玻片表面的接触角最高可达123.3°，50次冲洗后接触角仍保持114.5°，表明乳液具有良好的防水性能。该研究为高含氢硅油乳液的应用提供了坚实理论依据和技术支持。 High-hydrogen silicone oil-in-water emulsions were prepared by mechanical emulsification using polymethylhydrosiloxane trimethylsiloxy terminated （H=1.6%） as the dispersed phase and fatty alcohol polyoxyethylene ethers AEO-3 and AEO-9 as the mixed emulsifiers. The effects of the mass ratio and dosage of the mixed emulsifiers on the stability of emulsions were investigated. The stabilization mechanism of the emulsion was studied by analyzing the surface/interfacial activities of the mixed emulsifiers and the particle size distribution and microstructure of the emulsion. The results showed that the optimized conditions for preparation of the emulsion were as follows: The content of polymethylhydrosiloxane trimethylsiloxy terminated was 35%, the mass ratio of AEO-3∶AEO-9 was 7∶3, the total dosage of the mixed emulsifiers was 2% of the mass of the emulsion, and the stirring rate for emulsification was 3 000 r/min. The appearance of the emulsion thus prepared was a milky white liquid, indicative of good centrifugal stability and dilution stability, and the particle size of the emulsion was approximately 1.30 μm and merely increased to 1.76 μm after 90 days. The results for modification of the surface of a microscope slide with the high-hydrogen silicone oil emulsion showed that, the contact angle of water on the surface of the slide treated with the emulsion could reach 123.3 °, and the contact angle was still 114.5 ° after 50 times of rinsing, which indicated that the emulsion endowed the slide with good water repellency. This work could provide theoretical basis and technical support for application of high-hydrogen silicone oil emulsions. 数据和表 | 参考文献 | 相关文章 | 计量指标

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非离子表面活性剂在SiO2气凝胶分散过程中的改性机理与性能研究 Study on the modification mechanism and performance of nonionic surfactants in the dispersion process of SiO2 aerogels 万郁楠, 任真, 张一纯 2026 (4):  441-448.  doi: 10.3969/j.issn.2097-2806.2026.04.004 摘要 ( 93 )   HTML ( 7 )   PDF(94340KB) ( 113 )   分别用非离子表面活性剂脂肪酸甲酯乙氧基化物（FMEE）、脂肪醇聚氧乙烯醚（AEO9）、烷基多糖苷（APG08-10）和壬基酚聚氧乙烯醚（NP-10）对SiO2气凝胶（AG）进行表面改性，制备得到4种表面活性剂-AG分散体系。利用沉降体积比、平均粒径、Zeta电位、FT-IR和TEM等对其分散性进行了评价，分析了不同表面活性剂在AG表面的吸附方式以及对分散性能的作用机理和影响规律。结果表明：FMEE、AEO9、APG08-10、NP-10的质量分数分别为0.04%、0.10%、0.04%、0.06%时体系分散效果优于其他样品，分散性能顺序为：NP-10>AEO9>FMEE>APG08-10，其中，NP-10在疏水作用和范德华力作用下与AG颗粒相互吸引，苯环则通过π-π堆积作用垂直吸附至AG颗粒表面上，长聚氧乙烯醚（EO）链在液相中良好的空间位阻作用克服了AG颗粒之间的吸附团聚，保证了分散体系的稳定性。 Four dispersion systems were prepared by surface modification of SiO2 aerogel （AG） with four different nonionic surfactants, including fatty acid methyl ester ethoxylate （FMEE）, fatty alcohol polyoxyethylene ether （AEO9）, alkyl polyglycoside （APG08-10）, and nonylphenol polyoxyethylene ether （NP-10）. The dispersity was evaluated by sedimentation volume ratio, Zeta potential, average particle size, FT-IR and TEM. The adsorption modes for different surfactants on the surface of AG and their effects on dispersing performance were analyzed. The results showed that the best dispersion of AG system was achieved at mass fractions of FMEE, AEO9, APG08-10 and NP-10 of 0.04%, 0.10%, 0.04% and 0.06%, respectively. The order of dispersity of surfactant-modified AG was NP-10 > AEO9 > FMEE > APG08-10. NP-10 attracted AG particles through hydrophobic interaction and van der Waals force, with its benzene ring adsorbing vertically onto the AG particle surface via π-π stacking. The strong steric hindrance of the long polyoxyethylene （EO） chain in the liquid phase prevented adsorptive agglomeration among AG particles and thus ensured the stability of the dispersion. 数据和表 | 参考文献 | 相关文章 | 计量指标

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用于改善透明质酸透皮性能的阳离子脂质体递送系统的构建与评价 Construction of a cationic liposomal system for enhanced transdermal delivery of hyaluronic acid 王宇, 任爽, 杨素珍, 韩婷婷, 姬迎迎, 张子嘉, 张婉萍 2026 (4):  449-462.  doi: 10.3969/j.issn.2097-2806.2026.04.005 摘要 ( 89 )   HTML ( 6 )   PDF(5210KB) ( 75 )   针对大分子透明质酸（HA）经皮渗透效率低的问题开发了一种基于十八烷基三甲基氯化铵（OTAC）的阳离子脂质体（OTAC-L）递送系统，该系统通过静电作用实现了对HA的高效包载（包封率为89%），并显著增强了其经皮渗透能力。首先通过粒径、Zeta电位、包封率的测定、荧光探针对膜性质的分析以及鸡胚实验进行OTAC加入量的优化，成功制备出粒径为（90.42±1.92） nm，多分散指数为0.23±0.02的阳离子透明质酸脂质体（OTAC-HA-L）。透射电子显微镜观察证实脂质体为形态规整的球形结构，低场核磁共振与等温量热滴定分别通过研究脂质体水分子运动状态的变化和与HA结合过程的热力学参数，验证了HA与阳离子脂质体之间的高效结合。傅里叶变换红外光谱分析揭示了HA的特征吸收峰变化，证实其被成功包载，并与脂质体间存在静电相互作用。体外渗透实验表明，OTAC-HA-L的透皮性能显著提升，12 h累积透过率达到15.3%，分别为普通脂质体和HA水溶液的1.91倍和2.56倍。且其在常温、高温和低温条件下均表现出良好稳定性，为HA在皮肤护理领域的深层递送提供了一种具有重要应用前景的解决方案。 In this study, we developed a cationic liposome （OTAC-L） delivery system based on octadecyltrimethylammonium chloride （OTAC） to enhance the low percutaneous permeability of hyaluronic acid. OTAC-HA-L was successfully prepared, showing a particle size of （90.42±1.92）nm and a polydispersity index of 0.23±0.02. This was achieved through measurements of particle size, Zeta potential, and entrapment efficiency, as well as analysis film properties using a fluorescence probe and optimizing the OTAC amount in chicken embryo experiments. Transmission electron microscopy （TEM） confirmed that the liposomes had a regular spherical shape. Low-field NMR and isothermal calorimetry were employed to investigate the molecular movement of water and the thermodynamic parameters of the HA binding process, respectively, confirming the effective binding between HA and cationic liposomes. Fourier transform infrared spectroscopy （FT-IR） identified the characteristic absorption peak of HA, confirming successful loading of HA and interaction with the liposomes. In vitro permeation tests showed that OTAC-HA-L’s permeation performance was significantly improved, with a cumulative permeation rate of 15% at 12 hours, which was 1.91 and 2.56 times higher than that of standard liposomes and aqueous HA, respectively. Additionally, the system demonstrated good stability under normal-, high-, and low-temperature conditions, making it a promising approach for deep HA delivery in skin care. 数据和表 | 参考文献 | 相关文章 | 计量指标

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咖啡渣多酚提取及抗氧化性能研究 Extraction of polyphenols from spent coffee grounds and their antioxidant activity 刘佳琳, 李萌, 宁霄, 曹进 2026 (4):  463-470.  doi: 10.3969/j.issn.2097-2806.2026.04.006 摘要 ( 111 )   HTML ( 9 )   PDF(4772KB) ( 104 )   采用超声辅助提取结合响应面分析法对咖啡渣中多酚类物质的提取工艺进行优化研究，以提取温度、提取时间和液料比为主要变量，考察其对多酚得率的影响，获得该实验最佳工艺条件为：温度49 ℃，时间25 min，液料比29∶1 （mL/g），此条件下总多酚提取量为16.71 mg GAE/g DW。与模型预测值（16.75 mg GAE/g DW）高度吻合，验证了模型的准确性。通过DPPH和PTIO自由基清除实验比较超声提取液与水提液的抗氧化活性，结果表明，超声提取液在体积分数为4%下DPPH清除率为99.38%，高于水提液；在PTIO自由基清除实验中，超声提取液在体积分数为80%时清除率为27.86%，而水提液在体积分数为100%时清除率为36.19%，两者在不同自由基体系中表现存在差异。通过超高效液相色谱-质谱联用技术（UHPLC-MS）鉴定出绿原酸、鞣花酸和原儿茶酸等主要多酚类物质，阐明了其抗氧化活性的物质基础。研究结果表明，用超声辅助技术能够显著提高咖啡渣中多酚的提取效率，所得提取物具有良好的抗氧化能力，并显示出在护肤品中的潜在应用价值，为咖啡渣的高值化利用提供了技术参考和科学依据。 Ultrasound-assisted extraction （UAE） coupled with response surface methodology （RSM） was applied to optimize the recovery of polyphenols from spent coffee grounds （SCGs）, a typical by-product of the coffee industry. Extraction temperature, time, and liquid-to-solid ratio were investigated as major variables. The optimal conditions are determined to be 49 ℃, 25 min, and a liquid-to-solid ratio of 29∶1 （mL/g）. Under these conditions, the total polyphenol yield reaches 16.71 mg GAE/g DW, which closely matches the predicted value of 16.75 mg GAE/g DW, thereby verifying the accuracy of the model. Antioxidant activity was evaluated by DPPH and PTIO radical scavenging assays. At a volume fraction of 4%, the UAE extract shows a DPPH scavenging rate of 99.38%, which is higher than that of the water extract. In the PTIO assay, the UAE extract shows a scavenging rate of 27.86% at a volume fraction of 80%, whereas the water extract reaches 36.19% at 100%. Moreover, ultra-high-performance liquid chromatography-mass spectrometry （UHPLC-MS） identifies chlorogenic acid, ellagic acid, and protocatechuic acid as the major phenolic compounds, confirming the chemical basis of the antioxidant effect. These findings demonstrate that UAE not only enhances the extraction efficiency of polyphenols from SCGs but also yields extracts with strong antioxidant activity. The study provides technical support and scientific evidence for the valorization of coffee by-products as natural antioxidants, highlighting their potential application in skincare formulations and daily chemical products. 数据和表 | 参考文献 | 相关文章 | 计量指标

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黑色素生成抑制肽的设计筛选及功效评价研究 Design, screening and efficacy evaluation of melanin-production inhibitory peptides 董雨, 荣绍丰, 管世敏, 李茜茜 2026 (4):  471-478.  doi: 10.3969/j.issn.2097-2806.2026.04.007 摘要 ( 83 )   HTML ( 3 )   PDF(5647KB) ( 82 )   针对目前具有黑色素抑制活性四肽的相关研究较少，文章以黑色素抑制活性为研究目标，通过构建虚拟肽库、建立设计筛选方法，对具有黑色素抑制活性的四肽进行筛选及功效评价。文章以虚拟肽库为基础，借助分子对接、活性预测、作用力分析等技术手段，对目标活性四肽进行筛选，再利用固相肽合成法对目标四肽进行定向合成，进一步从生化检测、细胞模型、分子转录等角度，对目标活性四肽进行功效评价。经筛选获得4条四肽：肽-1 （CHWH）、肽-2 （RVGW）、肽-3 （LHSY） 和肽-4 （LFSY）。相比其他三条四肽，肽-1表现出更好的Cu2+螯合、ABTS阳离子自由基清除和酪氨酸酶抑制活性。同时，其在B16细胞模型内的酪氨酸酶活性和黑色素生成抑制的IC50分别为0.28和0.20 g/L，且在10 g/L质量浓度以下对细胞增殖率无显著影响。转录水平研究也进一步显示，肽-1能够降低细胞内MITF（小眼畸形转录因子）和TYR（酪氨酸酶）基因表达水平，且呈浓度依赖性。 Currently, there is little research on tetrapeptides with melanin inhibitory activity. This article aims to study melanin inhibition by constructing a virtual peptide library and establishing a design and screening method to select and evaluate tetrapeptides with melanin inhibitory activity. Based on a virtual peptide library, technologies such as molecular docking, activity prediction, and force analysis were used to screen the target active tetrapeptides, and then solid-phase peptide synthesis was employed for directed synthesis of the target tetrapeptides. The efficacy of the target active tetrapeptides was further evaluated from biochemical detection, cell models, and molecular transcription perspectives. Four tetrapeptides are selected: Peptide-1 （CHWH）, Peptide-2 （RVGW）, Peptide-3 （LHSY）, and Peptide-4 （LFSY）. Compared to the other three tetrapeptides, Peptide-1 exhibits better Cu2+ chelation, ABTS positive ion scavenging, and tyrosinase inhibitory activity. The IC50 values for tyrosinase activity and melanin production inhibition in B16 cell models are 0.28 and 0.20 g/L, respectively, and it dose not significantly affect cell proliferation below a mass concentration of 10 g/L. Transcriptional studies also further show that Peptide-1 can decrease the intracellular levels of MITF （microphthalmia-associated transcription factor） and TYR （tyrosinase） gene expression in a concentration ration-dependent manner. 数据和表 | 参考文献 | 相关文章 | 计量指标

开发与应用

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羊脐带提取物的制备工艺及其抗炎功效探究 Exploration of the preparation process and anti-inflammatory effects of sheep umbilical cord extract 屈艳玲, 李阿峰, 董玲娟, 王哲, 尚冯青, 明磊国 2026 (4):  479-486.  doi: 10.3969/j.issn.2097-2806.2026.04.008 摘要 ( 70 )   HTML ( 4 )   PDF(2699KB) ( 108 )   通过酶解、均质、超声、过滤纯化等多步分离纯化工艺获得羊脐带提取物（Sheep umbilical cord extract，S-UCE），Bicinchoninic acid （BCA）法蛋白浓度测定显示S-UCE的蛋白质量浓度为（1.64±0.37） mg/mL；利用MTT比色法测定S-UCE对人真皮成纤维细胞（HDF）、人永生化表皮细胞（HaCaT）、小鼠单核巨噬细胞白血病细胞（RAW264.7）的增殖影响，结果显示0~400 μg/mL蛋白质量浓度范围内的S-UCE均未表现出细胞毒性，且对上述细胞显示出50%~100%的促增殖作用；利用脂多糖（Lipopolysaccharide，LPS）诱导的RAW264.7巨噬细胞炎症模型，通过显微镜观察细胞形态学改变，结合Griess试剂法检测细胞培养液中一氧化氮（NO）释放量，并借助ELISA定量分析其中的细胞肿瘤坏死因子TNF-α、白细胞介素IL-6、IL-1β等促炎因子的表达量，在此基础上，进一步采用蛋白印迹法和免疫荧光法检测RAW264.7细胞中极化标志物CD86 （M1型）和CD206 （M2型）的蛋白表达。结果表明：50~200 μg/mL蛋白质量浓度范围内的S-UCE能显著抑制LPS诱导的RAW264.7巨噬细胞形态改变，降低NO的生成，抑制IL-6，IL-1β和TNF-α的表达，其中蛋白质量浓度为100 μg/mL的S-UCE效果最佳，能够下调CD86的蛋白相对表达量，增加CD206的蛋白表达。 In this study, sheep umbilical cord extract （S-UCE） was obtained through a multi-step purification process involving enzymatic hydrolysis, homogenization, ultrasonication and filtration. The protein mass concentration of S-UCE, as determined by the bicinchoninic acid （BCA） assay, was （1.64±0.37） mg/mL. The effect of S-UCE on cell viability of human dermal fibroblasts （HDFs）, human immortalized keratinocytes （HaCaT）, and RAW 264.7 macrophages were evaluated using the MTT colorimetric assay. Results demonstrate that S-UCE at protein mass concentrations ranging from 0 to 400 μg/mL exhibit no cytotoxicity and promote cell proliferation by 50%-100% in the aforementioned cell lines. An inflammatory model was established using lipopolysaccharide （LPS） -stimulated RAW264.7 cells. Morphological changes were observed using microscope, while nitric oxide （NO） release in the culture supernatant was quantified using the Griess reagent method. Enzyme-linked immunosorbent assay （ELISA） was employed to measure the expression levels of pro-inflammatory cytokines, including tumor necrosis factor-alpha （TNF-α）, interleukin （IL） -6, and IL-1β. Furthermore, western blotting and immunofluorescence assays were performed to detect the protein expression of polarization markers CD86 （M1 phenotype） and CD206 （M2 phenotype） in RAW264.7 cells. The results indicate that S-UCE at protein mass concentrations of 50-200 μg/mL significantly attenuate LPS-induced morphological alterations in RAW264.7 cells, reduce NO production, and suppress the expression of IL-6, IL-1β, and TNF-α. Notably, S-UCE at 100 μg/mL exhibits the most potent anti-inflammatory effects, downregulating the relative protein expression of CD86 while upregulating CD206 expression. These findings demonstrate that the prepared S-UCE possesses favorable biosafety and anti-inflammatory properties, providing an experimental foundation for the development of novel animal-derived functional ingredients in cosmetic applications. 数据和表 | 参考文献 | 相关文章 | 计量指标

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一种中药生发液的毛囊刺激性及防脱生发功效探究 Exploration of hair follicle irritation and hair growth efficacy of a Traditional Chinese Medicine hair growth solution 邹枫, 张荣, 陆颖珊, 吴汶丰, 梁家芬, 李红毅 2026 (4):  487-496.  doi: 10.3969/j.issn.2097-2806.2026.04.009 摘要 ( 89 )   HTML ( 11 )   PDF(4369KB) ( 77 )   观察同一中药生发液在7种不同提取方式下对毛乳头细胞、角质形成细胞及离体毛囊的影响作用，探究何种提取方式具有促毛发生长作用的同时对细胞的毒性损害较小。利用MTT法检测7种提取液对毛乳头细胞和角质形成细胞的毒性及增殖作用。选择增殖实验中72 h时间点细胞活力提升效果较好的3种提取液进行离体毛囊实验，观察毛囊毛干的增长及毛囊生长周期的变化。最后通过液相色谱-质谱联用技术构建中药组方的指纹图谱，并鉴定主要的化学成分。结果显示7味药水提醇沉，3味药醇提再加上15 μL挥发油的提取方式（G提取液）对离体毛囊毛干的增长具有显著的促进作用，对毛囊的生长周期具有调节作用，可延长毛囊的生长期、减缓退行期以达到防脱生发的功效。 This study observed the effects of the same Traditional Chinese Medicine combination on hair papilla cells, keratinocytes, and isolated hair follicles under 7 different extraction methods, and explored which extraction method promotes the effect of promoting hair growth while causing less toxic damage to cells. The MTT assay was used to detect the toxicity and proliferative effects of the seven extraction solutions on dermal papilla cells and keratinocytes. Three extraction solutions with better cell viability enhancement effects at the 72-hour time point in the proliferation experiment were selected for hair follicle culture in vitro, and the growth of hair follicles and changes in hair follicle growth cycle were observed. Finally, the fingerprint spectrum of the Traditional Chinese Medicine formula was constructed using liquid chromatography-mass spectrometry, and the main chemical components were identified. The results show that the extraction method for 7 medicinal herbs with alcohol precipitation, and 3 medicinal herbs with alcohol extraction combined with 15 μL of volatile oil （G extraction solution） has a significant promoting effect on the growth of hair follicles in vitro. It also has a regulatory effect on the growth cycle of hair follicles by prolonging the growth period and slowing the degeneration period, thereby achieving hair growth. 数据和表 | 参考文献 | 相关文章 | 计量指标

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重组贻贝粘蛋白改善雄激素脱发效果的体外评价及 机制研究 Evaluation of the efficacy of recombinant mussel adhesive protein in improving androgenetic alopecia and study on its mechanism in vitro 张秋, 张娅, 王蓉, 侯增淼, 黄文涛, 杨鹭 2026 (4):  497-504.  doi: 10.3969/j.issn.2097-2806.2026.04.010 摘要 ( 97 )   HTML ( 2 )   PDF(1366KB) ( 97 )   通过体外实验探究重组贻贝粘蛋白改善雄激素性脱发（AGA）的效果及机制。通过分子量和蛋白含量分析对重组贻贝粘蛋白进行结构表征；考察了不同质量浓度重组贻贝粘蛋白对Ⅱ型5α-还原酶抑制率、人毛发真皮乳头细胞（HDPCs）活力的影响以及在二氢睾酮（DHT）诱导的AGA细胞模型中，考察了炎症因子、生长调节因子（VEGF和HGF）分泌及活性氧（ROS）含量和细胞衰老标志物β-半乳糖苷酶（SA-β-gal）活性的变化，从多维度验证其抗雄激素脱发功效。结果表明，重组贻贝粘蛋白的实测分子量（22 681.366 Da）与理论值高度吻合，且三批原料纯度均超90%，确保了后续功能研究的可靠性。对其功能研究发现，重组贻贝粘蛋白对Ⅱ型5α-还原酶有抑制作用（IC50=1 500 μg/mL），且呈剂量效应关系。此外，在对人毛发真皮乳头细胞（HDPCs）的影响方面，重组贻贝粘蛋白能促进HDPCs细胞增殖并表现为浓度依赖性，且在高浓度下无毒性；进一步研究表明，其通过抑制DHT诱导的ROS生成，减少IL-6和TNF-α等促炎因子释放，同时显著降低SA-β-gal表达，延缓HDPCs细胞早衰，维持其增殖潜力，进而发挥毛发生长促进作用，且在低浓度处理下效果与米诺地尔相当。 The study aims to investigate the effects and mechanisms of recombinant mussel adhesive protein on improving androgenetic alopecia （AGA） through in vitro experiments. The recombinant mussel adhesive protein was structurally characterized through molecular weight and protein content analysis. The effects of different mass concentrations of recombinant mussel mucin on type II 5α-reductase inhibition, human dermal papilla cell （HDPCs） viability were examined, and in the DHT-induced AGA cell model, the changes in inflammation factors, growth regulatory factors （VEGF and HGF） secretion, reactive oxygen species （ROS） levels, and cellular senescence marker β-galactosidase （SA-β-gal） activity were assessed, verifying its anti-androgenetic alopecia efficacy from multiple dimensions. The results show that the measured molecular weight of recombinant mussel adhesive protein （22 681.366 Da） is highly consistent with the theoretical value, and the purity of three batches of raw materials all exceeds 90%, which ensures the reliability of subsequent functional studies. Functional studies on recombinant mussel adhesive protein reveal that it exhibits an inhibitory effect on type II 5α-reductase （IC50 = 1 500 μg/mL） with a dose-dependent relationship. Furthermore, regarding its effect on HDPCs cell, recombinant mussel adhesive protein can promote the proliferation of HDPCs in a concentration-dependent manner without toxicity at high concentrations. Further studies indicate that recombinant mussel adhesive protein exerts a hair growth-promoting effect by inhibiting DHT-induced ROS production, reducing the release of pro-inflammatory factors such as IL-6 and TNF-α, while significantly decreasing the expression of SA-β-gal to delay the premature senescence of HDPCs and maintain their proliferation potential. Notably, the efficacy of recombinant mussel adhesive protein at low concentrations is comparable to that of minoxidil. 数据和表 | 参考文献 | 相关文章 | 计量指标

专论与综述

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油气田开采垢下腐蚀的形成机制及其防护技术研究进展 Research progress on the formation mechanism and protection technologies of under-deposit corrosion in oil and gas field development 白小勇, 李楷, 杨乐, 刘顶将, 吴春生, 燕永利 2026 (4):  505-517.  doi: 10.3969/j.issn.2097-2806.2026.04.011 摘要 ( 69 )   HTML ( 0 )   PDF(20138KB) ( 48 )   垢下腐蚀（Under‐deposit corrosion，UDC）因“隐蔽性强、演变快、破坏性大”而成为油气生产设施完整性管理的关键难题。其形成机制涉及电化学、微生物及物理屏障等多重因素的耦合作用。文章系统综述了垢下腐蚀的演变历程、作用机理及其主要影响因素，重点分析了垢层类型、电化学行为、微生物活动及环境参数对腐蚀过程的协同影响。在此基础上，总结了当前常用的阻垢剂与缓蚀剂等防护技术的应用现状与作用机制，并探讨了其在实际工况中的适用性与局限性。最后对未来垢下腐蚀防护研究的发展方向提出了展望，旨在为油气田腐蚀控制提供理论依据与技术支撑。 Under-deposit corrosion （UDC） is a critical challenge in the integrity management of oil and gas production facilities because it is hidden, rapid-evolving and highly destructive. Its formation mechanism involves the interplay of multiple factors, including electrochemical, microbial, and physical barrier effects. In this review, the evolution process, mechanisms, and main influencing factors of under-deposit corrosion were systematically summarized. The synergistic effects of deposit types, electrochemical behavior, microbial activity, and environmental parameters on the corrosion process were analyzed. On this basis, the current status of application and the mechanisms were summarized for commonly used protection technologies such as scale inhibitors and corrosion inhibitors, as well as their applicability and limitations in practical working conditions. Finally, the future research directions for preventing under-deposit corrosion were proposed, aiming to provide theoretical basis and technical support for corrosion control in oil and gas fields. 数据和表 | 参考文献 | 相关文章 | 计量指标

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LCO高效催化裂化制取高价值BTX芳烃研究进展 Research progress on the efficient catalytic cracking of LCO to produce high-value BTX aromatics 于佳欢, 宋艳新, 陈光 2026 (4):  518-528.  doi: 10.3969/j.issn.2097-2806.2026.04.012 摘要 ( 64 )   HTML ( 0 )   PDF(1816KB) ( 48 )   随着国内柴汽比逐年降低、环保法规及车用柴油质量标准日益严苛，其中国Ⅵ柴油的质量标准要求多环芳烃（PAHs）的含量不得超过7%，催化裂化柴油（LCO）由于芳烃含量高导致其有效利用成为炼化企业的关键问题。而经济和社会的快速发展推动苯、甲苯和二甲苯（BTX）需求逐年上升，BTX等低碳芳烃作为重要的化工原料供不应求。因此，加氢裂化技术（HYC）成为化解柴油产能过剩、拓宽轻质芳烃等高附加值产品来源的重要途径。本文针对国内外的LCO制取轻质芳烃的工艺技术、LCO制取轻质芳烃的原理、催化剂的研究现状以及催化剂传质扩散对加氢裂化的影响4个方面进行了介绍，同时提出结合催化剂及其分子筛孔道中的扩散性能研究将有助于催化剂的优化设计，实现LCO高效加氢裂化制BTX。 The shifting landscape of China’s fuel market, characterized by a declining diesel-to-gasoline ratio and the rigorous enforcement of China VI diesel standards, has intensified the challenge of optimizing light cycle oil （LCO） utilization. The trend of diesel overcapacity coincides with a growing supply-demand imbalance in key petrochemical building blocks, namely benzene, toluene, and xylene （BTX）. In this context, hydrocracking （HYC） is increasingly recognized as a pivotal upgrading technology to address both issues simultaneously: alleviating the diesel surplus while selectively producing high-value BTX aromatics. This review provides a systematic analysis of contemporary technologies for the catalytic transformation of LCO into BTX. We delve into the fundamental reaction mechanisms, including hydrogenation, ring-opening, and dealkylation, which govern the selectivity towards light aromatics. A particular focus is placed on recent advancements in bifunctional catalyst design, in which the delicate balance between metal function and zeolite acidity is critical for directing the reaction pathway. Furthermore, we critically analyze the often-overlooked aspect of mass transfer and diffusion limitations within catalyst particles and zeolite micropores. A profound understanding of molecular diffusion is paramount for the rational design of next-generation catalysts, ultimately enabling the highly efficient and selective conversion of low-value LCO into premium BTX products via hydrocracking. 数据和表 | 参考文献 | 相关文章 | 计量指标

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硫酸皮肤素在皮肤组织中的生理功能与应用 Physiological functions and applications of dermatan sulfate in skin tissue 王峥, 钱佳俊, 樊雨梅, 凌沛学 2026 (4):  529-538.  doi: 10.3969/j.issn.2097-2806.2026.04.013 摘要 ( 80 )   HTML ( 5 )   PDF(4202KB) ( 62 )   硫酸皮肤素（Dermatan sulfate, DS）是一种由N-乙酰半乳糖胺（GalNAc）与糖醛酸交替连接而成的糖胺聚糖，具有显著的结构异质性和高负电荷密度，能够与多种蛋白质发生特异性相互作用，广泛参与组织发育、损伤修复、炎症调控等关键生理与病理过程。皮肤中，DS通过调控胶原纤维组装、影响细胞信号传导和介导细胞黏附，在维持皮肤机械强度、促进伤口愈合和抗衰老等方面发挥关键作用。近年来，随着对DS生物学功能研究的深入，其在皮肤健康与疾病干预领域的应用潜力日益凸显。本文系统梳理了DS在皮肤组织工程、创面愈合、抗纤维化和抗老化等前沿领域的最新研究进展，剖析了DS构象灵活性（由艾杜糖醛酸介导）及其特定硫酸化模式如何调控皮肤生物功能的核心机制，以期为相关基础研究的转化与创新产品开发提供理论依据和新思路。 Dermatan sulfate （DS） is a glycosaminoglycan composed of alternating N-acetylgalactosamine （GalNAc） and uronic acid residues. Characterized by significant structural heterogeneity and high negative charge density, DS interacts specifically with diverse proteins, widely participating in critical physiological and pathological processes including tissue development, injury repair, and inflammation regulation. In the skin, DS plays a pivotal role in maintaining mechanical strength, promoting wound healing, and combating aging by regulating collagen fibril assembly, modulating cell signaling, and mediating cell adhesion. In recent years, with deepening research into its biological functions, the application potential of DS in skin health management and disease intervention has become increasingly prominent. This review systematically summarizes the latest research progress of DS in the frontier fields such as skin tissue engineering, wound healing, anti-fibrosis, and anti-aging. Furthermore, it dissects the core mechanisms by which DS conformational flexibility （mediated by iduronic acid） and specific sulfation patterns regulate cutaneous biological functions, aiming to provide a theoretical basis and novel insights for the translation of basic research and the development of innovative products. 数据和表 | 参考文献 | 相关文章 | 计量指标

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油茶在日用化学品领域的研究进展和发展趋势 Research progress and prospects of Camellia oleifera in the field of daily chemicals 李孟洋, 李劲博, 黄卫娟 2026 (4):  539-544.  doi: 10.3969/j.issn.2097-2806.2026.04.014 摘要 ( 88 )   HTML ( 2 )   PDF(4760KB) ( 87 )   油茶是我国重要的经济作物，广泛分布于南方多省且品种多样。其核心产品油茶籽油不仅富含不饱和脂肪酸，还含有维生素E、角鲨烯等生物活性成分。值得注意的是，油茶的花、壳、籽等主要组成部分具备独特的结构特征与潜在价值。油茶花的天然活性物质、油茶壳的多孔吸附结构以及油茶籽的优质成分，共同奠定了油茶在日用化学品领域的应用基础。这些特性使油茶在护肤品、清洁产品等日用化学品领域展现出巨大的开发潜力与市场前景，亟待通过系统性的深入研究以实现其资源的高值化开发与产业化转化。 Camellia oleifera Abel., a vital economic tree species in China, is extensively cultivated across southern provinces and comprises more than 100 documented cultivars. Its primary product, camellia oil, is rich in unsaturated fatty acids and contains bioactive components such as vitamin E and squalene, which exhibit excellent antioxidant and long-lasting moisturizing effects, as demonstrated in preliminary studies. Beyond the oil, other parts of the plant, flowers, fruit shells, and seeds, also offer significant application potential due to their distinct structural and chemical characteristics. Flower extracts, rich in flavonoids, provide anti-inflammatory and soothing effects for sensitive skin. Pyrolyzed or enzymatically treated fruit shells form porous structures with high adsorption capacity, making them suitable as natural cleaning agents. Additionally, camellia seed proteins, which account for about 10% of the seed content, serve as nutritional additives in skincare formulations to support skin barrier function. Collectively, these attributes support the integration of C. oleifera in moisturizing skincare, natural cleansers, anti-aging serums, and hair care products. However, the comprehensive development and utilization of this resource remain in the early stages. Current research predominantly focuses on individual components, with limited exploration of synergistic applications. Systematic investigations are urgently needed to address key challenges, including efficient extraction of active ingredients, robust efficacy validation through in vitro and in vivo testing, and formulation optimization for product stability. Advancing these areas will facilitate industrial transformation, extend the value chain, reduce resource waste, and generate substantial economic and ecological benefits. This review systematically summarizes the phytochemical composition, functional properties, and industrial applications of C. oleifera in daily chemical products. 数据和表 | 参考文献 | 相关文章 | 计量指标

分析与检测

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基于石墨烯固相萃取-二维高效液相色谱串联质谱检测化妆品中9种β受体阻滞剂 Detection of nine β-blockers in cosmetics via graphene-based solid-phase extraction coupled with two-dimensional high-performance liquid chromatography-tandem mass spectrometry 刘益庆, 陈洪岩, 魏明, 徐祎璘 2026 (4):  545-550.  doi: 10.3969/j.issn.2097-2806.2026.04.015 摘要 ( 62 )   HTML ( 1 )   PDF(2547KB) ( 77 )   采用磁性石墨烯固相萃取结合二维高效液相色谱串联质谱技术，建立化妆品中阿替洛尔等9种β受体阻滞剂检测方法。样品经过乙腈溶液提取，以磁性石墨烯为固相萃取吸附剂吸附目标物，采用二维液相色谱-串联质谱仪分析，标准曲线外标法定量。结果表明：磁性石墨烯用量8 mg，吸附20 min，以5 mL乙腈溶液为洗脱液，可实现9种β受体阻滞剂富集和纯化，目标物在水剂、乳液、膏霜剂3种不同基质中质量浓度为50~800 ng/mL及100~1 600 ng/mL范围内线性关系良好，相关系数 （r） 均大于0.999 1，平均回收率分别为90.32%~100.11%，90.26%~102.22%，90.42%~102.02%。该方法专属性强，灵敏度高，重现性好，适用于复杂化妆品体系中9种β受体阻滞剂的检测。 This study established a method for the determination of nine β-blockers, including atenolol, in cosmetics using magnetic graphene solid-phase extraction coupled with two-dimensional high performance liquid chromatography tandem mass spectrometry. The samples were extracted with acetonitrile solution, and the targets were adsorbed with magnetic graphene as the solid phase extraction adsorbent. The samples were analyzed by two-dimensional liquid chromatography-tandem mass spectrometry （2D-LC-MS/MS）, and quantified by the standard curve external standard method. The findings indicate that a dosage of 8 mg of magnetic graphene, in conjunction with an adsorption period of 20 minutes and the utilization of a 5 mL acetonitrile solution as the eluent, can effectively achieve the enrichment and purification of nine β-blockers. The targets exhibit satisfactory linearity across three distinct matrices: aqueous, emulsion, and cream, within the mass concentration ranges of 50-800 ng/mL and 100-1 600 ng/mL, with the correlation coefficients （r） all greater than 0.999 1. The mean recoveries is found to range from 90.32% to 100.11%, 90.26% to 102.22%, and 90.42% to 102.02%, respectively. The method is characterized by high specificity, high sensitivity, and good reproducibility, and is suitable for the determination of nine β-blockers in complex cosmetic systems. 数据和表 | 参考文献 | 相关文章 | 计量指标

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UPLC-MS/MS法测定化妆品中17种有机酸 Determination of 17 kinds of organic acids in cosmetic products by UPLC-MS/MS 伍志航, 罗敏婷, 黄楚雯 2026 (4):  551-556.  doi: 10.3969/j.issn.2097-2806.2026.04.016 摘要 ( 63 )   HTML ( 1 )   PDF(1673KB) ( 76 )   建立了超高效液相色谱-串联质谱法（UPLC-MS/MS）测定化妆品中17种有机酸的分析方法。化妆品样品用50% （V/V）甲醇水溶液超声提取溶解后，样液在色谱柱Welch Ultimate AQ-C18 （2.1 mm×100 mm，1.8 μm）经0.01%甲酸水溶液-甲醇的流动相梯度洗脱分离，质谱检测器采用多反应监测（MRM）模式检测，根据保留时间和特征离子对的相对丰度比定性，定量离子对峰面积定量，以基质曲线外标法定量。在包括膏霜乳、液体、凝胶的多种基质类型中17种有机酸在各自定量范围内线性关系良好（R2 > 0.99），检出限为0.101 3~5.215 μg/g，定量限为0.303 9~15.64 μg/g，低、中、高3个浓度加标水平下，各基质样品平均回收率范围为97.2%~106%，相对标准偏差（n=6）范围为1.5%~8.5%。该方法前处理操作简便、分析效率高、灵敏度高、定量准确、重现性强，适用于各种类型化妆品中17种有机酸的检测。 A method based on ultra-performance liquid chromatography-tandem mass spectrometry （UPLC-MS/MS） was established for the determination of 17 organic acids in cosmetics. Cosmetic samples were extracted with 50% （V/V） methanol-water solution. The sample solution was separated on a Welch Ultimate AQ-C18 （2.1 mm× 100 mm, 1.8 μm） using 0.01% formic acid in water and methanol as the mobile phases under gradient elution. Mass spectrometry detection was performed in multiple reaction monitoring （MRM） mode. Qualitative analysis was based on retention time and relative abundance ratio of characteristic ion pairs, while quantitative analysis was carried out using the peak areas of quantitative ion pairs. Quantification was performed by the matrix-matched external standard method using calibration curves. For various matrix types, including creams, lotions, liquids, and gels, the 17 organic acids exhibit good linearity within their respective concentration ranges （R2 > 0.99）. The limits of detection （LODs） range from 0.101 3-5.215 μg/g, and the limits of quantification （LOQs） range from 0.303 9-15.64 μg/g. At three spiked concentration levels （low, medium, and high）, the recoveries of the target analytes in different matrix samples range from 92.7% to 106%, with relative standard deviations （RSDs, n=6） of 1.5%-8.5%. This method features simple sample preparation, high analytical efficiency, high sensitivity, accurate quantification, and strong reproducibility, and is suitable for the determination of the 17 organic acids in various cosmetic products. 数据和表 | 参考文献 | 相关文章 | 计量指标