一种降低月桂醇聚醚硫酸酯钠刺激性的清洁组合物性能研究

doi:10.3969/j.issn.2097-2806.2026.07.010

摘要/Abstract

摘要：

以月桂醇聚醚硫酸酯钠（AES）为研究目标，采用红细胞溶血试验、玉米醇溶蛋白溶解试验、鸡胚绒毛尿囊膜试验对AES复配体系刺激性进行研究。结果表明，磺酸羟丙酯月桂基葡糖苷交联聚合物钠（HLC）、椰油酰谷氨酸二钠（UCS）及PEG-80失水山梨醇月桂酸酯（Tween 28）对AES刺激性改善较明显。动态光散射正交试验分析结果显示：影响最大因素为HLC，其次为Tween 28，UCS影响最小，HLC、Tween 28和UCS的添加量均为4%为体系较优组合；泡沫高度正交试验分析结果显示：影响最大因素Tween 28及UCS，HLC影响最小，HLC、Tween 28和UCS的添加量分别为4%，2%和1%为体系较优组合。综合正交试验k值大小分析，确定AES复配体系为4% HLC、4% Tween 28及1% UCS，该组合通过空间位阻与静电斥力的协同作用增大胶束粒径，从而降低AES复配体系刺激性，同时保持丰富泡沫，平衡体系的温和清洁与泡沫丰富度。

关键词: 月桂醇聚醚硫酸酯钠, 刺激性, 胶束粒径, 正交试验

Abstract:

Focusing on sodium laureth sulfate（AES）, the irritancy of the AES complex system was studied using red blood cell hemolysis test, zein test, and chicken embryo chorioallantoic membrane test. The results show that sodium hydroxypropyl sulfonate glucoside cross-linked polymer（HLC）, disodium cocoyl glutamate（UCS）, and PEG-80 sorbitan laurate（Tween 28）significantly mitigated the irritancy of AES. The results of dynamic light scattering orthogonal experiment analysis show that the most influential factor is HLC, followed by Tween 28, with UCS having the least impact, with the corresponding optimal combination of being 4% HLC, 4% Tween 28, and 4% UCS. The orthogonal analysis of foam height shows that the most influential factors are Tween 28 and UCS, while HLC has the least influence, yielding an optimal combination of 4% HLC, 2% Tween 28, and 1% UCS. Based on the comprehensive analysis of the value of k in the orthogonal tests, the comprehensive optimal AES complex system is determined to be 4% HLC, 4% Tween 28 and 1% UCS. This combination increases the micelle size through the synergistic effect of steric hindrance and electrostatic repulsion, thereby reducing the irritation of the AES complex system, while maintaining abundant foam, effectively balancing the contradiction between system mildness, cleansing performance, and foaming capability.

Key words: sodium laureth sulfate, thrill, micellar particle size, orthogonal experiment

中图分类号:

TQ423

吴明城, 李靖, 伍丽诗, 谢怀统, 史学东, 周攀峰. 一种降低月桂醇聚醚硫酸酯钠刺激性的清洁组合物性能研究[J]. 日用化学工业（中英文）, 2026, 56(7): 919-924.

Mingcheng Wu, Jing Li, Lishi Wu, Huaitong Xie, Xuedong Shi, Panfeng Zhou. Study on the performance of a low-irritation cleaning composition with reducing the irritancy of sodium laureth sulfate[J]. China Surfactant Detergent & Cosmetics, 2026, 56(7): 919-924.

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水平	因素
水平	A w（HLC）/%	B w（Tween 28）/%	C w （UCS）/%	D w（AES）/%
1	4	4	4	8
2	2	2	2	8
3	1	1	1	8

实验编号	因素				胶束粒径/nm	泡沫高度/mm
实验编号	A	B	C	D	胶束粒径/nm	泡沫高度/mm
1	1	1	1	1	11.01	141
2	1	2	2	2	6.69	148
3	1	3	3	3	10.35	143
4	2	1	2	3	7.25	145
5	2	2	3	1	3.61	146
6	2	3	1	2	4.18	135
7	3	1	3	2	4.77	145
8	3	2	1	3	4.49	141
9	3	3	2	1	4.02	140

实验编号	因素
实验编号	A	B	C
K₁	28.05	23.03	19.68
K₂	15.04	14.79	17.96
K₃	13.28	18.55	18.73
k₁	9.35	7.68	6.56
k₂	5.01	4.93	5.99
k₃	4.43	6.18	6.24
R	4.92	2.75	0.57

方差来源	离差平方和	自由度	均方	F值	P值	显著性
HLC	43.390	2	21.695	6.248	0.138	无显著性
Tween 28	11.345	2	5.673	1.634	0.380	无显著性
UCS	0.495	2	0.247	0.071	0.933	无显著性
误差	6.945	2	3.472

实验编号	因素
实验编号	A	B	C
K₁	432	431	417
K₂	426	435	432
K₃	426	418	434
k₁	144	144	139
k₂	142	145	144
k₃	142	139	145
R	2	6	6