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日用化学工业（中英文）

日用化学工业（中英文） ›› 2026, Vol. 56 ›› Issue (6): 717-728.doi: 10.3969/j.issn.2097-2806.2026.06.003

• 基础研究 • 上一篇    下一篇

硫原子位点调控增强有机光热剂抗菌性能

秦涛1,黄鑫1,崔效源1,李芬芳1,杜意恩1,郝俊生2,*()   

  1. 1 晋中学院 化学化工系， 山西 晋中 030619
    2 山西大学 化学化工学院， 山西 太原 030006
  • 收稿日期:2026-02-03 修回日期:2026-06-11 出版日期:2026-06-22 发布日期:2026-07-22
  • 基金资助:
    山西省高等学校科技创新项目(2024L346)

Enhancing antibacterial efficacy of organic photothermal agents via site regulation of sulfur atom

Tao Qin1,Xin Huang1,Xiaoyuan Cui1,Fenfang Li1,Yien Du1,Junsheng Hao2,*()   

  1. 1 Department of Chemistry and Chemical Engineering, Jinzhong University, Jinzhong, Shanxi 030619, China
    2 College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, Shanxi 030006, China
  • Received:2026-02-03 Revised:2026-06-11 Online:2026-06-22 Published:2026-07-22
  • Contact: *E-mail: jshao@sxu.edu.cn

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摘要：

为探究硫原子精确位置对有机光热剂性能的影响，该文对比了两个具有给体-受体（D-A）结构的共轭小分子S-1和S-2，唯一的结构差异在于噻吩[3, 4-b]单元中单个硫原子的位置。理论计算结果表明，与S-1相比，S-2中硫原子的位置变化使其分子的二面角减小，分子平面度增高，HOMO-LUMO间隙减小（S-2为1.90 eV，S-1为2.10 eV）。光学表征显示，S-2在四氢呋喃中的最大吸收峰为770 nm，制备为纳米粒子（S-2 NPs）后红移至780 nm。光热性能测试中，S-2 NPs在808 nm激光照射下的光热转换效率为52%，高于S-1 NPs的44%。在抗菌实验中，在激光照射下，浓度为12 μmol/L时，S-2 NPs对金黄色葡萄球菌的杀菌率达99.1% （S-1 NPs为43.8%），15 μmol/L的S-2 NPs对大肠杆菌的杀菌率达99.9% （S-1 NPs为43.4%），20 μmol/L的S-2 NPs对白色念珠菌的杀菌率达96.0% （S-1 NPs为83.8%），并可有效清除金黄色葡萄球菌生物膜（40 μmol/L时存活率仅为16%）。细胞实验表明，S-2 NPs在40 μmol/L浓度下，L929细胞活力仍保持在80%以上。因此，S-2 NPs被认为是一种极具前景的光热剂。研究表明，对单个硫原子位置进行精准调控是一种提升有机光热剂光热转换效率和抗菌性能的有效策略。S-2 NPs具有优越的光热抗菌性能和良好的生物相容性，可以被加入到化妆品面霜、乳液或面膜中，以赋予光热抗菌功能，为延长产品保质期和增强皮肤健康提供种新的策略。

关键词: 有机光热剂, 硫原子, 能级差, 光热转换效率, 抗菌, 化妆品

Abstract:

To elucidate the effect of precise sulfur-atom positioning on the performance of organic photothermal agents, this work compares two conjugated donor-acceptor （D-A） small molecules, S-1 and S-2, which differ only in the position of a single sulfur atom in the thiophene [3, 4-b] unit. Theoretical calculations revealed that compared to S-1, the altered sulfur atom position in S-2 reduced the dihedral angle, increased molecular planarity, and decreased the HOMO-LUMO gap （1.90 eV for S-2 and 2.10 eV for S-1）. Optical characterization showed that S-2 exhibited a maximum absorption peak at 770 nm in tetrahydrofuran, which was red-shifted to 780 nm when it was prepared as nanoparticles （S-2 NPs）. Photothermal performance tests demonstrated that S-2 NPs achieved a 52% photothermal conversion efficiency under 808 nm laser irradiation, surpassing the 44% of S-1 NPs. In antibacterial experiments, under laser irradiation, S-2 NPs at 12 μmol/L achieved a 99.1% bacterial killing rate against Staphylococcus aureus （43.8% for S-1 NPs）, 15 μmol/L S-2 NPs reached 99.9% against Escherichia coli （43.4% for S-1 NPs）, and 20 μmol/L S-2 NPs attained 96.0% against Candida albicans （83.8% for S-1 NPs）, effectively eliminating Staphylococcus aureus biofilms （survival rate was only 16% at 40 μmol/L）. Cell experiments indicated that S-2 NPs maintained over 80% L929 cell viability at 40 μmol/L. Thus, S-2 NPs are considered a highly promising photothermal agent. The study demonstrates that precise control over individual sulfur atom positions is an effective strategy for enhancing photothermal conversion efficiency and antibacterial performance in organic photothermal agents. With superior photothermal antibacterial properties and excellent biocompatibility, S-2 NPs can be incorporated into cosmetic face creams, lotions, or facial masks to impart photothermal antibacterial functionality, offering a novel strategy for extending product shelf life and improving skin health.

Key words: organic photothermal agent, sulfur atom, energy gap, photothermal conversion efficiency, antibacterial, cosmetics

中图分类号: 

  • O692