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日用化学工业（中英文）

日用化学工业（中英文） ›› 2026, Vol. 56 ›› Issue (3): 302-313.doi: 10.3969/j.issn.2097-2806.2026.03.004

• 基础研究 • 上一篇    下一篇

油莎草根油对抑制TNF-α诱导的人真皮成纤维细胞炎症和衰老的研究

张婉萍1,王嘉怡1,贾东晗1,莫美玲2,梁莹3,彭常梅1,*(),王玥1,*()   

  1. 1 上海应用技术大学 香料香精化妆品学部， 上海 201418
    2 中山中研化妆品有限公司， 广东 中山 528400
    3 科斯美医药（上海）有限责任公司， 上海 201400
  • 收稿日期:2025-08-11 修回日期:2026-03-02 出版日期:2026-03-22 发布日期:2026-05-14
  • 通讯作者: 彭常梅,王玥

Study on the inhibition of TNF-α-induced inflammation and aging in human skin fibroblast cells by Cyperus esculentus root oil

Wanping Zhang1,Jiayi Wang1,Donghan Jia1,Meiling Mo2,Ying Liang3,Changmei Peng1,*(),Yue Wang1,*()   

  1. 1 School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China
    2 Zhongshan Sinno Cosmetic Co., Ltd, Zhongshan, Guangdong 528400, China
    3 Cosme Pharmaceuticals （Shanghai） Co., Ltd, Shanghai 201400, China
  • Received:2025-08-11 Revised:2026-03-02 Online:2026-03-22 Published:2026-05-14
  • Contact: Changmei Peng,Yue Wang

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摘要：

本研究首先通过人真皮成纤维细胞（Human Skin fibroblasts，HSF）构建了炎症模型，分别考察了油莎草根油对细胞分泌的炎性因子、Ⅰ型胶原蛋白（Collagen-Ⅰ）和透明质酸（HA）含量的影响。结果表明，油莎草根油在最大安全质量分数6%时，对肿瘤坏死因子-α （TNF-α）诱导的HSF细胞分泌的促炎因子白介素-6、1β （IL-6，IL-1β）有显著抑制（P<0.000 1），抑制率分别为50.79%和20.26%，同时显著促进抗炎因子白介素-10 （IL-10）的分泌（P<0.01），提高率为94.42%。同时，此含量下的油莎草根油显著增加了HSF细胞Col-Ⅰ和透明质酸分泌，分别为26.15%和30.2% （P<0.000 1），具有抗衰和保湿的功效。此外，通过荧光实时定量PCR检测，油莎草根油显著抑制TNF-α诱导HSF细胞的IL-6、IL-1β和MMP-1, 3, 9的mRNA表达，并促进IL-10和HAS-2的mRNA表达，起到抗炎和抗衰老的作用。最后，通过油莎草根油临床评估，进一步评价了其抗炎、抗衰和保湿的功效。综上，油莎草根油作为一种富含不饱和脂肪酸的天然原料，其抗炎、抗衰和保湿的个人护理功效有望在化妆品中得到进一步开发和利用。

关键词: 油莎草根油, 抗炎, 抗衰, 保湿, 个人护理

Abstract:

Cyperus esculentus root oil （CEL） is a plant of significant economic value, rich in unsaturated fatty acids like oleic acid, linoleic acid, and linolenic acid. In this study, human dermal fibroblasts （HSF） were used to create an inflammatory model, and the impact of cold-pressed oil from CEL on the secretion of inflammatory factors was assessed. The results showed that CEL significantly inhibited IL-6 and IL-1β that were secreted by HSF cells induced by tumor necrosis factor-α （TNF-α） （P<0.000 1）, with inhibition rates of 50.79% and 20.26%, respectively. Furthermore, CEL markedly enhanced the secretion of the anti-inflammatory factor IL-10 （P<0.01）, with an improvement rate of 94.42%. The study further explored the impact of CEL on collagen type I （Col-I） and hyaluronic acid （HA） secretion in the cells. The results demonstrated that CEL effectively increased Col-I secretion by 26.15% （P<0.000 1） and HA by 30.2% （P<0.000 1） when it was administered at a maximum safe mass fraction of 6%, which consequently showed its potential anti-aging and moisturizing properties. Additionally, fluorescence real-time quantitative polymerase chain reaction （PCR） experiments confirmed that CEL significantly inhibited the TNF-α-induced expression of IL-6, IL-1β, and matrix metalloproteinases （MMP-1, 3, 9） in HSF cells, while promoted the mRNA expression levels of IL-10 and hyaluronic acid synthase. This modulation suggested that CEL exerted anti-inflammatory and anti-aging effects. Finally, the oil’s anti-inflammatory, anti-senility, and moisturizing effects were validated through the clinical evaluations. In summary, CEL, as a natural raw material abundant in unsaturated fatty acids, shows promising potential for further development and usage in cosmetics due to its anti-inflammatory, anti-aging, and moisturizing properties in personal care.

Key words: Cyperus esculentus root oil, anti-inflammatory, anti-aging, moisturizing, personal care

中图分类号: 

  • TQ658