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日用化学工业（中英文）

日用化学工业（中英文） ›› 2025, Vol. 55 ›› Issue (5): 616-624.doi: 10.3969/j.issn.2097-2806.2025.05.010

• 开发与应用 • 上一篇    下一篇

基于网络药理学探究大花红景天改善皮肤毛细血管扩张症机制

王斌雅1,杨杨2,3,权强华2,3,安全2,3,杨成1,赵炳天1,*()   

  1. 1.合成与生物胶体教育部重点实验室，江南大学 化学与材料工程学院，江苏 无锡 214122
    2.云南白药集团健康产品有限公司，上海 201100
    3.东亚肌肤健康研究中心，北京 100037
  • 收稿日期:2024-05-20 修回日期:2025-05-08 出版日期:2025-05-22 发布日期:2025-06-11
  • 基金资助:
    国家自然科学基金青年科学基金项目(22208121);江苏省自然科学基金青年项目(BK20221069)

Elucidating the potential mechanism of Rhodiola crenulata on improving skin telangiectasia based on network pharmacology

Binya Wang1,Yang Yang2,3,Qianghua Quan2,3,Quan An2,3,Cheng Yang1,Bingtian Zhao1,*()   

  1. 1. Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangnan 214122, China
    2. Yunnan Baiyao Group Shanghai Science & Technology Co., Ltd., Shanghai 201100, China
    3. East Asia Skin Health Research Center, Beijing 100037, China
  • Received:2024-05-20 Revised:2025-05-08 Online:2025-05-22 Published:2025-06-11
  • Contact: *E-mail: btzhao@jiangnan.edu.cn.

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摘要：

基于网络药理学和实验验证研究大花红景天提取物的改善皮肤毛细血管扩张症作用，为其在化妆品、食品等领域的综合利用提供科学依据。运用SymMap和TCMIP数据库获取大花红景天的活性成分，运用Swiss Target Prediction和Genecards数据库得到大花红景天与皮肤毛细血管扩张症相关的靶点，并采用String分析蛋白之间的相互作用以及KEGG信号通路富集。最后通过体外细胞实验初步验证大花红景天改善皮肤毛细血管扩张症的作用。选取14种大花红景天活性成分获得相应靶点253个，皮肤毛细血管扩张症相关靶点2 646个，其中两者交集靶点164个。KEGG通路富集分析结果表明，大花红景天可能通过Ras、VEGF、HIF-1等与血管生成相关的信号通路发挥抑制皮肤毛细血管扩张的作用。体外细胞实验结果显示大花红景天提取物能够显著抑制TNF-α诱导的角质形成细胞（HaCaT）中VEGF的分泌，同时它可以进一步抑制由VEGF诱导人脐静脉内皮细胞（HUVEC）的增殖、迁移和管状结构的生成。

关键词: 大花红景天, 网络药理, 毛细血管扩张, 血管生成

Abstract:

Based on network pharmacology and experimental verification, the improvement of Rhodiola cernulata（R. crenulata） on skin telangiectasia was investigated to provide scientific basis for its comprehensive utilization in cosmetics, food and other fields. The active ingredients of R. cernulata were retrieved from SymMap and TCMIP database. Targets related to R. crenulata and skin telangiectasia were predicted using Swiss Target Prediction and Genecards database. The interactions between proteins were analyzed using String and the KEGG signaling pathways enrichment analysis were performed further. Finally, in vitro cell experiments were used to preliminarily verify the improvement of R. crenulate on skin telangiectasia. A total of 14 active ingredients of R. crenulata are selected to obtain 253 corresponding targets and 2 646 targets related to skin telangiectasia, of which 164 are intersection targets. The results of KEGG pathway enrichment analysis show that R. crenulata may play a role in inhibiting skin telangiectasia through Ras, VEGF, HIF-1, and other signaling pathways related to angiogenesis. In vitro cell experiment results show that R. crenulata extract can significantly inhibit the secretion of VEGF in keratinocytes （HaCaT） induced by TNF-α, and it further inhibit the proliferation, migration and formation of tubular structures of human umbilical can vein endothelial cells （HUVEC） induced by VEGF, which reflect the potential value of R. crenulata in treating skin telangiectasia.

Key words: Rhodiola cernulata, network pharmacology, telangiectasia, angiogenesis

中图分类号: 

  • TQ658