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日用化学工业（中英文）

日用化学工业（中英文） ›› 2026, Vol. 56 ›› Issue (9): 1269-1280.doi: 10.3969/j.issn.2097-2806.2026.09.016

• 分析与检测 • 上一篇    下一篇

GC-MS/MS法测定香精香料及日化产品中83种致敏性香味物质

周梦茜,王嘉乐,陈燕芳,薛诗凡,吴秉宇,吴达*()   

  1. 上海烟草集团有限责任公司技术中心， 上海 201315
  • 收稿日期:2025-11-13 修回日期:2026-08-17 出版日期:2026-09-22 发布日期:2026-09-30

Determination of 83 fragrance allergens in fragrances, flavors, and cosmetic and personal care products by GC-MS/MS

Mengxi Zhou,Jiale Wang,Yanfang Chen,Shifan Xue,Bingyu Wu,Da Wu*()   

  1. Technical Center of Shanghai Tobacco Group Co. Ltd, Shanghai 201315, China
  • Received:2025-11-13 Revised:2026-08-17 Online:2026-09-22 Published:2026-09-30
  • Contact: *E-mail: zmsissi@126.com.

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摘要：

基于气相色谱-串联质谱技术（GC-MS/MS）建立了多种致敏性香味物质的分析方法，适用于同时测定香精香料及日化产品中的83种致敏性香味物质。将样品用丙酮涡旋振荡萃取后，样液过膜后直接液体进样，采用DB-WAX （30 m×0.25 mm×0.25 µm）毛细管色谱柱分离，GC-MS/MS进样分析，在质谱多反应监测（MRM）模式下采集数据，基于保留时间与离子对相对丰度比进行定性，并采用内标法定量分析。结果表明：83种致敏性香味物质在线性范围（0.10~50.00 mg/L）内表现良好的线性相关性，相关系数均大于0.992 0，检出限为0.05~2.35 µg/g，定量限为0.20~7.75 µg/g。在低、中、高三个加标水平下，平均回收率为79.0%~122.5%，相对标准偏差（RSD）为0.1%~8.1% （n=5）。该方法简便、准确度较高，能满足香精香料及日化产品中83种致敏性香味物质的测定。

关键词: 气相色谱-串联质谱, 致敏性香味物质, 内标法, 香精香料, 日化产品

Abstract:

An analytical method based on gas chromatography-tandem mass spectrometry （GC-MS/MS） was established for the simultaneous determination of 83 fragrance allergens in fragrances, flavors, and cosmetic and personal care products. Samples were extracted with acetone via vortex mixing. The extract was filtered, directly injected，and analyzed by GC-MS/MS on a DB-WAX capillary column （30 m×0.25 mm×0.25 µm）. Data acquisition was performed in multiple reaction monitoring （MRM） mode. Qualitative identification was based on retention time and qualifier-to-quantifier ion ratios, while quantitative analysis was carried out using the internal standard method. The results demonstrate that all 83 target analytes exhibit good linearity within their respective mass concentration ranges （0.10-50.00 mg/L）, with correlation coefficients （R2） exceeding 0.992 0. The limits of detection （LODs） range from 0.05 to 2.35 µg/g, and the limits of quantification （LOQs） range from 0.20 to 7.75 µg/g. At three spiked concentration levels （low, medium, and high）, the average recoveries are between 79.0% and 122.5%, with relative standard deviations （RSDs） of 0.1%-8.1% （n=5）. This method is simple, accurate, and suitable for the determination of 83 fragrance allergens in fragrances, flavors, and cosmetic and personal care products.

Key words: gas chromatography-tandem mass spectrometry, fragrance allergens, internal standardization, fragrances and flavors, cosmetic and personal care products

中图分类号: 

  • TQ658