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日用化学工业（中英文）

日用化学工业 ›› 2017, Vol. 47 ›› Issue (9): 522-525.doi: 10.13218/j.cnki.csdc.2017.09.009

• 开发与应用 • 上一篇    下一篇

甘草酸二钾在牙膏中的抑菌作用

陈钢1, 许海燕1,2, 骆朋2   

  1. 1.南昌大学 食品科学学院,江西 南昌 330038;
    2.江西诚志日化有限公司,江西 南昌 330013
  • 收稿日期:2017-06-18 发布日期:2019-03-20
  • 通讯作者: 许海燕,高级工程师,电话:13879116015,E-mail:xhyan980107@163.com。
  • 作者简介:陈 钢(1968-),男,江西赣州人,教授,博士,电话:18070036899,E-mail:zn_chengang@163.com。

Bacteriostasis of di-potassium glycyrrhizate in toothpaste

CHEN Gang1, XU Hai-yan1,2, LUO Peng2   

  1. 1.School of Food Science and Technology,Nanchang University,Nanchang,Jiangxi 330038,China;
    2.Jiangxi Chengzhi Daily Expenses Chemical Co.,Ltd.,Nanchang,Jiangxi 330013,China
  • Received:2017-06-18 Published:2019-03-20

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摘要： 测试了甘草酸二钾对牙龈卟啉单胞菌的最小抑菌浓度,并研究了含0.2%甘草酸二钾的牙膏对牙龈卟啉单胞菌的抑菌作用及对二甲苯致小鼠耳廓肿胀的影响。实验结果表明,甘草酸二钾对牙龈卟啉单胞菌具有抑制作用,最小抑菌浓度为1.875 g/L;含0.2%甘草酸二钾的牙膏具有抑制牙龈卟啉单胞菌的作用,抑菌环直径为20.5 mm;在二甲苯致小鼠耳廓肿胀的抗炎模型上,含0.2%甘草酸二钾的牙膏具有超过醋酸氟轻松软膏的效果。

关键词: 牙膏, 甘草酸二钾, 牙龈卟啉单胞菌, 最小抑菌浓度, 抑菌环, 抗炎

Abstract: Minimum inhibitory concentration of di-potassium glycyrrhizate on Porphyromonas gingivalis was tested and determined.Meanwhile,effectiveness of the toothpaste formulated with 0.2% di-potassium glycyrrhizate on Porphyromonas gingivalis as well as the influence on inflammation of pinnae of mice induced by xylene were examined.Experimental results show that di-potassium glycyrrhizate displays inhibitory effect on Porphyromonas gingivalis,and the minimum inhibitory concentration is 1.875 g/L.Average diameter of circle of scope of bacteriostasis of the toothpaste formulated with 0.2% di-potassium glycyrrhizate on Porphyromonas gingivalisis is 20.5 mm.Furthermore,test conducted at the anti-inflammatory model of the pinnae of mice induced by xylene shows that,the toothpaste formulated with 0.2% di-potassium glycyrrhizate is more effective than the positive control fluocinonide ointment.

Key words: toothpaste, di-potassium glycyrrhizate, Porphyromonas gingivalis, minimum inhibitory concentration, circle of scope of bacteriostasis, anti-inflammatory

中图分类号: 

  • TQ658.4+1