海藻糖脂在清洁体系中的泡沫和温和性研究

doi:10.3969/j.issn.2097-2806.2025.09.009

Abstract

Abstract:

The paper investigates the foaming and mildness properties of trehalolipids surfactant in rinse-off formulations, comparing it with the traditional nonionic surfactant alkyl-polyglycolide （APG）. Both single surfactant and their surfactant complexes are evaluated. And the results show that trehalolipids have significant advantages in reducing surface tension, improving foam performance, and enhancing mildness. For mildness evaluation, multiple methods are employed in the study, including in vitro cell toxicity, inflammatory markers, colorimetric index of mildness CIM, and in vivo method of human skin patch test. The results show that the addition of trehalolipids increases IC50 and reduces the release of inflammatory markers of the binary surfactant system. However, the incorporation of trehalolipids has some negative effects on the skin’s lipid barrier function. Skin patch test results indicate that the addition of trehalolipids improves the mildness of surfactant system, particularly in sulfate-free system. Overall, trehalolipids, as nonionic surfactants, presents great potential to replace traditional surfactants in rinse off formulations with enhanced mildness and foam performance.

Key words: trehalolipids, foam, mildness, colorimetric index of mildness CIM, zeta potential, skin patch test

CLC Number:

TQ423

Mei Chen, Yaoyao Wu, Dandan Xia, Xiaowei Chang, Guizhen Su, Chen Liu. Foam and mildness study of trehalolipid surfactant in rinse off formulations[J].China Surfactant Detergent & Cosmetics, 2025, 55(9): 1153-1162.

Figures/Tables 12

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References 33

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System	Composition	mass ratio	No.
SLES system	SLES∶CAPB	9∶9	S1
	SLES∶CAPB∶DG	6∶6∶6	S2
	SLES∶CAPB∶THL	6∶6∶6	S3
SMCT system	SMCT∶CAPB	9∶9	S4
	SMCT∶CAPB∶DG	6∶6∶6	S5
	SMCT∶CAPB∶THL	6∶6∶6	S6

Samples	Irritation Score （IS）
Samples	0.5 h	24 h	48 h	Total Score	Total Irritation Score （TIS）
S1	7^*	0	0	7^*	0.21^*
S2	6^*	0	0	6^*	0.18^*
S3	6^*	0	0	6^*	0.18^*
S4	5^*	2	0	7^*	0.21^*
S5	8^*	0	0	8^*	0.24^*
S6	5^*	0	0	5^*	0.15^*
Water	0	0	0	0	0

Foam and mildness study of trehalolipid surfactant in rinse off formulations

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