Abstract:

Toothpaste safety assessment has been conducted with the principle of industry self-discipline in China. To implement the Cosmetics Supervision and Administration Regulation （CSAR）, safety assessment of these products shall become part of the notification dossiers in future. Due to the uneven abilities of safety assessment and the uneven mastery of database, many companies have faced severe challenges when conducting safety assessment. Herein, the applications of domestic and foreign research data in toothpaste product safety assessment were introduced, such as China national standard “General requirements on raw materials of toothpastes”, data from food industry （food additives, condiments, new food raw materials） and traditional Chinese medicine, as well as findings and resources from cosmetic ingredient review （CIR）, scientific committee on consumer safety （SCCS）, joint FAO/WHO expert committee on food additives （JECFA）, etc. The applicability of toxicological test methods for related products in China was also discussed. Based on the current standards, rules, guidelines and assessment data or conclusions, combined with the characteristics of toothpastes, the applications of safety assessment database and toxicological test methods related to toothpastes were summarized, which could provide a useful reference for conducting safety assessment.

Key words: toothpaste, safety risk assessment, ingredient, food additive, cosmetic ingredient review （CIR）