Abstract:

In order to implement the Regulations on Supervision and Administration of Cosmetics （CSAR） and to improve the ingredient management and safety evaluation level of cosmetics, the National Medical Products Administration （NMPA） has established a system for submitting safety information of cosmetic ingredients, in combination with the drafting and revision of the supporting laws and regulations and the work of information system construction. Focused on this work, the authors analyze the general situation and related issues of the cosmetic ingredient management under the previous background of regulation and supervision, and introduce the general thoughts and arrangement under the new regulatory system of CSAR, so as to explain in detail the whole design and mechanisms of the safety information submission of cosmetic ingredients. Finally, based on practical feedback, the authors also discuss some key issues of common concern in the industry, such as the principle of composition identification and division, the concept of typical value/target value and range value of components, change of ingredient safety information, and the signature requirement of ingredient safety information documents. With these discussions, the work of safety information submission of cosmetic ingredients is reviewed and summarized, and some technical suggestions can also be provided.

Key words: cosmetics, ingredient, management, Regulations on Supervision and Administration of Cosmetics, safety information, safety evaluation