广藿香精油抗炎祛痘功效研究

doi:10.13218/j.cnki.csdc.2017.05.007

Abstract

Abstract: Chemical composition of the essential oil from Pogostemon cablin (Blanco) Benth.(EOP) was quantitatively analyzed by gas chromatography-mass spectrometry (GC-MS).The safe mass concentration of the EOP to Human Acute Mononuclear Cells (THP-1) was determined via cytotoxicity screening test.An inflammatory acne model was established by stimulating THP-1 with Propionibacterium acnes (P.acnes).Subsequently,the effect of the EOP on the expression of proinflammatory cytokine IL-1β was assessed.The anti-acne mechanism of the EOP was examined by qRT-PCR.Results show that at maximum safe mass concentration of 12.5 mg/L of the EOP,the influence on the activity of P.acnes is rather small and the secretion of IL-1β is significantly inhibited by a rate of 66.54%.The EOP also significantly reduces the mRNA level of Toll-like receptor 2 (TLR2) by 73.73%.Thereby,the EOP inhibits proinflammatory signal transduction and production of secondary inflammatory mediators.

Key words: cosmetic additive, essential oil from Pogostemon cablin, anti-acne, Propionibacterium acnes

CLC Number:

TQ658

WANG Yue, GUO Miao-miao, SHI Yan-qin, PAN Xian-hua, LU Yan-hua, CAO Ping. Anti-acne efficacy of essential oil from Pogostemon cablin (Blanco) Benth.[J].China Surfactant Detergent & Cosmetics, 2017, 47(5): 272-276.

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Anti-acne efficacy of essential oil from Pogostemon cablin (Blanco) Benth.

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