低分子量肝素改善小鼠皮肤微循环及光损伤修复的研究

doi:10.3969/j.issn.2097-2806.2026.09.009

Abstract

Abstract:

The non-anticoagulant activities of low molecular weight heparin （LMWH） have attracted increasing attention; however, its role in cutaneous protection remains insufficiently investigated. This study explored the effects of LMWH on improving microcirculation and repairing photodamage using cellular and animal models, while preliminarily elucidating its underlying mechanisms of action. In terms of microcirculation regulation, LMWH promotes cutaneous microcirculation by upregulating nitric oxide （NO） levels and accelerating the resolution of edema, thereby providing foundational support for tissue repair. At the cellular level, LMWH exerts a bidirectional regulatory effect on collagen synthesis: it significantly upregulates the expression of collagen IV and collagen XVII to strengthen basement membrane integrity, while simultaneously inhibiting UVB-induced expression of matrix metalloproteinase-9 （MMP-9） to suppress collagen degradation pathways. Animal models further confirm that LMWH effectively alleviates UVB-induced skin chapping, dryness, epidermal thickening, and collagen disruption. Collectively, LMWH improves cutaneous microcirculation, maintains collagen homeostasis, and protects against photodamage, highlighting its potential as an active ingredient in functional skincare formulations.

Key words: low molecular weight heparin, microcirculation, photodamage, MMP-9, collagen

CLC Number:

TQ658

Zhongliang Xu, Xiaoting Ren, Jinlong Liu, Xu Sun. Study on the improvement of cutaneous microcirculation and photodamage repair by low-molecular-weight heparin in mice[J].China Surfactant Detergent & Cosmetics, 2026, 56(9): 1207-1213.

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References 18

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组别	剂量/（mg/g）	n	左耳耳重/mg	右耳耳重/mg	耳肿胀值/mg
NC	0	10	25.71±2.25	35.58±3.64	9.87±1.32
PC	5	8	25.32±2.16	29.94±1.89	4.62±0.83^a
LMWH （低）	0.1	8	25.39±1.90	35.07±2.63	9.68±1.26^b
LMWH（中）	0.5	7	26.14±2.38	32.94±1.51	6.80±0.59^a
LMWH（高）	1	8	25.68±1.87	30.76±1.76	5.08±0.75^a

Study on the improvement of cutaneous microcirculation and photodamage repair by low-molecular-weight heparin in mice

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