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日用化学工业（中英文）

日用化学工业 ›› 2016, Vol. 46 ›› Issue (9): 514-518.doi: 10.13218/j.cnki.csdc.2016.09.006

• 开发与应用 • 上一篇    下一篇

神经酰胺ⅢB纳米脂质体的制备及功效评价

李霞1,田仁德1,许琦2,郭凤凤2,刘卫1,3   

  1. 1.华中科技大学 生命科学与技术学院,湖北 武汉 430074;
    2.武汉百思凯瑞纳米科技有限公司,湖北 武汉 430073;
    3.华中科技大学 国家纳米药物工程技术研究中心,湖北 武汉 430074
  • 出版日期:2016-09-22 发布日期:2019-04-18
  • 通讯作者: 刘卫,教授,博士生导师,电话:(027)87792147/68789309,E-mail:wliu@hust.edu.cn。
  • 作者简介:李霞(1990-),女,四川达州人,硕士研究生,电话:(027)68789309,E-mail:Shiny_xial@hust.edu.cn。
  • 基金资助:
    国家自然科学基金面上项目(31470968)

Preparation and efficacy evaluation of ceramide ⅢB nanoliposome

LI Xia1,TIAN Ren-de1,XU Qi2,GUO Feng-feng2,LIU Wei1,3   

  1. 1.College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan,Hubei 430074,China;
    2.Best-Carrier Nano Science and Technology Co.,Ltd.,Wuhan,Hubei 430073,China;
    3.National Engineering Research Center for Nanomedicine,Huazhong University of Science and Technology,Wuhan,Hubei 430074,China
  • Online:2016-09-22 Published:2019-04-18

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摘要： 采用高压匀质技术制备了神经酰胺ⅢB纳米脂质体,平均粒径为71.7 nm,PDI(多分散性系数)为0.214,Zeta电位为-23.3 mV,载药量和包封率分别为2.3%和95.9%。采用Franz扩散池法考察了其体外透皮性能,结果显示,其24 h体外皮肤累积透过量为709.23 μg/cm2,皮肤滞留量为75.07 μg/cm2。相同神经酰胺ⅢB质量分数的纳米脂质体霜剂与普通霜剂相比,前者24 h皮肤滞留量提高了近6倍。比较了连续给药40 d前后小鼠皮肤的水合能力,结果显示,神经酰胺ⅢB纳米脂质体组小鼠皮肤水合能力较对照组有明显提高,小鼠皮肤中总神经酰胺质量浓度高于对照组。

关键词: 化妆品添加剂, 神经酰胺ⅢB, 纳米脂质体, 功效评价

Abstract: Ceramide ⅢB nanoliposome was prepared by high pressure homogenization technique.Properties of the product were measured as particle size,71.7 nm;PDI,0.214;Zeta potential,-23.3 mV;rate of drug loading,2.3%;rate of encapsulation,95.9%.The in vitro skin permeation and retention tests were performed with Franz diffusion cell method.Results showed that the cumulative permeation and skin retention in 24 h was 709.23 and 75.07 μg/cm2,respectively.The skin retention of ceramide ⅢB nanoliposome cream product in 24 h was 6 times higher than that of conventional ceramide ⅢB cream product with the same mass fraction.The experiment was continued for 40 d on mouse skin and the results demonstrated that ceramide ⅢB nanoliposome exhibits a significant epidermal hydration capacity and total ceramides mass concentration as comparing with that of the control test group.

Key words: additives of cosmetics, ceramide ⅢB, nanoliposomeefficacy evaluation

中图分类号: 

  • TQ658