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日用化学工业（中英文）

日用化学工业 ›› 2015, Vol. 45 ›› Issue (5): 291-293.doi: 10.13218/j.cnki.csdc.2015.05.012

• 分析与检测 • 上一篇    下一篇

顶空气相色谱法测定制备原花青素脂质体残留有机溶剂的含量

杨爱玲1, 郭芳1, 赵鑫2, 王改香2, 林苗1   

  1. 1.东华大学 化学化工与生物工程学院 生态纺织教育部重点实验室,上海 201620;
    2.上海相宜本草化妆品股份有限公司,上海 200444
  • 出版日期:2015-05-22 发布日期:2019-04-02
  • 通讯作者: 林 苗,教授,博士,电话:(021)67792308,E-mail:linmiao@dhu.edu.cn。
  • 作者简介:杨爱玲(1989－),女,河南人,硕士研究生,E-mail:eilinyang2612@163.com。
       
  • 基金资助:
    上海相宜本草化妆品股份有限公司资助项目(原花青素脂质体的合成及产业化研究)

Determination of the residual solvent content for preparing proanthocyanidin lipsomes by head-space gas chromatography

YANG Ai-ling1, GUO Fang1, ZHAO Xin2, WANG Gai-xiang2, LIN Miao1   

  1. 1.Key Laboratory of Science and Technology of Eco-Textile,Ministry of Education, College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China;
    2.Shanghai Inoherb Cosmetics Co.,Ltd.,Shanghai 200444,China
  • Online:2015-05-22 Published:2019-04-02

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摘要： 确定了制备原花青素脂质体适宜的有机溶剂,采用氮吹法去除脂质体中残留的有机溶剂,以无水乙醇为内标,建立了顶空气相色谱法测定残留溶剂含量的分析方法。结果表明:在优化的色谱条件下,无水乙醚在0～25 mg/L的质量浓度范围内线性关系良好,相关系数R2=0.999 3;检出限为1.616 mg/L (S/N=3);加标回收率为91%～120%;相对标准偏差(RSD,n=6)小于4.72%。该法能快速、准确地检测制备原花青素脂质体残留有机溶剂的含量。

关键词: 护肤品添加剂, 原花青素, 顶空气相色谱法, 脂质体, 氮吹

Abstract: The suitable organic solvent used for preparing proanthocyanidin liposomes product was ascertained,and the residual organic solvent in the proanthocyanidin liposomes product was removed with nitrogen-blowing.Adopting anhydrous ethanol as the internal standard,a method for detection of residual solvent content with head-space gas chromatography was established.Under the optimal chromatographic conditions,the calibration curve of ether shows good linearity (R2=0.999 3) within the range of 0-25 mg/L,and the spiked recoveries are 91%-120% with the relative standard deviation (RSD) less than 4.72%.The limit of detection is 1.616 mg/L (S/N=3).This method can accurately determine the residual solvent content in the prepared proanthocyanidin liposomes product within a short period.

Key words: skin care cosmetic additives, proanthocyanidin, head-space gas chromatography, liposome, nitrogen-blowing

中图分类号: 

  • TQ658