王浆酸超分子微囊的制备及其性能研究

doi:10.3969/j.issn.2097-2806.2026.07.008

摘要/Abstract

摘要：

为解决王浆酸在实际应用中溶解性差的问题，本研究结合超分子技术与微囊包裹技术，制备了一种高载药量的王浆酸超分子微囊，该微囊由王浆酸、苦参碱、透明质酸钠与阿拉伯树胶组成，王浆酸最高载药量可达到20.5%。利用红外光谱、核磁共振氢谱、纳米粒度Zeta电位分析仪、透射电镜及扫描电镜等多种手段对其结构及形貌进行了系统表征，并针对制备的王浆酸超分子微囊开展了稳定性、渗透性及抗衰功效的研究。结果显示，王浆酸超分子微囊的形态呈球状，大小均一，平均粒径为（653.19±2.0）nm，多分散指数为0.408，Zeta电位为-14.93 mV，稳定性良好，能够显著提升王浆酸的经皮渗透性，且在促进 I 型胶原蛋白与弹性蛋白生成方面表现出更优异的效果。本研究为王浆酸在化妆品领域的实际应用奠定了重要基础。

关键词: 王浆酸, 苦参碱, 超分子微囊, 渗透, 抗衰

Abstract:

To address the poor solubility of 10-Hydroxy-2-decenoic acid（10-HDA）in practical applications, this study combined supramolecular technology with microcapsule encapsulation technology to prepare a 10-HDA supramolecular microcapsule with a high loading capacity. Composed of 10-HDA, matrine, sodium hyaluronate, and gum arabic, the optimized microcapsule achieves a maximum 10-HDA loading capacity of 20.5%. A variety of characterization methods, including Fourier Transform Infrared Spectroscopy（FT-IR）, Proton Nuclear Magnetic Resonance（¹H NMR）, Nanoparticle Size and Zeta Potential Analyzer, Transmission Electron Microscopy（TEM）, and Scanning Electron Microscopy（SEM）, were used to systematically characterize the formed supramolecular structure and morphology of the microcapsule. Additionally, the stability, permeability, and anti-aging efficacy of the prepared 10-HDA supramolecular microcapsule were conducted. The results show that the 10-HDA supramolecular microcapsule exhibits a well-defined, spherical core-shell morphology with a narrow size distribution. The microcapsules present an average particle size of（653.19 ± 2.0）nm, a polydispersity index（PDI）of 0.408, and a Zeta potential of -14.93 mV, indicating good stability. Moreover, the microencapsulation significantly improves the skin permeability of 10-HDA and shows superior efficacy in promoting the synthesis of type I collagen and elastin. This study lays an important theoretical and practical foundation for the broader application of 10-HDA in the cosmetics field.

Key words: 10-Hydroxy-2-decenoic acid, matrine, supramolecular microcapsules, permeability, anti-aging

中图分类号:

TQ658

苏蓓, 焦雅培, 王倩, 刘慧, 张辉, 刘菲. 王浆酸超分子微囊的制备及其性能研究[J]. 日用化学工业（中英文）, 2026, 56(7): 902-909.

Bei Su, Yapei Jiao, Qian Wang, Hui Liu, Hui Zhang, Fei Liu. Preparation and performance study of 10-HDA supramolecular microcapsules[J]. China Surfactant Detergent & Cosmetics, 2026, 56(7): 902-909.

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组别	w/%
组别	苦参碱	王浆酸	透明质酸钠	阿拉伯树胶
1号	15.8	11.8	1.2	71.2
2号	22.6	16.3	1.0	60.1
3号	27.4	20.5	0.8	51.3

原料名称	w/%
1, 3-丁二醇	5.0
甘油	5.0
透明质酸钠	0.1
王浆酸超分子微囊	1.7
馨鲜酮	0.5
1, 2-己二醇	0.5
水	To 100

原料名称	w/%
原料名称	样品A	样品B
1, 3-丁二醇	12	12
王浆酸	0	0.1
王浆酸超分子微囊	0.852	0
苦参碱	0	0.135
甘油	0.02	0.02
1, 2-戊二醇	0.005	0.005
透明质酸钠	0.01	0.02
卡波姆	0.3	0.3
对羟基苯乙酮	0.5	0.5
1, 2-己二醇	0.505	0.505
氨丁三醇	0.24	0.24
纯化水	To 100	To 100

样品	序号	化学位移	积分	归属
苦参碱	1	4.16~4.21	1	H-17a
	2	3.70~3.73	1	H-11
	1	2.90~3.02	1	H-17b
	2	2.71~2.78	2	H-2，H-10
	3	2.35~2.40	1	14-Ha
	4	2.27	1	14-Hb
	5	2.09	3	6-H、10,2-Ha
	6	1.92	4	3-Ha、5-H、12,4-He
	7	1.76	1	9-Ha
	8	1.45~1.63	9	3,8-2H、3,9-Hb、7-H、4,12-Ha
王浆酸	1	1.27	6	H-6、H-7、H-8
	2	1.40	4	H-5、H-9
	3	2.15	2	H-4
	4	3.37	2	H-10
	5	4.33	1	OH-1
	6	5.80	1	H-2
	7	6.58	1	H-3
	8	12.11	1	OH-10

时间/h	累积渗透量/μg
时间/h	样品A	样品B
2	2.49±0.13	0.17±0.01
8	4.92±0.36	0.24±0.15
24	8.13±0.29	1.30±0.09