基于超级微波消解-电感耦合等离子体质谱法分析儿童化妆品中的40种元素

doi:10.3969/j.issn.1001-1803.2023.04.014

摘要/Abstract

摘要：

为了解儿童化妆品中元素含量的情况，建立了超级微波消解-电感耦合等离子体质谱法测定儿童化妆品中40种元素的方法，方法学验证后，对75批样品进行了测定和检测结果分析评价。结果表明，该方法满足化妆品的检测要求，且方法简便、快速、准确、适用儿童化妆品中元素的测定。汞、铅、砷、镉元素检测结果均符合规定；镍、铬、钡三种元素，其中2批样品的钡元素测定结果分别为0.88和0.62 mg/kg，1批镍元素测定结果为6.71 mg/kg，其余样品三种元素的检测结果均小于0.5 mg/kg；钛元素测定结果为0.2~82.5 mg/kg；1批银元素的测结果为6.83 mg/kg；16种稀土元素均小于0.1 mg/kg，其余元素均小于0.3 mg/kg。建议在儿童化妆品中，对镍、铬、钡三种元素及其盐开展限度研究、对钛含量进行健康风险评估、对氰化银钾的检测方法进行完善，稀土元素和其余元素安全状况良好，安全风险较低。

关键词: 儿童化妆品, 超级微波消解, 电感耦合等离子体质谱, 元素

Abstract:

To investigate the content of elements in children’s cosmetics, a method for the determination of 40 elements in children’s cosmetics by super microwave digestion inductively coupled plasma mass spectrometry was established. After validation of the methodology, 75 batches of samples were determined and the results were analyzed. Results show that the methods meet the requirements of cosmetic testing with simple, rapid, accurate and can be used to the determination of elements in children’s cosmetics. The determination results of mercury, lead, arsenic and cadmium all conform to the standard. In the determination of nickel, chromium and barium, two batches of barium are 0.88 and 0.62 mg/kg, one batch of nickel is 6.71 mg/kg, and other samples are all less than 0.5 mg/kg. The determination results of titanium element range from 0.2 to 82.5 mg/kg. One batch of silver determination result is 6.83 mg/kg. The 16 rare earth elements are less than 0.1 mg/kg, and the other elements are less than 0.3 mg/kg. It is suggested that in children’s cosmetics, the limits of nickel, chromium, barium and their salts should be studied, the health risk of titanium content should be evaluated, and the detection method of silver potassium cyanide should be improved. Rare earth elements and other elements are in good safety condition with low safety risk.

Key words: children’s cosmetics, super microwave digestion, inductively coupled plasma mass spectrometry （ICP-MS）, element

中图分类号:

TQ658

潘小红, 殷帅, 刘玉玲, 黄海萍, 赵薇. 基于超级微波消解-电感耦合等离子体质谱法分析儿童化妆品中的40种元素[J]. 日用化学工业（中英文）, 2023, 53(4): 465-471.

Pan Xiaohong, Yin Shuai, Liu Yuling, Huang Haiping, Zhao Wei. Detection and analysis of 40 elements in children’s cosmetics based on super microwave digestion inductively coupled plasma mass spectrometry[J]. China Surfactant Detergent & Cosmetics, 2023, 53(4): 465-471.

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参考文献 16

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序号	名称	元素	序号	名称	元素	序号	名称	元素	序号	名称	元素
1	锂	⁶Li	11	砷	⁷⁵As	21	钡	¹³⁷Ba	31	钬	¹⁶⁵Ho
2	铍	⁹Be	12	铷	⁸⁵Rb	22	镧	¹³⁹La	32	铒	¹⁶⁶Er
3	铊	⁴⁷Ti	13	锶	⁸⁸Sr	23	铈	¹⁴⁰Ce	33	铥	¹⁶⁹Tm
4	钪	⁴⁵Sc	14	钇	⁸⁹Y	24	镨	¹⁴¹Pr	34	镱	¹⁷²Yb
5	钒	⁵¹V	15	钼	⁹⁵Mo	25	钕	¹⁴⁶Nd	35	镥	¹⁷⁵Lu
6	铬	⁵²Cr	16	银	¹⁰⁷Ag	26	钐	¹⁴⁷Sm	36	汞	²⁰²Hg
7	锰	⁵⁵Mn	17	镉	¹¹¹Cd	27	铕	¹⁵³Eu	37	铊	²⁰⁵Tl
8	钴	⁵⁹Co	18	铟	¹¹⁵In	28	钆	¹⁵⁷Gd	38	铅	²⁰⁸Pb
9	镍	⁶⁰Ni	19	锑	¹²³Sb	29	铽	¹⁵⁹Tb	39	铋	²⁰⁹Bi
10	铜	⁶³Cu	20	铯	¹³³Cs	30	镝	¹⁶³Dy	40	钍	²³²Th
内标				铑	¹⁰³Rh		铼	¹⁸⁶Re

序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）
1	0.255 0	12	0.083 7	23	0.234 1	34	0.054 3	45	0.080 0	56	0.055 7	67	0.061 1
2	0.090 0	13	0.072 5	24	0.097 7	35	6.714 2	46	0.212 5	57	0.032 9	68	0.044 8
3	0.206 1	14	0.157 3	25	0.046 4	36	0.109 4	47	0.061 5	58	0.038 1	69	0.122 1
4	0.366 7	15	0.078 9	26	0.066 7	37	0.042 7	48	0.039 0	59	0.088 1	70	0.015 2
5	0.107 2	16	0.094 7	27	0.256 3	38	0.101 5	49	0.046 7	60	0.033 2	71	0.063 2
6	0.105 7	17	0.053 2	28	0.072 0	39	0.062 5	50	0.102 7	61	0.033 8	72	0.000 0
7	0.222 5	18	0.095 7	29	0.101 4	40	0.063 0	51	0.073 8	62	0.044 2	73	0.044 0
8	0.067 4	19	0.151 9	30	0.091 5	41	0.064 8	52	0.047 7	63	0.055 1	74	0.008 7
9	0.103 4	20	0.262 8	31	0.562 6	42	0.046 7	53	0.042 6	64	0.083 7	75	0.014 3
10	0.076 2	21	0.318 0	32	0.466 8	43	0.180 7	54	0.068 4	65	0.022 9
11	0.076 1	22	0.274 6	33	0.069 3	44	0.055 5	55	0.044 8	66	0.028 1

序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）
1	0.005 4	4	0.001 0	7	0.008 4	10	0.002 7	13	0.000 0	16	0.000 0	19	0.004 8
2	0.002 7	5	0.005 0	8	0.004 5	11	0.006 7	14	6.827 9	17	0.003 2	20	0.003 9
3	0.001 4	6	0.006 7	9	0.001 0	12	0.003 4	15	0.001 3	18	0.002 5	21	0.005 2
22	0.000 9	30	0.002 5	38	0.002 7	46	0.002 8	54	0.006 1	62	0.000 6	70	0.000 4
23	0.002 1	31	0.001 0	39	0.005 3	47	0.001 4	55	0.000 4	63	0.000 6	71	0.000 4
24	0.000 5	32	0.000 3	40	0.000 7	48	0.000 9	56	0.000 5	64	0.000 2	72	0.001 0
25	0.002 8	33	0.002 3	41	0.002 4	49	0.000 3	57	0.000 7	65	0.000 7	73	0.000 4
26	0.003 4	34	0.001 4	42	0.001 9	50	0.000 6	58	0.000 6	66	0.000 6	74	0.000 4
27	0.002 9	35	0.001 1	43	0.008 5	51	0.000 4	59	0.000 5	67	0.000 3	75	0.000 4
28	0.000 5	36	0.000 6	44	0.000 6	52	0.005 8	60	0.000 4	68	0.000 5
29	0.005 6	37	0.000 8	45	0.000 8	53	0.000 6	61	0.000 6	69	0.000 2

序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）
1	0.070 6	12	0.036 5	23	0.041 6	34	0.042 1	45	0.016 4	56	0.059 0	67	0.014 8
2	0.051 1	13	0.019 0	24	0.039 3	35	0.139 8	46	0.000 0	57	0.053 5	68	0.031 0
3	0.122 4	14	5.521 8	25	0.000 0	36	0.000 0	47	0.016 0	58	0.014 3	69	0.014 2
4	0.023 3	15	0.023 0	26	0.040 1	37	0.000 0	48	0.017 8	59	0.047 4	70	0.014 7
5	0.023 4	16	0.000 0	27	0.039 7	38	0.000 0	49	0.016 1	60	0.014 8	71	0.000 0
6	0.025 0	17	0.086 5	28	0.054 1	39	0.000 0	50	0.000 0	61	0.015 3	72	0.000 0
7	0.080 5	18	0.000 0	29	0.055 2	40	0.015 3	51	0.042 3	62	0.015 3	73	0.000 0
8	0.038 4	19	0.000 0	30	0.017 2	41	0.014 8	52	0.000 0	63	0.061 2	74	0.046 3
9	0.061 1	20	0.039 3	31	0.037 8	42	0.015 6	53	0.000 0	64	0.027 4	75	0.000 0
10	0.000 0	21	0.021 4	32	0.000 0	43	0.116 6	54	0.000 0	65	0.015 8
11	0.000 0	22	0.000 0	33	0.069 6	44	0.049 0	55	0.028 9	66	0.000 0

序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）	序号	结果/ （mg/kg）
1	0.297 5	6	0.538 3	11	0.337 2	16	0.277 8	21	0.231 7	26	0.049 7	31	0.045 5
2	22.040 7	7	0.344 9	12	0.320 0	17	0.678 7	22	0.154 7	27	0.151 9	32	0.103 0
3	0.258 2	8	0.162 7	13	0.296 4	18	0.366 3	23	0.069 9	28	0.177 3	33	0.116 4
4	0.676 9	9	0.864 8	14	0.959 1	19	0.241 5	24	0.057 9	29	0.080 4	34	0.244 6
5	0.425 0	10	0.175 5	15	0.734 3	20	0.150 7	25	0.030 3	30	0.060 2	35	0.228 8
36	0.102 1	42	0.062 6	48	0.122 7	54	73.287 5	60	0.065 7	66	0.120 2	72	0.147 8
37	0.101 5	43	29.586 8	49	0.211 6	55	0.087 6	61	0.186 3	67	0.114 6	73	0.188 3
38	0.024 5	44	3.830 8	50	0.128 2	56	0.103 5	62	0.174 4	68	0.566 7	74	0.056 7
39	0.142 3	45	0.225 2	51	0.117 3	57	0.049 8	63	0.105 0	69	0.272 4	75	0.038 4
40	0.092 8	46	82.474 5	52	0.551 7	58	0.311 5	64	0.352 0	70	0.061 9
41	0.106 0	47	10.191 7	53	0.184 9	59	0.090 3	65	0.062 2	71	0.077 6