关键词: 抗敏修护组合物, 敏感性皮肤, 舒缓, 修护, 人体临床测试, 抗敏修护组合物, 敏感性皮肤, 舒缓, 修护, 人体临床测试

Abstract:

The soothing and repair functions of “Franicshield” on sensitive skin were studied. The anti-allergy ＆repair composition “Franicshield” was composed of ceramide, squalane and other skin lipid components to repair the skin barrier function; sodium hyaluronate and aloe leaf water were used to replenish water and moisturize the skin; natural active extracts such as Centella asiatica, Polygonum hydropiper and Inonotus obliquus were used to reduce skin inflammation and soothe skin. The anti-inflammatory effect and eye irritation were evaluated by TNF-a release induced by LPS from mouse macrophages （RAW264.7） and erythrocyte hemolysis test. Human clinical test was used for evaluation based on three dimensions: researcher evaluation, instrument measurement and subject self-assessment. The results showed that it had no significant effect on the activity of RAW264.7 mouse macrophages, and significantly inhibited the production of TNF-a inflammatory factor induced by LPS when the mass fraction of “Franicshield” was within 20%. The erythrocyte hemolysis test showed no irritation. After using “Franicshield” for 4 weeks, the subjects’ skin erythema, scaling, smoothness and roughness were improved, and the difference was statistically significant （P<0.05）. The water content of stratum corneum, TEWL value, red area change, lactic acid irritation and the relief rate of skin problems such as tingling, itching, tension and burning before and after use showed that “Franicshield” had good soothing and repair functions, and the difference was statistically significant （P<0.05）. No adverse skin reactions occurred during the 4-week test, indicating that it had good safety and was suitable for people with sensitive skin.

Key words: Franicshield, sensitive skin, soothing, repair, human clinical test, Franicshield, sensitive skin, soothing, repair, human clinical test