中药生发液对小鼠脱发的治疗作用研究

doi:10.3969/j.issn.1001-1803.2019.04.008

日用化学工业 ›› 2019, Vol. 49 ›› Issue (4): 244-247.doi: 10.3969/j.issn.1001-1803.2019.04.008

中药生发液对小鼠脱发的治疗作用研究

罗安玲,陈心馨,丁运文,热依沙·吾甫尔,郑有丽,丛峰松()

上海交通大学生命科学技术学院,上海 200240

收稿日期:2018-08-03 修回日期:2019-03-28 出版日期:2019-04-22 发布日期:2019-04-24
通讯作者: 丛峰松
作者简介:罗安玲（1994-）,女,侗族,贵州贵阳人,硕士研究生,电话：（021）34204097,E-mail：luoanling@163.com。

Study on therapeutic effect of traditional Chinese medicine hair restorer on hair loss in mice

LUO An-ling,CHEN Xin-xin,DING Yun-wen,REYISHA Wu-fuer,ZHENG You-li,CONG Feng-song()

School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China

Received:2018-08-03 Revised:2019-03-28 Online:2019-04-22 Published:2019-04-24
Contact: Feng-song CONG

摘要/Abstract

摘要：

通过给小鼠背部脱毛区涂抹中药生发液,研究了生发液对小鼠脱发的治疗作用。通过测量小鼠新生毛发的长度考察生发液对毛发再生速度的影响;利用皮肤HE染色切片研究生发液对毛囊形态结构和终毛/毳毛比值的影响;利用皮肤Masson染色切片研究生发液对胶原纤维排列的影响;利用Western Blot法研究生发液对皮肤内乳酸脱氢酶（Ldha）表达的影响。结果表明,与对照组比较,经中药生发液处理后的药物组毛发再生速度加快、毛囊数量增多、终毛/毳毛比值提高、胶原纤维排列更紧密有序、Ldha表达上调,说明中药生发液具有促进毛发生长的功效。

关键词: 脱发, 中药生发液, 毛囊, 终毛/毳毛比值, 乳酸脱氢酶

Abstract:

The therapeutic effect of traditional Chinese medicine hair restorer on hair loss in mice was studied by applying the hair restorer to the hair removal area on the back mice. The effect of hair restorer on hair regeneration rate was evaluated by measuring the newborn hair length on mice. The effect of hair restorer on the morphology of hair follicles and the terminal/vellus hair ratio was evaluated by observing the skin HE staining section. The effect of hair restorer on collagen fiber arrangement was evaluated by observing the skin Masson staining section. The effect of hair restorer on the expression of lactate dehydrogenase（Ldha）was detected by Western Blot. The results show that compared with the control group, the hair regeneration rate is accelerated, the number of hair follicles increases, the terminal/vellus hair ratio increases, collagen fibers arrange more closely and orderly, and the expression of Ldha is up-regulated in the treatment group, which indicate that the traditional Chinese medicine hair restorer has an efficacy of promoting hair growth.

Key words: hair loss, traditional Chinese medicine hair restorer, hair follicle, terminal/vellus hair ratio, lactate dehydrogenase

中图分类号:

TQ658.3

罗安玲,陈心馨,丁运文,热依沙·吾甫尔,郑有丽,丛峰松. 中药生发液对小鼠脱发的治疗作用研究[J]. 日用化学工业, 2019, 49(4): 244-247.

LUO An-ling,CHEN Xin-xin,DING Yun-wen,REYISHA Wu-fuer,ZHENG You-li,CONG Feng-song. Study on therapeutic effect of traditional Chinese medicine hair restorer on hair loss in mice[J]. China Surfactant Detergent & Cosmetics, 2019, 49(4): 244-247.

图/表 3

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中药生发液对小鼠脱发的治疗作用研究

Study on therapeutic effect of traditional Chinese medicine hair restorer on hair loss in mice

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