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日用化学工业（中英文）

日用化学工业 ›› 2018, Vol. 48 ›› Issue (11): 643-646.doi: 10.13218/j.cnki.csdc.2018.11.008

• 开发与应用 • 上一篇    下一篇

光甘草定对小鼠银屑病模型治疗作用的初步研究

洪婷1, 刘晓英2, 车飙2, 唐健2, 刘光荣2, 杜志云1   

  1. 1.广东工业大学,广东 广州 510006;
    2.无限极(中国)有限公司,广东 广州 510000
  • 收稿日期:2018-03-23 出版日期:2018-11-22 发布日期:2019-03-18
  • 通讯作者: 杜志云,教授,电话：13560456449,E-mail：zhiyundu@foxmail.com。
  • 作者简介:洪 婷(1996-),女,广东人,本科生,电话：15626176832,E-mail：695594973@qq.com。

Preliminary study on the therapeutic effect of glabridin on mouse psoriasis model

HONG Ting1, LIU Xiao-ying2, CHE Biao2, TANG Jian2, LIU Guang-rong2, DU Zhi-yun1   

  1. 1.Guangdong University of Technology,Guangzhou,Guangdong 510006,China;
    2.Infinitus (China) Company Ltd.,Guangzhou,Guangdong 510000,China
  • Received:2018-03-23 Online:2018-11-22 Published:2019-03-18

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摘要： 为探索光甘草定(PT)在治疗银屑病方面的作用,通过建立咪喹莫特乳剂(IMQ)诱导的小鼠银屑病耳廓肿胀模型和背部皮肤破损模型,再根据PT在人体皮肤用药标准设置不同含量进行给药。结果表明,在PT含量分别为30和15 g/kg时对小鼠耳廓红肿程度具有明显抑制效果,抑制率高达68.37%和56.98%。同时,对小鼠背部皮肤红肿、鳞屑、浸润增厚程度进行银屑病面积和严重程度指数(Psoriasis area severity index,PAIS)评分,绘制趋势线以观察各组小鼠皮损的变化情况,发现PT含量为30 g/kg时对小鼠皮损具有明显的抑制效果。

关键词: 护肤品, 光甘草定, 银屑病, 活性研究

Abstract: To explore the role of glabridin in the treatment of psoriasis,the model of auricle swelling and back skin damage induced by imiquimod emulsion (IMQ) in mouse were established,and then different doses of PT were given according to the standard of human skin administration.Results show that the PT contents of 30 and 15 g/kg have significant inhibitory effects on the degree of auricle swelling in mouse,and the inhibitory rate is 68.37% and 56.98% respectively.In the meantime,the psoriasis area severity index (PAIS) was scored on the back skin erythema,scale and thickness of the mouse.The trend line was drawn to observe the changes of skin lesions in each group.At 30 g/kg,PT has significant inhibitory effect on skin lesions of mouse.

Key words: skin care product, glabridin, psoriasis, activity research

中图分类号: 

  • TQ658.2