有害结局通路指南及毒性测试应用分析

doi:10.13218/j.cnki.csdc.2016.08.010

日用化学工业 ›› 2016, Vol. 46 ›› Issue (8): 473-478.doi: 10.13218/j.cnki.csdc.2016.08.010

有害结局通路指南及毒性测试应用分析

瞿小婷¹,程树军²,秦瑶³,柯逸晖²

1.国际人道对待动物协会,美国华盛顿哥伦比亚特区 20037;
2.广东出入境检验检疫局技术中心,广东广州 510623;
3.广州市华代生物科技有限公司,广东广州 510623

出版日期:2016-08-22 发布日期:2019-04-18
通讯作者: 程树军,博士,研究员,E-mail:chengsj@126.com。
作者简介:瞿小婷(1978-),女,湖北人,科技顾问,E-mail:tqu@hsi.org。
基金资助:
广东省科技计划资助项目(2015A030402005)

Adverse Outcome Pathways Guide and toxicity test applications

QU Xiao-ting¹,CHENG Shu-jun²,QIN Yao³,KE Yi-hui²

1.Humane Society International,Washington D.C. 20037,America;
2.Guangdong Inspection and Quarantine Technology Center, Guangzhou,Guangdong 510623,China;
3.Guangzhou Chn-Alt Biotech.Ltd.,Guangzhou,Guangdong 510623,China

Online:2016-08-22 Published:2019-04-18

摘要/Abstract

摘要： 综述了在21世纪毒性测试愿景与策略倡议下,以及现代科技发展和法规监管体系变革的背景下,有害结局通路(AOP)的提出和发展。重点介绍了AOP的概念和指南,AOP的基本组成、构建条件和信息共享,AOP的网络和评估;讨论了AOP在皮肤致敏和鱼类早期发育2个毒性终点的开发和应用情况,及其作为自上而下和从中间开始的2种AOP开发策略的实例;最后提出了AOP以现代科技发展为动力、毒性预测现代化为基础、推动法规监管模式变革为目标的发展策略。AOP指南也为替代动物测试方法的开发和检测技术创新提供了难得的机遇。

关键词: 有害结局通路, 替代方法, 毒性试验, 指南, 化学品

Abstract: The arising and development of Adverse Outcome Pathways (AOP) under the advocation of toxicity test vision and strategy in the 21st century as well as the pressure of regulation system changes and development of modern science and technology were reviewed.The concept and guide of AOP;the basic composition,structural conditions and information sharing of AOP as well as network and assessment of AOP were emphatically introduced.The development and application situation in two toxicity endpoints,the skin sensitization test and fish early-growth stage test were discussed as the practice instances of different AOP development strategy that is top-down approach and middle-out approach.Finally,it was concluded that the AOP relies on the development of modern science and technology as the driving force,toxicity prediction modernization as the basis,regulation mode change as the target.AOP guideline also provides an opportunity for the development of alternatives to animal testing method and testing technology innovation.

Key words: Adverse Outcome Pathways, alternative method, toxicity testing, guide, chemicals

中图分类号:

R114

瞿小婷,程树军,秦瑶,柯逸晖. 有害结局通路指南及毒性测试应用分析[J]. 日用化学工业, 2016, 46(8): 473-478.

QU Xiao-ting,CHENG Shu-jun,QIN Yao,KE Yi-hui. Adverse Outcome Pathways Guide and toxicity test applications[J]. China Surfactant Detergent & Cosmetics, 2016, 46(8): 473-478.

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有害结局通路指南及毒性测试应用分析

Adverse Outcome Pathways Guide and toxicity test applications

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