顶空-气相色谱法测定化妆品中甲基丙烯酸甲酯含量

doi:10.3969/j.issn.1001-1803.2020.08.012

Abstract

Abstract:

A new method was developed for the determination of methyl methacrylate （MMA） in cosmetics by headspace gas chromatography （HS-GC）. After being dissolved in acetone, the samples were determined by headspace gas chromatography-hydrogen flame ionization detector （HS-GC-FID） and quantified by external standard method. The LOD and LOQ of method were 6 and 20 mg/kg, respectively. There existed a good linearity for the MMA in the mass concentration range of 10~500 mg/L, with the correlation coefficient of 0.999 7. The average recoveries of MMA in the cosmetics （water-based, powder, emulsion, oiliness） were in the ranges of 98.2%~103.0% with their RSDs of 2.8%~7.6％. The optimized method is accurate, rapid and sensitive with simple pretreatment. It has been validated by eight testing institutions , and is suitable for the determination of MMA in cosmetics （water-based, powder, emulsion, oiliness）.

Key words: cosmetics, methyl methacrylate, headspace gas chromatography

CLC Number:

TQ658

ZHENG Guo-can,CHEN Jiang,WANG Jing,PENG Guang-yu. Determination of methyl methacrylate in cosmetics by headspace gas chromatography[J].China Surfactant Detergent & Cosmetics, 2020, 50(8): 576-580.

Figures/Tables 5

Fig. 1

Fig. 2

Tab. 1

Fig. 3

Tab. 2

References 20

[1]	Xiong Zengheng, Lin Yan, Lin Shaohua, et al. Optimization of graft polymerization conditions of methyl methacrylate onto pineapple leaf fibers and characterization of copolymers[J]. Biomass Chemical Engineering, 2017,51(6) : 11-18.
[2]	Shao Hongjuan, Tian Xiaohui, Sun Jinyu. Inclusion polymerization of β-cyclodextrin with methyl methacrylate for modifying natural rubber latex[J]. China Synthetic Rubber Industry, 2016,39(4) : 289-293.
[3]	Zhang Quan, Li Shen, Wang Qingqing, et al. Preparation and characterization of photodynamic antimicrobial poly （methyl mecthacrylate-co-methacrylic acid） electrospun nanofibrous membrane[J]. Journal of Textile Research, 2017,38(2) : 1-6. doi: 10.1177/004051756803800101
[4]	Luo Fusheng, Han Aijun, Yang Yi, et al. Preparation and application in cosmetic of PMMA-TiO₂ compounded micro-spheres[J]. China Surfactant Detergemt & Cosmetics, 2002,32(2) : 40-42.
[5]	Wang Chunhua, Chen Xi, Cao Shuyi. Toxic effect of MMA to the reproductive system of male rats[J]. Occup and Health, 2011,27(9) : 970-972.
[6]	Ouyang Guoshun, Hao Aigong, Fan Zhongna. et al. Chronic and epidemiological investigation of methyl methacrylate[J]. Chinese Journal of Industrial Hygiene and Occupational Diseases, 1990,8(1) : 7-11.
[7]	[ National Health Commission of the People’s Republic of China National food safety standard- general safety requirements for food contact materials and products: GB 4806.1—2016 [S]. Beijing: China Standard Press, 2016.
[8]	Tang Fangliang, Zhu Wen. Separation and determination of ethyl acrylate and methyl methacrylate in ambient air by gas chromatography[J]. Analysis and Testing Technology and Instruments, 2000,6(2) : 115-118.
[9]	Zhu Yanjun, Cheng Hesheng, Hu Yan, et al. Detecting content of trace MMA from composite materials of artificial skull with gas phase chromatography method[J]. New Chemical Materials, 2003,31(12) : 31-32.
[10]	Wu Caiyu, Zeng Chongyu. Gas chromatographic analysis of methyl methacrylate and methanol in its esterification mixture[J]. Chinese Journal of Chromtography, 1997,15(5) : 456-457.
[11]	Ou Yunfu, Yin Pinghe, Zhao Ling, et al. Analysis of deleterious emission in sculpturing organic glass using GC MS coupled with 3-step preconcentrator[J]. Chinese Journal of Analysis Laboratory, 2006,25(4) : 68-71.
[12]	Wang Yao, Yin Pinghe. GC-MS determination of organic pollutants in air of laser carving workshop[J]. PTCA (Part B: Chem. Anal.) , 2008,44(5) : 458-463.
[13]	National Health Commission of the People’s Republic of China. National food safety standard-food contact materials and products- determination of the migration of methyl methacrylate: GB 31604.29—2016 [S]. Beijing: China Standard Press, 2016.
[14]	Xu Huanbin, Zhang Dongmei, Zhao Yuanguang. The determination of the residual monomers in PMMA by using ultrasonic[J]. China Plastics Industry, 2014,42(2) : 104-106.
[15]	Zhao Hongyan, Cao Guofan, Zhang Xiaoling, et al. Head-Space-Gas chromatographic determination of amount of methyl methacrylate released from bone cement[J]. PTCA (Part B: Chem. Anal.) , 2009,45(6) : 707-709.
[16]	Administration of Quality Supervision, Inspection and Quarantine of the people’s Republic of China. Food contact materials and products- polymethylmethacrylate （PMMA） determination of methyl methacrylate gas chromatography: SN/T 3183—2012 [S]. Beijing: China Standard Press, 2012.
[17]	Wei Zheng, Huang Hong. Determination of residual monomer MMA in MMA-CR system by headspace sampling method[J]. Chemistry &Bioengineering, 2009,26(8) : 83-84, 94.
[18]	Ma Ming, Qing Jiang, Zhou Yun, et al. Head-space GC determination of migrated amount of methyl methacrylate from products of PMMA[J]. PTCA (Part B: Chem. Anal.) , 2013,49(12) : 1486-1488, 1492.
[19]	Hiroyuki O, Motoh M, Yoko K. Identification and quantitation of volatile organic compounds in poly （methyl methacrylate） kitchen utensils by headspace gas chromatography-mass spectrometry[J]. Journal of AOAC International. 2014,97(5) : 1452-1458. doi: 10.5740/jaoacint.12-425
[20]	Tiago F A, Sousa Marta C, Aniceto Célia G, et al. Vortex-assisted liquid-liquid micro-extraction and high-performance liquid chromatography for a higher sensitivity methyl methacrylate determination in biological matrices[J]. Biomedical Chromatography, 2014,28(5) : 680-685. doi: 10.1002/bmc.3089 pmid: 24265023

基质	添加水平/（mg·kg^-1）	平均回收率/%	RSD/%
	20	99.0	4.4
水基类	40	103.0	5.3
	200	101.9	4.0
	20	99.9	7.6
粉类	40	98.2	6.5
	200	101.3	5.4
	20	100.9	4.0
霜乳类	40	101.6	6.1
	200	101.8	4.9
	20	98.9	5.0
油类	40	99.8	2.8
	200	101.2	3.5

基质	添加水平/（mg·kg^-1）	平均回收率/%	RSD/%
	20	96.72	5.65
水基类	40	93.79	7.18
	200	98.47	4.54
	20	97.91	6.98
粉类	40	95.09	6.02
	200	97.51	5.28
	20	99.17	6.14
霜乳类	40	94.4	6.92
	200	95.77	7.16
	20	94.04	6.28
油类	40	92.84	7.12
	200	97.86	4.89

Determination of methyl methacrylate in cosmetics by headspace gas chromatography

RichHTML

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 5

References 20

Related Articles 15

Metrics

Comments

Recommended 10

[1]	Jingxuan Liu, Jianming Jin, Hua Wu. Botanical cosmetic ingredients （VII）Research and development of plant antifungal [J]. China Surfactant Detergent & Cosmetics, 2024, 54(3): 259-266.
[2]	Wu Bi, Xiaohong Pan, Xiaoqin Tu, Shuai Yin, Hui Sun. Analysis of the mechanism of anti-sensitive skin effect of cosmetic raw material Stephania tetrandra based on network pharmacology [J]. China Surfactant Detergent & Cosmetics, 2024, 54(3): 305-312.
[3]	Yaoyao Li. Study on the anti-aging and antioxidant effects of isosinensetin [J]. China Surfactant Detergent & Cosmetics, 2024, 54(3): 313-319.
[4]	Liyuan Zhang, Linqi Yan, Qiaoyuan Cheng, Lvye Qi, Rong Wang, Liuqian Huang. Determination of 14 kinds of α-hydroxy acids and hydroxy esters in cosmetics [J]. China Surfactant Detergent & Cosmetics, 2024, 54(3): 353-359.
[5]	Wei Xu, Po Zou, Changyu Li, Ming Yang, Yan Lu, Huiliang Li. Determination of 36 stimulants in cosmetics by ultra performance liquid chromatography-tandem mass spectrometry [J]. China Surfactant Detergent & Cosmetics, 2024, 54(3): 360-368.
[6]	Kangfu Zhou, Yixuan Zhi, Feifei Wang, Yazhuo Shang. New emulsion system and its application in cosmetics （VI）Microemulsion [J]. China Surfactant Detergent & Cosmetics, 2024, 54(2): 139-148.
[7]	Zhen Xie, Wei Huang, Jinsong Zhang, Shuhuai Chen, Linji Qu, Rong Kuang. Study on biomarkers of corneal injury in the evaluation of eye irritation of cosmetics [J]. China Surfactant Detergent & Cosmetics, 2024, 54(2): 161-167.
[8]	Xiaohong Pan, Ziqi Gao, Zhen Chen, Shuai Yin, Haiping Huang, Bin Hu. Discussion on the current situation of research and management on the stability of cosmetic products in China [J]. China Surfactant Detergent & Cosmetics, 2024, 54(2): 201-208.
[9]	Li Lu, Fang Fang, Youlong Feng, Ling Cao. Screening for illegal addition of sulfonamides in cosmetic products using ultra-performance liquid chromatographytriple quadrupoletandem mass spectrometry with precursor ion scanning [J]. China Surfactant Detergent & Cosmetics, 2024, 54(2): 216-223.
[10]	Ren Wang, Yuanyang Wu, Jia Qiao, Linqi Yan, Cen Chen, Liyuan Zhang. Study on phenoxyethanol content in children’s cosmetics on the mark and preliminary risk assessment [J]. China Surfactant Detergent & Cosmetics, 2024, 54(2): 224-230.
[11]	Yixiang Lu, Liting Wu, Jimin Jiang, Hailu Chen, Xuan Huang. Determination of tolnaftate and liranaftate in cosmetics by high performance liquid chromatography and verification by high performance liquid chromatography-tandem mass spectrometry [J]. China Surfactant Detergent & Cosmetics, 2024, 54(2): 231-238.
[12]	Liyuan Zhang, Qiaoyuan Cheng, Cen Chen, Zehua Li, Liuqian Huang, Lvye Qi. Determination of 3 kinds of α-hydroxy acids and their esters in cosmetics by high performance liquid chromatography [J]. China Surfactant Detergent & Cosmetics, 2024, 54(1): 102-106.
[13]	Linling Lu, Hui Lu, Chunyan Min, Yefei Qian. Determination of functional components of Glycyrrhizae, Ginseng and Scutellariae in facial masks by UHPLC-MS/MS [J]. China Surfactant Detergent & Cosmetics, 2024, 54(1): 107-113.
[14]	Xu Han, Jiajia Wu, Na Wu, Yazhuo Shang. New emulsion system and its application in cosmetics （V） Janus emulsion [J]. China Surfactant Detergent & Cosmetics, 2024, 54(1): 24-31.
[15]	Feng Liu, Yuanchang Deng, Guohong Ying, Xiaowei Wang. Establishment of duplex-PCR method for rapid detection of Pluralibacter gergoviae [J]. China Surfactant Detergent & Cosmetics, 2024, 54(1): 45-50.