超高效液相色谱-串联质谱法测定化妆品中27种磺胺类药物

doi:10.3969/j.issn.1001-1803.2023.01.014

Abstract

Abstract:

The study aims to establish an analytical method for determination of 27 illegally added sulfonamides in cosmetics by ultra-high performance liquid chromatography-tandem mass spectrometry. The samples were extracted by methanol，and separated on Thermo Hypersil GOLD column （100×2.1 mm，1.9 μm）, 0.1%（V/V）acetic acid aqueous solution and 0.1%（V/V）acetic acid acetonitrile solution were used as mobile phases with gradient elution. The quantitative analysis of 27 sulfonamides were operated in the electrospray ionization positive/negative mode using multiple reaction monitoring （MRM）. The correlation coefficients of linear calibration curves are greater than 0.99 in the corresponding mass concentration ranges of the 27 sulfonamides. The average recoveries of the 27 sulfonamides at three spiked levels range from 79.3% to 112.2% with the relative standard deviations of 1.4%-13.1%（n=6）. The LODS （S/N≥3） and LOQS（S/N≥10） are 2.3-97.6 μg/kg and 7.7-322.0 μg/kg, respectively. The results show that this method is simple, rapid, sensitive and reliable. It is suitable for qualitative and quantitative screening analysis of the 27 sulfonamides in cosmetics simultaneously.

Key words: ultra-high performance liquid chromatography-tandem mass spectrometry, sulfonamides, cosmetics, illegally added

CLC Number:

TQ658

He Liying, Jiang Fengbing. Determination of 27 sulfonamides in cosmetics by ultra-high performance liquid chromatography-tandem mass spectrometry[J].China Surfactant Detergent & Cosmetics, 2023, 53(1): 100-108.

Figures/Tables 7

Tab. 1

Tab. 2

MS parameters of the 27 sulfonamides"

序号	中文名称	英文名称	保留时间/min	电离方式	母离子（m/z）	锥孔电压/V	子离子（m/z）	碰撞能量/ V
1	磺胺胍	Sulfaguanidine	1.25	ESI⁺	215.1	89	108.2*/92.2	22/25
2	磺胺	Sulfanilamide	1.44	ESI⁺	173.1	32	156.0*/92.2	10/16
3	磺胺醋酰	Sulfacetamide	2.66	ESI^-	213.1	137	195.0*/171.0	18/19
4	磺胺二甲异嘧啶	Sulfisomidine	3.01	ESI⁺	279.1	132	124.2*/185.9	21/15
5	磺胺嘧啶	Sulfadiazine	3.31	ESI⁺	251.1	103	156.0*/92.2	15/26
6	磺胺噻唑	Sulfathiazole	4.21	ESI⁺	256.0	110	156.0*/92.2	15/25
7	磺胺吡啶	Sulfapyridine	4.31	ESI⁺	250.1	141	156.0*/184.0	16/17
8	二甲氧苄啶	Diaveridine	4.38	ESI⁺	261.1	175	245.0*/123.1	23/26
9	磺胺甲基嘧啶	Sulfapyridine	4.63	ESI⁺	265.1	99	172.0*/156.0	15/16
10	甲氧苄啶	Trimethoprim	5.15	ESI⁺	291.1	187	230.0*/261.0	23/25
11	磺胺二甲噁唑	Sulfamoxole	5.76	ESI⁺	268.1	122	156.0*/92.2	15/26
12	磺胺二甲嘧啶	Sulfamethazine	5.87	ESI⁺	279.1	154	186.0*/124.1	16/24
13	磺胺对甲氧嘧啶	Sulfameter	6.01	ESI⁺	281.1	133	156.0*/108.2	16/25
14	琥珀酰磺胺噻唑	Succinylsulfathiazole	6.07	ESI^-	354.0	151	253.9*/98.1	13/23
15	磺胺甲噻二唑	Sulfamethizole	6.21	ESI^-	269.0	139	196.0*/187.9	21/17
16	磺胺甲氧哒嗪	Sulfamethoxypyridazine	6.36	ESI⁺	281.1	154	156.0*/92.2	16/28
17	磺胺间甲氧嘧啶	Sulfamonomethoxine	7.50	ESI^-	279.1	192	132.1*/183.0	30/22
18	磺胺氯哒嗪	Sulfachloropyridazine	7.52	ESI^-	283.0	166	155.9*/128.0	26/28
19	磺胺邻二甲氧嘧啶	Sulfadoxine	8.33	ESI⁺	311.1	156	156.0*/108.1	17/25
20	磺胺甲基异噁唑	Sulfamethoxazole	8.50	ESI^-	252.1	117	156.0*/92.1	15/26
21	磺胺二甲异噁唑	Sulfisoxazole	9.36	ESI^-	266.1	134	171.0*/238.9	18/17
22	磺胺苯甲酰	Sulfabenzamide	10.14	ESI^-	275.1	179	156.0*/108.1	26/24
23	磺胺氯吡嗪	Sulfachloropyrazine	10.77	ESI^-	283.0	153	107.1*/156.0	19/24
24	磺胺间二甲氧嘧啶	Sulfadimethoxine	11.37	ESI⁺	311.1	154	156.0*/92.2	20/32
25	磺胺苯吡唑	Sulfaphenazole	11.61	ESI^-	313.1	181	156.0*/92.1	26/35
26	磺胺喹噁啉	Sulfaquinoxaline	11.73	ESI⁺	301.1	126	156.0*/92.2	15/27
27	磺胺硝苯	Sulfanitran	17.24	ESI^-	334.0	222	136.0*/270.0	29/23

Tab. 2

Fig. 1

Tab. 3

Linear equations, correlation coefficients, LODs and LOQs of the 27 sulfonamides"

序号	组分名称	线性范围/ （ng/mL）	线性方程	相关系数r	检出质量浓度/（ng/mL）	定量质量浓度/（ng/mL）	检出限/ （μg/kg）	定量限/ （μg/kg）
1	磺胺胍	2~200	Y=3 566X+3 358	0.999 7	0.8	2.0	30.3	100.0
2	磺胺	20~2 000	Y=1 045X-22 950	0.998 1	1.8	6.0	90.3	297.9
3	磺胺醋酰	20~2 000	Y=590.5X+10 910	0.999 2	2.0	6.4	97.6	322.0
4	磺胺二甲异嘧啶	2~200	Y=21 180X-17 970	0.999 0	0.1	0.2	2.8	9.2
5	磺胺嘧啶	2~200	Y=10 860X-8 631	0.998 5	0.6	2.0	30.1	99.3
6	磺胺噻唑	4~200	Y=16 350X-22 160	0.999 7	0.9	3.1	46.4	153.2
7	磺胺吡啶	2~200	Y=8 358X+10 270	0.999 6	0.1	0.3	4.1	13.4
8	二甲氧苄啶	2~200	Y=26 260X-7 432	0.999 6	0.1	0.2	3.0	10.0
9	磺胺甲基嘧啶	4~200	Y=7 447X-2 696	0.999 6	0.8	2.6	38.9	128.4
10	甲氧苄啶	2~200	Y=12 700X-9 021	0.999 3	0.1	0.2	2.8	9.3
11	磺胺二甲噁唑	2~200	Y=11 370X-8 466	0.999 2	0.0	0.2	2.3	7.7
12	磺胺二甲嘧啶	2~200	Y=17 580X-3 493	0.999 6	0.1	0.3	4.6	15.1
13	磺胺对甲氧嘧啶	2~200	Y=5 260X-5 553	0.998 7	0.6	2.0	30.3	100.0
14	琥珀酰磺胺噻唑	2~200	Y=1 798X-2 887	0.998 2	0.6	2.1	31.8	105.0
15	磺胺甲噻二唑	4~200	Y=2 114X-1 952	0.998 3	0.8	2.5	37.9	125.0
16	磺胺甲氧哒嗪	2~200	Y=8 996X-4 785	0.999 6	0.6	1.9	29.4	97.0
17	磺胺间甲氧嘧啶	20~2 000	Y=273.8X+20 920	0.995 2	1.6	5.3	79.6	262.6
18	磺胺氯哒嗪	20~2 000	Y=79.91X+4 360	0.997 9	1.7	5.5	83.8	276.5
19	磺胺邻二甲氧嘧啶	2~200	Y=15 010X+8 045	0.999 5	0.1	0.2	3.1	10.2
20	磺胺甲基异噁唑	2~200	Y=2 781X-6 704	0.998 1	0.6	1.9	28.2	93.0
21	磺胺二甲异噁唑	2~200	Y=1 995X+1 836	0.999 1	0.6	2.1	31.8	105.0
22	磺胺苯甲酰	20~2 000	Y=417.5X+15 890	0.998 7	0.5	1.6	24.8	81.8
23	磺胺氯吡嗪	20~2 000	Y=108.4X+6 442	0.997 0	1.4	4.7	71.0	234.3
24	磺胺间二甲氧嘧啶	2~200	Y=15 210X+3 081	0.999 1	0.1	0.3	4.5	14.8
25	磺胺苯吡唑	2~200	Y=2 743X+5 084	0.999 4	0.7	2.2	34.1	112.4
26	磺胺喹噁啉	2~200	Y=10 490X-5 149	0.999 2	0.1	0.2	2.8	9.3
27	磺胺硝苯	4~200	Y=1 014X+5 827	0.997 2	0.7	2.4	36.4	120.0

Tab. 3

Tab. 4

Recoveries and precisions in different matrices of the 27 sulfonamides at low spiked level"

序号	组分名称	霜膏		散粉		唇膏		水剂		香波
序号	组分名称	回收率/%	RSD/%	回收率/%	RSD/%	回收率/%	RSD/%	回收率/%	RSD/%	回收率/%	RSD/%
1	磺胺胍	111.0	7.5	105.1	6.0	105.5	12.2	107.2	6.1	107.7	12.4
2	磺胺	95.0	7.2	106.7	6.1	90.7	5.1	108.9	6.2	92.5	5.2
3	磺胺醋酰	102.4	7.6	105.1	6.6	102.7	5.9	107.2	6.7	104.8	6.0
4	磺胺二甲异嘧啶	106.0	8.4	107.5	4.5	106.0	7.6	109.7	4.6	108.2	7.8
5	磺胺嘧啶	103.6	9.0	99.5	5.5	94.4	5.5	101.5	5.6	96.3	5.6
6	磺胺噻唑	104.3	9.3	82.3	11.6	90.5	5.6	84.0	11.8	92.3	5.7
7	磺胺吡啶	108.2	6.5	106.5	11.2	105.0	10.8	108.7	11.4	107.1	11.0
8	二甲氧苄啶	112.2	9.8	101.6	4.1	102.9	1.6	103.7	4.2	105.0	1.6
9	磺胺甲基嘧啶	107.6	8.5	99.4	10.2	102.2	6.9	101.4	10.4	104.3	7.0
10	甲氧苄啶	103.6	7.9	102.3	5.6	105.2	6.8	104.4	5.7	107.3	6.9
11	磺胺二甲噁唑	98.1	10.0	102.9	7.0	93.8	6.8	105.0	7.1	95.7	6.9
12	磺胺二甲嘧啶	101.9	7.1	89.9	6.6	90.5	9.3	91.7	6.7	92.3	9.5
13	磺胺对甲氧嘧啶	103.7	9.1	103.2	8.1	93.8	10.6	105.3	8.3	95.7	10.8
14	琥珀酰磺胺噻唑	84.3	9.0	79.3	6.7	86.5	3.8	80.9	6.8	88.3	3.9
15	磺胺甲噻二唑	93.6	11.5	81.2	10.0	99.1	13.4	82.9	10.2	101.1	13.1
16	磺胺甲氧哒嗪	107.7	6.8	106.1	10.6	85.8	11.4	108.3	10.8	87.5	11.6
17	磺胺间甲氧嘧啶	105.2	4.3	105.9	4.2	105.4	6.1	108.1	4.3	107.6	6.2
18	磺胺氯哒嗪	102.2	5.1	104.3	8.6	102.9	5.8	106.4	8.8	105.0	5.9
19	磺胺邻二甲氧嘧啶	103.8	7.8	103.5	10.7	97.6	6.5	105.6	10.9	99.6	6.6
20	磺胺甲基异噁唑	93.7	10.0	83.4	12.1	86.2	9.8	85.1	12.3	88.0	10.0
21	磺胺二甲异噁唑	96.0	9.9	90.9	9.1	106.9	13.2	92.8	9.3	109.1	12.5
22	磺胺苯甲酰	105.4	5.6	99.0	6.2	104.9	6.0	101.0	6.3	107.0	6.1
23	磺胺氯吡嗪	104.8	6.1	106.2	4.8	103.0	7.2	108.4	4.9	105.1	7.3
24	磺胺间二甲氧嘧啶	99.2	11.2	94.6	8.6	106.1	8.2	96.5	8.8	108.3	8.4
25	磺胺苯吡唑	104.5	10.0	100.1	11.6	107.1	12.7	102.1	11.8	109.3	11.0
26	磺胺喹噁啉	101.2	12.0	92.8	9.0	104.2	9.1	94.7	9.2	106.3	9.3
27	磺胺硝苯	95.2	9.7	97.2	8.5	100.2	7.6	99.2	8.7	102.2	7.8

Tab. 4

Tab. 5

Recoveries and precisions in different matrices of the 27 sulfonamides at medium spiked level"

序号	组分名称	霜膏		散粉		唇膏		水剂		香波
序号	组分名称	回收率/%	RSD/%	回收率/%	RSD/%	回收率/%	RSD/%	回收率/%	RSD/%	回收率/%	RSD/%
1	磺胺胍	101.8	5.3	107.4	5.1	106.9	4.8	99.6	6.1	106.9	11.4
2	磺胺	108.6	4.2	92.2	5.7	92.0	6.0	96.9	6.2	107.7	5.2
3	磺胺醋酰	94.0	7.4	105.1	2.2	108.1	2.9	98.2	6.7	108.8	6.0
4	磺胺二甲异嘧啶	92.0	7.2	108.8	5.9	108.6	6.9	99.9	4.6	108.9	7.8
5	磺胺嘧啶	93.5	5.5	106.3	4.0	107.1	2.8	99.0	5.6	109.7	5.6
6	磺胺噻唑	92.1	5.8	83.8	5.7	84.1	13.0	85.3	11.8	80.7	5.7
7	磺胺吡啶	88.3	5.7	95.1	2.3	95.6	4.3	100.4	11.4	109.3	9.0
8	二甲氧苄啶	99.4	6.1	107.8	3.1	109.1	1.9	100.8	4.2	109.4	1.6
9	磺胺甲基嘧啶	107.4	7.2	107.1	3.6	105.3	6.9	98.6	10.4	108.8	7.0
10	甲氧苄啶	90.2	6.4	103.6	3.3	108.8	3.9	100.4	5.7	108.4	6.9
11	磺胺二甲噁唑	94.2	8.9	102.1	5.7	104.0	6.7	99.5	7.1	107.2	6.9
12	磺胺二甲嘧啶	93.9	8.5	100.1	3.1	98.7	4.0	96.9	6.7	104.3	9.5
13	磺胺对甲氧嘧啶	88.8	8.3	110.8	6.5	108.6	3.4	103.7	8.3	111.4	8.8
14	琥珀酰磺胺噻唑	104.4	6.4	108.1	7.3	87.8	11.9	96.2	6.8	82.0	3.9
15	磺胺甲噻二唑	90.2	6.8	101.5	4.6	101.4	8.1	103.1	10.2	96.8	12.7
16	磺胺甲氧哒嗪	92.7	5.4	108.2	5.2	105.2	7.6	106.4	10.8	105.1	11.6
17	磺胺间甲氧嘧啶	106.9	5.6	109.0	5.6	107.8	5.4	101.8	4.3	109.4	6.2
18	磺胺氯哒嗪	97.2	5.2	100.4	6.8	106.1	5.2	98.4	8.8	102.2	5.9
19	磺胺邻二甲氧嘧啶	89.9	7.2	109.0	3.0	107.4	9.1	103.5	10.9	108.4	6.6
20	磺胺甲基异噁唑	101.0	7.9	99.2	10.8	93.5	6.7	97.0	12.3	89.9	10.2
21	磺胺二甲异噁唑	97.7	7.2	108.5	3.4	108.7	6.0	99.4	9.3	107.9	11.5
22	磺胺苯甲酰	102.7	7.3	104.9	7.2	108.3	6.7	103.0	6.3	104.4	6.1
23	磺胺氯吡嗪	97.1	6.4	107.3	6.9	106.2	7.0	102.9	4.9	107.2	7.3
24	磺胺间二甲氧嘧啶	96.6	7.7	105.4	5.2	105.9	5.3	101.3	8.8	102.4	8.4
25	磺胺苯吡唑	106.7	8.2	109.0	4.6	107.0	6.4	102.0	11.8	109.6	11.0
26	磺胺喹噁啉	88.1	8.7	108.0	5.3	104.5	7.4	99.2	9.2	101.5	6.3
27	磺胺硝苯	99.8	7.2	98.8	6.2	99.4	7.5	101.4	8.7	108.1	7.2

Tab. 5

Tab. 6

Recoveries and precisions in different matrices of the 27 sulfonamides at high spiked level"

序号	组分名称	霜膏		散粉		唇膏		水剂		香波
序号	组分名称	回收率/%	RSD/%	回收率/%	RSD/%	回收率/%	RSD/%	回收率/%	RSD/%	回收率/%	RSD/%
1	磺胺胍	102.7	3.9	107.5	5.4	106.6	7.0	97.4	6.8	105.9	7.3
2	磺胺	98.4	5.7	100.7	6.7	107.9	6.0	93.4	2.0	92.2	4.7
3	磺胺醋酰	97.7	4.5	99.9	6.6	101.4	7.0	108.1	4.8	102.6	6.1
4	磺胺二甲异嘧啶	99.1	6.7	97.7	5.7	108.2	6.4	103.9	6.2	102.5	7.1
5	磺胺嘧啶	94.8	5.8	92.2	6.7	107.4	5.2	98.0	4.6	92.4	6.6
6	磺胺噻唑	95.7	6.0	91.5	3.9	91.3	3.8	91.4	4.9	90.7	4.2
7	磺胺吡啶	100.1	4.9	95.2	6.7	108.9	6.8	98.1	5.8	101.6	5.7
8	二甲氧苄啶	101.6	5.4	97.7	6.5	103.3	7.3	101.9	7.0	100.1	5.4
9	磺胺甲基嘧啶	97.4	6.0	93.7	5.5	99.6	4.8	104.8	4.2	96.6	7.1
10	甲氧苄啶	102.1	5.1	101.9	7.2	105.7	4.3	103.7	6.9	106.9	3.6
11	磺胺二甲噁唑	97.5	4.3	94.7	3.2	108.4	1.4	107.0	6.0	93.7	6.9
12	磺胺二甲嘧啶	98.3	5.6	92.6	6.9	106.0	3.0	101.7	6.5	92.3	7.2
13	磺胺对甲氧嘧啶	102.7	3.2	93.1	6.6	102.4	4.7	99.9	4.9	96.7	6.3
14	琥珀酰磺胺噻唑	98.2	4.1	91.0	5.1	94.8	4.0	91.4	6.3	91.0	6.4
15	磺胺甲噻二唑	98.2	6.0	94.3	5.7	107.6	3.7	108.4	6.4	96.7	2.2
16	磺胺甲氧哒嗪	97.4	5.3	93.4	6.5	109.2	4.5	96.9	4.7	92.5	5.7
17	磺胺间甲氧嘧啶	102.6	3.7	109.3	4.7	99.7	3.4	106.4	7.0	108.6	5.5
18	磺胺氯哒嗪	102.0	2.4	107.4	6.9	105.9	5.5	103.3	4.0	107.5	6.8
19	磺胺邻二甲氧嘧啶	99.5	6.3	100.4	5.9	104.5	6.0	105.8	7.1	105.1	5.0
20	磺胺甲基异噁唑	95.7	6.7	91.1	6.6	99.9	4.7	103.0	5.5	93.4	5.2
21	磺胺二甲异噁唑	99.2	6.2	106.8	7.3	107.4	5.9	107.6	6.3	108.0	3.8
22	磺胺苯甲酰	105.4	5.2	107.6	6.1	106.0	6.6	97.7	7.2	105.0	5.9
23	磺胺氯吡嗪	108.7	3.9	109.7	4.3	101.4	6.5	102.8	2.8	99.2	5.6
24	磺胺间二甲氧嘧啶	95.1	6.4	93.8	6.7	108.3	4.3	101.6	2.5	101.0	7.2
25	磺胺苯吡唑	102.7	4.4	105.7	6.8	104.2	4.1	106.6	6.8	104.4	6.7
26	磺胺喹噁啉	98.1	5.9	91.5	5.3	92.9	5.6	108.0	7.2	100.7	3.8
27	磺胺硝苯	102.3	5.6	104.9	6.1	106.9	4.9	105.9	6.6	104.9	7.1

Tab. 6

References 19

[1]	Iimedia Research. China cosmetics industry research and development report in 2021 [EB/OL]. (2021-05-31) [2022-01-21]. https://www.iimedia.cn/c400/78987.html.
[2]	Xu H M, Cai H W, Li T Y, et al. Progress in sulfonamide hypersensitivity and cross-hypersensitivity[J]. Chin J Pharmacol Toxicol, 2012, 26 (6) : 897-902.
[3]	Dmitrienko S G, Kochuk E V, Apyari V V, et al. Recent advances in sample preparation techniques and methods of sulfonamides detection: A review[J]. Anal Chim Acta, 2014, 850: 6. doi: 10.1016/j.aca.2014.08.023
[4]	Ren D D, Xie Y F, Li S H, et al. Determination of 17 kinds of sulfonamide residues in livestock and poultry meat by ultra performance liquid chromatography-tandem mass spectrometry[J]. Journal of Food Safety and Quality, 2018, 9 (4) : 858-863.
[5]	Jiang W, Belogazova N, Wang Z, et al. Development of a multiplex flow-through immunoaffinity chromatography test for the on-site screening of 14 sulfonamide and 13 quinolone residues in milk[J]. Biosens Bioelectron, 2015, 66: 124-128. doi: 10.1016/j.bios.2014.11.004 pmid: 25460892
[6]	Wang X L, Wu Y N. Application of chromatography in food safety analysis[M]. Beijing: China Light Industry Press, 2005: 104-105.
[7]	Committee of Experts on Cosmetic Standards of the State Food and Drug Administration.Safety and Technical Standards for Cosmetics (2015 Edition) [S]. Beijing: People’s Medical Publishing House, 2017: 5-71.
[8]	Cao H, Wang H, Liu Y Q, et al. Determination of 12 kinds of sulfonamide residues in cosmetics by LC-MS-MS method[J]. China Surfactant Detergent & Cosmetics, 2010, 40 (4) : 308-310.
[9]	Qian Y F, Jia C P. Determination of 21 sulfonamides illegally added into cosmetics by HPLC-DAD[J]. Guangzhou Chemical Industry, 2016, 44 (10) : 150-152.
[10]	Chung H, Lee J, Chung Y, et al. Analysis of sulfonamide and quinolone antibiotic residues in Korean milk using microbial assays and high performance liquid chromatography[J]. Food Chem, 2009, 113 (1) : 297-301. doi: 10.1016/j.foodchem.2008.07.021
[11]	Díez R, Sarabia L, Ortiz M. Rapid determination of sulfonamides in milk samples using fluorescence spectroscopy and class modeling with n-way partial least squares[J]. Anal Chim Acta, 2007, 585 (2) : 350-360. pmid: 17386685
[12]	Conzuelo F, Campuzano S, Gamella M, et al. Integrated disposable electrochemical immunosensors for the simultaneous determination of sulfonamide and tetracycline antibiotics residues in milk[J]. Biosens Bioelectron, 2013, 50 (15) : 100-105. doi: 10.1016/j.bios.2013.06.019
[13]	General Administration of Quality Supervision, Inspection and Quarantine of the People’s Republic of China,Standardization Administration. Determination of 21 sulfonamides in cosmetics by high performance liquid chromatography method: GB/T 24800.6—2009 [S]. Beijing: China Quality and Standards Publishing and Media Co., Ltd., 2010.
[14]	Li J, Wang P, Zheng H H. Simultaneous determination of nine sulfonamides in cosmetic by high performance liquid chromatography[J]. Chinese Journal of Health Laboratory Technology, 2009, 19 (11) : 2526-2527.
[15]	Yang Y W, Zhu Y. Simultaneous determination of 11 sulfonamides in cosmetic by high performance liquid chromatography[J]. Chinese Journal of Health Laboratory Technology, 2006, 16 (11) : 1343-1344.
[16]	Shen S L, Lu H J, Tao S, et al. Determination of fourteen sulfonamides in poultice cosmetic by high performance liquid chromatography coupled with ultrasonic-assisted extraction[J]. Chinese Journal of Analysis Laboratory, 2013, 32 (10) : 121-124.
[17]	Luo H T, Huang X L, Wu H Q, et al. Simultaneous rapid determination of 81 glucocorticoids in cosmetics by dispersive solid phase extraction and liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2017, 35 (8) : 816-825. doi: 10.3724/SP.J.1123.2017.04005
[18]	Zhang Y Z, Hu J C, Zhou F, et al. High-performance liquid chromatography-tandem mass spectrometry for the determination of 21 sulfonamide residues in Eriocheir sinensis[J]. Journal of Zhejiang Ocean University (Natural Science), 2009, 28 (1) : 36-42.
[19]	Ma Q, Wang C, Wang X, et al. Simultaneous determination of 22 sulfonamides in cosmetics by ultra performance liquid chromatography tandem mass spectrometry[J]. Chinese Journal of Analytical Chemistry, 2008, 36 (12) : 1683-1689.

Determination of 27 sulfonamides in cosmetics by ultra-high performance liquid chromatography-tandem mass spectrometry

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洗脱时间/min	φ（流动相A）/%	φ（流动相B）/%
0	94	6
5	84	16
8	78	22
14	75	25
18	45	55
19	45	55
20	94	6
23	94	6