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China Surfactant Detergent & Cosmetics ›› 2021, Vol. 51 ›› Issue (4): 356-362.doi: 10.3969/j.issn.1001-1803.2021.04.014

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Laboratory preparation of lipoic acid esters and their application prospect in cosmetics

SONG Jing-jiu1(),GUO Xiao-dan1,WANG Dong1,ZHU Jun1,2()   

  1. 1. College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China
    2. Key Laboratory of Cosmetics, China National Light Industry, Beijing 100048, China
  • Received:2020-05-30 Revised:2021-03-30 Online:2021-04-22 Published:2021-04-27
  • Contact: Jun ZHU E-mail:songjingjiu_btbu@163.com;zhujun@btbu.edu.cn

Abstract:

Lipoic acid is both a drug and a multi-functional antioxidant. The cosmetics using lipoic acid as raw material have excellent performance, but they also have many problems, such as being not easy to preserve and strong irritation. The instability and poor water solubility of lipoic acid also bring inconvenience to professionals in research. The combination of lipoic acid with other functional materials as lipoic acid esters can improve the deficiency of lipoic acid and enhance the efficacy. The esterification reaction is one of the most classic reactions in the chemical world. There are many catalytic methods, and each method has unique advantages and disadvantages. However, according to statistics, only a few of them were most frequently used, and many excellent esterification methods had often been ignored. The laboratory preparation methods of lipoic acid esters were summarized from the aspects of chemical catalysis and biological enzyme catalysis. The advantages and disadvantages of each method were analyzed, and the application prospect of lipoic acid esters in cosmetics was discussed.

Key words: lipoic acid ester, esterification reaction, cosmetics, enzymatic catalysis, chemocatalysis

CLC Number: 

  • TQ658