一种降低月桂醇聚醚硫酸酯钠刺激性的清洁组合物性能研究

doi:10.3969/j.issn.2097-2806.2026.07.010

Abstract

Abstract:

Focusing on sodium laureth sulfate（AES）, the irritancy of the AES complex system was studied using red blood cell hemolysis test, zein test, and chicken embryo chorioallantoic membrane test. The results show that sodium hydroxypropyl sulfonate glucoside cross-linked polymer（HLC）, disodium cocoyl glutamate（UCS）, and PEG-80 sorbitan laurate（Tween 28）significantly mitigated the irritancy of AES. The results of dynamic light scattering orthogonal experiment analysis show that the most influential factor is HLC, followed by Tween 28, with UCS having the least impact, with the corresponding optimal combination of being 4% HLC, 4% Tween 28, and 4% UCS. The orthogonal analysis of foam height shows that the most influential factors are Tween 28 and UCS, while HLC has the least influence, yielding an optimal combination of 4% HLC, 2% Tween 28, and 1% UCS. Based on the comprehensive analysis of the value of k in the orthogonal tests, the comprehensive optimal AES complex system is determined to be 4% HLC, 4% Tween 28 and 1% UCS. This combination increases the micelle size through the synergistic effect of steric hindrance and electrostatic repulsion, thereby reducing the irritation of the AES complex system, while maintaining abundant foam, effectively balancing the contradiction between system mildness, cleansing performance, and foaming capability.

Key words: sodium laureth sulfate, thrill, micellar particle size, orthogonal experiment

CLC Number:

TQ423

Mingcheng Wu, Jing Li, Lishi Wu, Huaitong Xie, Xuedong Shi, Panfeng Zhou. Study on the performance of a low-irritation cleaning composition with reducing the irritancy of sodium laureth sulfate[J].China Surfactant Detergent & Cosmetics, 2026, 56(7): 919-924.

Figures/Tables 9

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References 21

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水平	因素
水平	A w（HLC）/%	B w（Tween 28）/%	C w （UCS）/%	D w（AES）/%
1	4	4	4	8
2	2	2	2	8
3	1	1	1	8

实验编号	因素				胶束粒径/nm	泡沫高度/mm
实验编号	A	B	C	D	胶束粒径/nm	泡沫高度/mm
1	1	1	1	1	11.01	141
2	1	2	2	2	6.69	148
3	1	3	3	3	10.35	143
4	2	1	2	3	7.25	145
5	2	2	3	1	3.61	146
6	2	3	1	2	4.18	135
7	3	1	3	2	4.77	145
8	3	2	1	3	4.49	141
9	3	3	2	1	4.02	140

实验编号	因素
实验编号	A	B	C
K₁	28.05	23.03	19.68
K₂	15.04	14.79	17.96
K₃	13.28	18.55	18.73
k₁	9.35	7.68	6.56
k₂	5.01	4.93	5.99
k₃	4.43	6.18	6.24
R	4.92	2.75	0.57

方差来源	离差平方和	自由度	均方	F值	P值	显著性
HLC	43.390	2	21.695	6.248	0.138	无显著性
Tween 28	11.345	2	5.673	1.634	0.380	无显著性
UCS	0.495	2	0.247	0.071	0.933	无显著性
误差	6.945	2	3.472

实验编号	因素
实验编号	A	B	C
K₁	432	431	417
K₂	426	435	432
K₃	426	418	434
k₁	144	144	139
k₂	142	145	144
k₃	142	139	145
R	2	6	6

Study on the performance of a low-irritation cleaning composition with reducing the irritancy of sodium laureth sulfate

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方差来源	离差平方和	自由度	均方	F值	P值	显著性
HLC	8.000	2	4.000	12.000	0.077	无显著性
Tween 28	52.667	2	26.333	79.000	0.013	有显著性
UCS	60.667	2	30.333	91.000	0.011	有显著性
误差	0.667	2	0.333

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