檀香木提取物对皮肤嗅觉受体的影响及功效

doi:10.3969/j.issn.2097-2806.2024.07.010

Abstract

Abstract:

Olfactory receptors （OR） are a class of membrane proteins that can specifically bind to external chemicals （ligands）, thereby inducing intracellular signal transmission. In this work, the impact of aging on OR, the mechanism of sandalwood extract and its clinical efficacies were studied. The relationship between age and OR was studied using reconstructed human epidermis （RHEs） at different ages. The models of senescent RHE and hair follicle dermal papilla cells were established to study the activation of OR2AT4 by sandalwood extract. The role of sandalwood extract in promoting the production of anagen-prolonging factor IGF-1 was studied using hair follicle dermal papilla cell model. The results of in vitro test showed that, the expression of OR2AT4 decreased with age. The level of OR2AT4 in senescent RHE was significantly increased by 46% after treated with 1% sandalwood extract. In addition, 0.002% sandalwood extract could promote the production of IGF-1 in hair follicle dermal papilla cell model, which was significantly increased by 27%. The clinical results demonstrated that, the skin water content, skin tone, skin firmness and wrinkles were all improved after using a cream containing 2% sandalwood extract for 28 days. Hair density was significantly improved after using a scalp serum containing 2% sandalwood for 86 days. In conclusion, sandalwood extract could activate the expression of OR2AT4 and IGF-1 to improve skin aging signs and treat hair loss issue induced by hair follicle aging.

Key words: olfactory receptor, sandalwood extract, skin aging, anti-hair loss, human efficacy test

CLC Number:

TQ658

Yueming Jiang, Wenjia Lu, Xin Qu. Effect of sandalwood extract on olfactory receptor and its clinical efficacy[J].China Surfactant Detergent & Cosmetics, 2024, 54(7): 828-835.

Figures/Tables 12

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References 13

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成分（INCI名称）	w/%
成分（INCI名称）	含2%檀香木提取物配方	安慰剂配方
辛基十二醇、檀香木提取物	1.00	无
硬脂基聚二甲硅氧烷	2.00	2.00
PEG-100硬脂酸酯、硬脂酸甘油酯	2.00	2.00
乳木果油	2.00	2.00
鲸蜡醇乳酸酯	1.50	1.50
辛基十二醇硬脂酸酯	5.00	5.00
棕榈酸乙基己酯	4.00	4.00
EDTA四钠	0.05	0.05
丙烯酸、VP交联聚合物	0.60	0.60
氢氧化钠	0.05	0.05
甘油、甘油丙烯酸酯、丙烯酸共聚物、丙二醇	3.00	3.00
苯氧乙醇、对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丙酯	1.00	1.00
水	至100	至100

成分（INCI名称）	w/%
成分（INCI名称）	含2%檀香木提取物配方	安慰剂配方
辛基十二醇、檀香木提取物	1.00	无
羟乙基纤维素	0.20	0.20
EDTA二钠	0.05	0.05
卡波姆	0.135	0.135
氢氧化钠	0.024	0.024
甘油、甘油丙烯酸酯、丙烯酸共聚物、丙二醇、PVM/MA共聚物	3.00	3.00
甘油硬脂酸酯、山嵛醇、棕榈酸、硬脂酸、卵磷脂、月桂醇、肉豆蔻醇、鲸蜡醇	0.5	0.5
丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、异十六烷、聚山梨醇酯-60	0.1	0.1
苯氧乙醇、1, 3-丙二醇、碳酸丙二醇酯、辛酰羟肟酸、邻伞花烃-5-醇	0.7	0.7
水	至100	至100

功效	参数	样品	平均变化值（D28-D0）	P值	变化率/%
皮肤抗皱	皱纹等级	2%檀香木提取物	-0.53±0.87	0.009^**	-264
皮肤抗皱	皱纹等级	安慰剂	-0.15±0.41	0.009^**	-264
皮肤亮度	L^*值	2%檀香木提取物	0.13±0.19	0.041^*	152
皮肤亮度	L^*值	安慰剂	-0.26±0.19	0.041^*	152
皮肤保湿	角质层含水量	2%檀香木提取物	5.84±1.08	<0.001^****	243
皮肤保湿	角质层含水量	安慰剂	-4.10±0.97	<0.001^****	243
皮肤紧致	R0值	2%檀香木提取物	-0.031±0.008	0.039^*	-77
	R0值	安慰剂	-0.017±0.008	0.039^*	-77
	Q0值	2%檀香木提取物	-6.14±1.65	0.039^*	-77
	Q0值	安慰剂	-3.48±1.58	0.039^*	-77

Effect of sandalwood extract on olfactory receptor and its clinical efficacy

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