4-丁基间苯二酚微乳凝胶制备及美白抗氧化研究

doi:10.3969/j.issn.2097-2806.2024.05.004

Abstract

Abstract:

The 4-butylresorcinol-containing cinnamon oil microemulsion-gel was prepared and its pharmaceutical properties were investigated. Its whitening and antioxidant properties were evaluated. Cinnamon oil microemulsion containing 4-butylresorcinol is clear and transparent in appearance. Its particle size is 15.68 nm and the coefficient of dispersity （PDI） is 0.185. The microemulsion-gel is prepared by using carbopol and Bletilla striata （T.） Reichb. F. polysaccharides as the gel matrix with the pH value at 6.0 and the viscosity at 74.8 Pa·s. In this study, the whitening effect of 4-butylresorcinol-containing cinnamon oil microemulsion-gel was determined by measuring the tyrosinase inhibition. It is shown that the tyrosinase inhibition of 4-butylresorcinol-loaded cinnamon oil microemulsion-gel gradually enhances with its concentration increasing. The tyrosinase inhibition activity of microemulsion-gels is higher than that of the free 4-butylresorcinol and arbutin at the same concentration. The antioxidant effect of 4-butylresorcinol-loaded cinnamon oil microemulsion-gel on hydrogen peroxide （H₂O₂） -induced oxidative damage was tested in B16-F10 cells. The results show that microemulsion-gel has excellent antioxidant effect by reducing ROS production.

Key words: 4-butylresorcinol, cinnamon oil, microemulsion-gel, whitening, antioxidation

CLC Number:

TQ658

Chuyuan Wei, Xiaoping Zhang, Jing Pan, Pei Peng, Yajuan Zhang, Chaofeng Mu. Preparation of 4-butylresorcinol-loaded cinnamon oil microemulsion-gel and its whitening and antioxidative effects[J].China Surfactant Detergent & Cosmetics, 2024, 54(5): 520-526.

Figures/Tables 9

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References 16

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处方	V（油相） ∶V（乳化剂/助乳化剂） ∶V（水相）	外观	离心后	粒径/nm	PDI
①	0.5∶1.5∶4.5	透明，淡蓝色乳光	透明，无沉淀	16.02±0.16	0.103±0.02
②	0.5∶1∶5	近透明，略显淡蓝色乳光	沉淀	204.63±4.77	0.371±0.03
③	1∶1.5∶5	近透明，略显淡蓝色乳光	沉淀	126.00±5.60	0.565±0.03

参数	N₁	N₂	N₃	平均值±SD
粒径/nm	15.64	15.70	15.71	15.68±0.03
PDI	0.193	0.184	0.179	0.185±0.006
Zeta电位/mV	+0.027 1	-0.025 9	-0.032 0	-0.01±0.003

Preparation of 4-butylresorcinol-loaded cinnamon oil microemulsion-gel and its whitening and antioxidative effects

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