硫酸化糖胺聚糖护肤功效研究进展

doi:10.3969/j.issn.2097-2806.2024.12.012

Abstract

Abstract:

With the improvement of consumers’ scientific skin care consciousness, skin problems-oriented efficacy skin care and precise skin care methods have become the future development trend. Glycosaminoglycans are long, linear polysaccharides comprised of repeated disaccharide units, which are highly expressed endogenously in the skin. They are commonly present in skin cells, cell surface and extracellular matrix, with pleiotropic biological function. In addition to hyaluronic acid, the sulfated glycosaminoglycans heparin, heparan sulfate, dermatan sulfate and chondroitin sulfate play an important role in anti-wrinkle, firming, soothing, and improving microvascular circulation, but are still in the research and development stage in cosmetics. This paper summarizes the skincare mechanism of sulfated glycosaminoglycans, and demonstrates the potential of sulfated glycosaminoglycans as functional raw materials in cosmetics.

Key words: sulfated glycosaminoglycans, skin, anti-wrinkle, firming, soothing, microvascular circulation

CLC Number:

TQ658

Yanwei Zhang, Zhongliang Xu, Xi Du, Zhen Li, Zhipeng Tian. Research progress on the skincare efficacy of sulfated glycosaminoglycans[J].China Surfactant Detergent & Cosmetics, 2024, 54(12): 1497-1503.

Figures/Tables 3

References 51

[1]	Gravitz L. Skin[J]. Nature, 2018, 563 (7732) : S83.
[2]	Dong Chailing. The global new ingredients of cosmetics raw material and performance skin care[J]. China Cosmetics Review, 2023, 4: 62-64.
[3]	Anderegg U, Halfter N, Schnabelrauch M, et al. Collagen/glycosaminoglycan-based matrices for controlling skin cell responses[J]. Biological Chemistry, 2021, 402 (11) : 1325-1335. doi: 10.1515/hsz-2021-0176 pmid: 34218546
[4]	Belvedere R, Bizzarro V, Parente L, et al. Effects of Prisma^® Skin dermal regeneration device containing glycosaminoglycans on human keratinocytes and fibroblasts[J]. Cell Adhesion & Migration, 2018, 12 (2) : 168-183.
[5]	Vallet S D, Berthollier C, Ricard-Blum S. The glycosaminoglycan interactome 2.0[J]. American Journal of Physiology Cell Physiology, 2022, 322 (6) : C1271-C1278.
[6]	Pongener I, O’shea C, Wootton H, et al. Developments in the chemical synthesis of heparin and heparan sulfate[J]. Chemical Record (New York, N.Y.), 2021, 21 (11) : 3238-3255.
[7]	Persson A, Nikpour M, Vorontsov E, et al. Domain mapping of chondroitin/dermatan sulfate glycosaminoglycans enables structural characterization of proteoglycans[J]. Molecular & Cellular Proteomics: MCP, 2021, 20: 100074.
[8]	Caterson B, Melrose J. Keratan sulfate, a complex glycosaminoglycan with unique functional capability[J]. Glycobiology, 2018, 28 (4) : 182-206. doi: 10.1093/glycob/cwy003 pmid: 29340594
[9]	Handel T M, Johnson Z, Crown S E, et al. Regulation of protein function by glycosaminoglycans-as exemplified by chemokines[J]. Annual Review of Biochemistry, 2005, 74: 385-410. pmid: 15952892
[10]	Malmström A, Bartolini B, Thelin M A, et al. Iduronic acid in chondroitin/dermatan sulfate: biosynthesis and biological function[J]. The Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society, 2012, 60 (12) : 916-925.
[11]	Lee D H, Oh J H, Chung J H. Glycosaminoglycan and proteoglycan in skin aging[J]. Journal of Dermatological Science, 2016, 83 (3) : 174-181. doi: 10.1016/j.jdermsci.2016.05.016 pmid: 27378089
[12]	Maiti G, Ashworth S, Choi T, et al. Molecular cues for immune cells from small leucine-rich repeat proteoglycans in their extracellular matrix-associated and free forms[J]. Matrix Biology: Journal of the International Society for Matrix Biology, 2023, 123: 48-58.
[13]	Gopal S. Syndecans in inflammation at a glance[J]. Frontiers in Immunology, 2020, 11: 227. doi: 10.3389/fimmu.2020.00227 pmid: 32133006
[14]	Schaefer L, Schaefer R M. Proteoglycans: from structural compounds to signaling molecules[J]. Cell and Tissue Research, 2010, 339 (1) : 237-246. doi: 10.1007/s00441-009-0821-y pmid: 19513755
[15]	Wang S T, Neo B H, Betts R J. Glycosaminoglycans: sweet as sugar targets for topical skin anti-aging[J]. Clinical, Cosmetic and Investigational Dermatology, 2021, 14: 1227-1246. doi: 10.2147/CCID.S328671 pmid: 34548803
[16]	Nikitovic D, Katonis P, Tsatsakis A, et al. Lumican, a small leucine-rich proteoglycan[J]. Iubmb Life, 2008, 60 (12) : 818-823. doi: 10.1002/iub.131 pmid: 18949819
[17]	Lee H, Lim J, Oh J H, et al. IGF-1 upregulates biglycan and decorin by increasing translation and reducing ADAMTS5 expression[J]. International Journal of Molecular Sciences, 2021, 22 (3) : 1403.
[18]	Islam S, Watanabe H. Versican: A dynamic regulator of the extracellular matrix[J]. The Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society, 2020, 68 (11) : 763-775.
[19]	Dos Santos M, Michopoulou A, André-Frei V, et al. Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin[J]. Aging, 2016, 8 (4) : 751-768.
[20]	Rorteau J, Chevalier F P, Fromy B, et al. Functional integrity of aging skin, from cutaneous biology to anti-aging strategies[J]. Medecine Sciences, 2020, 36 (12) : 1155-1162.
[21]	Daquinag A C, Gao Z, Fussell C, et al. Glycosaminoglycan modification of decorin depends on MMP14 activity and regulates collagen assembly[J]. Cells, 2020, 9 (12) : 2646.
[22]	Nomura Y. Structural change in decorin with skin aging[J]. Connective Tissue Research, 2006, 47 (5) : 249-255. pmid: 17118746
[23]	Bucay V, Gold M H. Low molecular weight heparan sulfate containing facial skin care for reducing inflammation and restoring aged-skin homeostasis[J]. Journal of Cosmetic Dermatology, 2020, 19 (8) : 1851-1856. doi: 10.1111/jocd.13528 pmid: 32562303
[24]	Raikou V, Varvaresou A, Panderi I, et al. The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study[J]. Journal of Cosmetic Dermatology, 2017, 16 (2) : 271-278. doi: 10.1111/jocd.12314 pmid: 28150423
[25]	Roig-Rosello E, Rousselle P. The human epidermal basement membrane: a shaped and cell instructive platform that aging slowly alters[J]. Biomolecules, 2020, 10 (12) : 1607.
[26]	Wen S, Wu J, Ye L, et al. Topical applications of a heparinoid-containing product attenuate glucocorticoid-induced alterations in epidermal permeability barrier in mice[J]. Skin Pharmacology and Physiology, 2021, 34 (2) : 86-93.
[27]	Tsunenaga M. Heparanase inhibitors facilitate the assembly of the basement membrane in artificial skin[J]. Current Tissue Engineering, 2016, 5 (2) : 113-122. pmid: 27853671
[28]	Koffi Teki D S, Coulibaly B, Bil A, et al. Synthesis of novel S- and O-disaccharide analogs of heparan sulfate for heparanase inhibition[J]. Organic & Biomolecular Chemistry, 2022, 20 (17) : 3528-3534.
[29]	Bucay V, Gold M H, Andriessen A. Low molecular weight heparan sulfate containing facial skin care for reducing inflammation and restoring aged-skin homeostasis[J]. Journal of Cosmetic Dermatology, 2020, 19 (8) : 1851-1856. doi: 10.1111/jocd.13528 pmid: 32562303
[30]	Colvan L, Fleck T, Vega V L. Global periorbital skin rejuvenation by a topical eye cream containing low molecular weight heparan sulfate (LMW-HS) and a blend of naturally derived extracts[J]. Journal of Cosmetic Dermatology, 2019, 18 (2) : 530-538. doi: 10.1111/jocd.12857 pmid: 30636356
[31]	De Araújo R, Lôbo M, Trindade K, et al. Fibroblast growth factors: a controlling mechanism of skin aging[J]. Skin Pharmacology and Physiology, 2019, 32 (5) : 275-282. doi: 10.1159/000501145 pmid: 31352445
[32]	Zhang F, Zheng L, Cheng S, et al. Comparison of the interactions of different growth factors and glycosaminoglycans[J]. Molecules (Basel, Switzerland), 2019, 24 (18) : 3360.
[33]	Bäsler K, Brandner J M. Tight junctions in skin inflammation[J]. Pflugers Archiv: European Journal of Physiology, 2017, 469 (1) : 3-14. doi: 10.1007/s00424-016-1903-9 pmid: 27853878
[34]	Crijns H, Vanheule V, Proost P. Targeting chemokine-glycosaminoglycan interactions to inhibit inflammation[J]. Frontiers in Immunology, 2020, 11: 483. doi: 10.3389/fimmu.2020.00483 pmid: 32296423
[35]	Farrugia B L, Lord M S, Melrose J, et al. The role of heparan sulfate in inflammation, and the development of biomimetics as anti-inflammatory strategies[J]. The Journal of Histochemistry and Cytochemistry, 2018, 66 (4) : 321-336.
[36]	George R, Gallo R L, Cohen J L, et al. Reduction of erythema in moderate-severe rosacea by a low molecular weight heparan sulfate analog (HSA)[J]. Journal of Drugs in Dermatology: JDD, 2023, 22 (6) : 546-553.
[37]	Gross A R, Theoharides T C. Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33[J]. Biofactors, 2019, 45 (1) : 49-61. doi: 10.1002/biof.1464 pmid: 30521103
[38]	Utsunomiya R, Dai X. Heparinoid suppresses Der p-induced IL-1β production by inhibiting ERK and p38 MAPK pathways in keratinocytes[J]. Experimental Dermatology, 2018, 27 (9) : 981-988. doi: 10.1111/exd.13685 pmid: 29754454
[39]	Makino-Okamura C, Niki Y, Takeuchi S, et al. Heparin inhibits melanosome uptake and inflammatory response coupled with phagocytosis through blocking PI3k/Akt and MEK/ERK signaling pathways in human epidermal keratinocytes[J]. Pigment Cell & Melanoma Research, 2014, 27 (6) : 1063-1074.
[40]	Zdrada-Nowak J, Stolecka-Warzecha A. The assessment of moderate acne vulgaris face skin using blood perfusion and hyperspectral imaging: A pilot study[J]. Journal of Cosmetic Dermatology, 2023, 22 (11) : 3143-3151.
[41]	Jiang W C, Zhang H, Xu Y, et al. Cutaneous vessel features of sensitive skin and its underlying functions[J]. Skin Research and Technology, 2020, 26 (3) : 431-437.
[42]	He Li. The guide for topical use of skin lightening cosmetics in the treatment of melasma[J]. The Chinese Journal of Dermatovenereology, 2022, 36 (2) : 123-127.
[43]	Chung J H, Eun H C. Angiogenesis in skin aging and photoaging[J]. The Journal of Dermatology, 2007, 34 (9) : 593-600.
[44]	Lee J H, Yoo J H, Oh S H, et al. Knockdown of moesin expression accelerates cellular senescence of human dermal microvascular endothelial cells[J]. Yonsei Medical Journal, 2010, 51 (3) : 438-447. doi: 10.3349/ymj.2010.51.3.438 pmid: 20376899
[45]	Fei Wenmin, Tang Huayang, Yang Sen, et al. Changes of cutaneous microcirculatory in psoriasis[J]. The Chinese Journal of Dermatovenereology, 2018, 21 (6) : 714-717.
[46]	Chiodelli P, Bugatti A, Urbinati C, et al. Heparin/Heparan sulfate proteoglycans glycomic interactome in angiogenesis: biological implications and therapeutical use[J]. Molecules (Basel, Switzerland), 2015, 20 (4) : 6342-6388.
[47]	Kuwahara-Watanabe K, Hidai C, Ikeda H, et al. Heparin regulates transcription of endothelin-1 gene in endothelial cells[J]. Journal of Vascular Research, 2005, 42 (3) : 183-189. pmid: 15785094
[48]	Denzinger M, Held M, Amr A, et al. The influence of topically administered heparin on peripheral microcirculation of the skin: a double-blind, randomized, controlled preliminary study on 50 healthy subjects[J]. Journal of Reconstructive Microsurgery, 2021, 37 (8) : 694-703. doi: 10.1055/s-0041-1726028 pmid: 33792003
[49]	Foote C A, Soares R N, Ramirez-Perez F I, et al. Endothelial glycocalyx[J]. Comprehensive Physiology, 2022, 12 (4) : 3781-3811.
[50]	Zhao Yaping. N-desulfated / acetylated heparin ameliorates the shedding of glycocalyx in septic mice[D]. Jinan: Shandong University, 2019.
[51]	Huang Yueting, Pan Ye, Jiang Yujie, et al. Study of damage and protection of endodermal glycocalyx in rats with rear limb venous hypertension[J]. Chinese Journal of Vascular Surgery (Electronic Version), 2020, 12 (1) : 42-46.

		单糖2
		葡萄糖醛酸（GlcUA）	艾杜糖醛酸（IdoUA）	半乳糖（Galactose）
单糖1	N-乙酰葡糖胺（GlcNAc）	HS ^[6,10]	—	KS ^[8]
单糖1	N-乙酰半乳糖胺（GalNAc）	CS ^[7]	DS ^[7]	—

蛋白聚糖	核心蛋白/kDa	糖胺聚糖链	皮肤中的位置	参考文献
Syndecan家族	22~43	多条CS和HS（多种亚型）	表皮层：跨膜/细胞外基质	[13]
Decorin	36	1条CS或DS（皮肤中DS居多）	真皮层：细胞外基质	[12]
Lumican	37	2~3条KS-I	真皮层：细胞外基质	[16]
Biglycan	38	2条CS或DS	真皮层：细胞外基质	[17]
Versican	72~373	多条CS	表皮层/真皮层：细胞外基质	[18]
Perlecan	400~450	3条HS	真皮表皮连接处	[19]

Research progress on the skincare efficacy of sulfated glycosaminoglycans

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