消毒剂对重组Ⅲ型人源化胶原蛋白促细胞黏附活性的影响

doi:10.3969/j.issn.2097-2806.2023.07.008

Abstract

Abstract:

The disinfectants available for facial injectable fillers include 75% ethanol, iodine-containing and surfactant-based disinfectants. There is a lack of research on whether the use of various skin disinfectants influences the activity of recombinant type Ⅲ humanized collagen （rhCol Ⅲ）. The toxicity of 75% ethanol, iodophor disinfectant, chlorhexidine gluconate, benzalkonium chloride, and benzalkonium bromide on cells and the cell adhesion activity of rhCol Ⅲ were investigated by CCK8 experiments to predict the effect of disinfectant on collagen activity during facial fillers, in order to provide guidance for clinical application. The results show that all disinfectants have cytotoxicity to NIH/3T3 mouse embryonic fibroblasts and HFB human skin fibroblasts, and the comparative results rank as chlorhexidine gluconate

Key words: recombinant humanized collagen, filler, disinfectant, cytotoxicity, cell adhesion activity

CLC Number:

TQ658

Li Yitong, Sun Yanyan, Qiao Shaojun, Hou Lili, Li Manqin, Yu Yufeng. Effect of disinfectants on cell adhesion activity of recombinant type Ⅲ humanized collagen[J].China Surfactant Detergent & Cosmetics, 2023, 53(7): 789-895.

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References 16

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Effect of disinfectants on cell adhesion activity of recombinant type Ⅲ humanized collagen

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