过硫酸氢钾复合物消毒剂的制备及杀菌性能研究

doi:10.3969/j.issn.1001-1803.2019.08.005

Abstract

Abstract:

A non-chlorine potassium peroxymonosulfate disinfectant was prepared. The disinfectant was prepared with potassium peroxymonosulfate as the main component and amino sulfonic acid and surfactant as the auxiliary materials. The stability of the sample aqueous solution was investigated by detecting the peroxide concentration of the sample aqueous solution for 0-6 hours, and the formula of disinfectant was determined by orthogonal test. The germicidal efficacy had been done against Escherichia coli, Staphylococcus aureus and Candida albicans. The results show that the peroxide concentration in 1% aqueous solution is stable within 6 hours. Under the condition of（20±1） ℃ water bath, the mean killing logarithmic values of 1% aqueous solution to Eescherichia coli and Staphylococcus aureus for 5 min are greater than 5.00; the mean killing logarithmic values of 2% aqueous solution acting on Candida albicans for 10 min are greater than 4.00. The active components of the non-chloride disinfectant prepared by potassium peroxymonosulfate and sulfamic acid are stable in aqueous solution and have ideal killing effect.

Key words: potassium peroxymonosulfate, disinfectant, sterilization

CLC Number:

R187

WANG Zhan-yin,GAO Wen-jun,WEI Gang,ZHANG Zheng-ming. Preparation and bactericidal properties of potassium peroxymonosulfate disinfectant[J].China Surfactant Detergent & Cosmetics, 2019, 49(8): 515-518.

Figures/Tables 7

Tab. 1

Tab. 2

Tab. 3

Tab. 4

Tab. 5

Tab. 6

Tab. 7

References 20

[1]	Peng Min, Lu Sihao, Fan Hongbo . Comparison of disinfection effect of sodium hypochlorite with different free alkali contents and disinfection by-products[J]. Water & Wastewater Engineering, 2016,42(7) : 12-14.
[2]	Zhao Yuping . Reports of injuries to nurses caused by improper use of chlorine-containing disinfectants[J]. Chinese Journal of Disinfection, 2004,21(1) : 72-73.
[3]	Du Junqi, Dong Yuemei, Zhang Surong , et al. Study on preparation technology of reactive oxygen disinfectant and air disinfection effect[J]. Journal of Beijing University of Chemical Technology, 2003,30(6) : 14-17.
[4]	Yan Xiaoling . Study on potassium monopersulfate in laboratory[J]. Chinese Journal of Health Laboratory Technology, 2007,17(4) : 631-632.
[5]	Zhao Hong, Su Jing, Liu Xiaoyong , et al. Comparison and evaluation of germicidal efficacy of two different disinfectants on surface of objects in clinical laboratory[J]. Chinese Journal of Nosocomiology, 2011 ( 19) : 4085-4086.
[6]	Chen Weijie, Chen Zhaobin . Recent development of new disinfection technologies in China[J]. Chinese Journal of Disinfection, 2018,35(5) : 376-379.
[7]	Liu Weiyan . The application of a new type of peroxide disinfectant in the disinfection of swimming pool water[J]. Chinese Journal of Disinfection, 2016,33(6) : 533-536.
[8]	Li Na . Evaluation of disinfection effect of compound salt granules of potassium persulfate[D]. Nanjing: Nanjing Agricultural University, 2016.
[9]	Feng Xiu, Wang Ailing, Zhang Zhencang , et al. Study on the optimal bactericidal conditions of potassium persulfate complex[J]. Progress in Veterinary Medicine, 2017,38(8) : 39-42.
[10]	Yang Yanlin, Yu Hongzhong, Xu Hui . Observation of bactericidal effect of potassium persulfate compound disinfectant[J]. Chinese Journal of Disinfection, 2008,25(2) : 150-152.
[11]	Zhang Yuehua, Zhao Yongxun . Experimental study on disinfection effect of potassium persulfate compound salt[J]. Chinese Journal of Health Laboratory Technology, 2005,15(1) : 40-41.
[12]	Fu Weixing . Study on disinfection of the compound peroxymonosulphatepowder[D]. Chinese Academy of Agricultural Sciences, 2011.
[13]	Song Haipeng, Li Peihong. Compound potassium persulfate disinfectant and its manufacturing process: CN201110149685.2[P] . 2011 -06-03.
[14]	Yu Jingru, Li bo, Li Zhongliang , et al. The disinfectant powder and the preparation method thereof: CN200610021376.6[P]. 2006 -07-11.
[15]	Department of health legislation and supervision. Technical specifications for disinfection[S]. Beijing: Ministry of Health, 2002.
[16]	Qiao Liping, Huang Yinjun, Xue Feiqun , et al. Experiment of potassium persulfate compound powder against foot-and-mouth disease virus[J]. Hubei Agricultural Science, 2013,52(8) : 1877-1879.
[17]	Qin Tao, Wang Chuanwei, Shi Baolan , et al. Study on the inactivation effect of four common disinfectants on H7N9 subtype influenza virus[J]. Animal Husbandry & Veterinary Medicine, 2008,50(8) : 64-68.
[18]	He Saiqin, Wang Caiya, Yang Guoling , et al. Effect analysis of single potassium persulfate compound salt on disinfection of digestive endoscopic cleaning tank[J]. Shanghai Journal of Preventive Medicine, 2013,25(6) : 359-360.
[19]	Zhang Yuehua, Zou Chunying, Zhang Jiao , et al. Application of potassium persulfate compound salt in edible fungi production[J]. Journal of Agro-Environment Science, 2006,25:280-282.
[20]	Yang Ning, Lai Fawei, Liu Keliang , et al. Study on bactericidal effect and toxicology of potassium persulfate compound salt[J]. Chinese Journal of Disinfection, 2007,24(3) : 222-225.

水平	A w（氨基磺酸）/%	B w（柠檬酸）/%	C w（EDTA）/%	D w（TX-10）/%
1	12	11	0.5	0.4
2	14	13	1.0	0.8
3	16	15	1.5	1.2

序号	A	B	C	D	c（KHSO₅）/（mmol·L^-1）				RSD/%
序号	A	B	C	D	0 h	2 h	4 h	6 h	RSD/%
1 2 3 4 5 6 7 8 9	1 2 3 1 2 3 1 2 3	1 1 1 2 2 2 3 3 3	1 2 3 2 3 1 3 1 2	1 2 3 3 1 2 2 3 1	21.05 21.05 20.89 21.00 21.13 21.15 20.90 21.06 20.96	21.05 20.72 19.89 21.00 21.06 21.11 21.02 20.90 21.01	21.27 20.67 20.37 20.72 21.03 21.07 21.00 21.03 20.90	21.03 20.68 20.36 21.00 20.96 21.20 20.84 21.00 20.89	0.54 0.87 2.00 0.67 0.33 0.26 0.41 0.33 0.27
K₁	1.62	3.41	1.13	1.14
K₂	1.53	1.26	1.81	1.54
K₃	2.53	1.01	2.74	3.00
k₁	0.540 0	1.136 7	0.376 7	0.380 0
k₂	0.510 0	0.420 0	0.603 3	0.513 3
k₃	0.843 3	0.336 7	0.913 3	1.000 0
R	0.333 3	0.800 0	0.536 7	0.620 0

样品	c（KHSO₅）/（mmol·L^-1）				RSD/%
样品	0 h	2 h	4 h	6 h	RSD/%
1	20.96	20.88	20.97	20.86	0.27
2	21.06	21.08	21.05	20.98	0.21
3	20.93	21.02	20.95	20.86	0.31

组别	各组生长细菌数/（cfu·mL^-1）			平均生长菌落数/（cfu·mL^-1）
组别	1	2	3	平均生长菌落数/（cfu·mL^-1）
1	0	0	0	0
2	0	0	0	0
3	2.90×10⁶	3.45×10⁶	2.25×10⁶	2.87×10⁶
4	2.60×10⁶	2.65×10⁶	1.80×10⁶	2.35×10⁶
5	2.20×10⁶	3.75×10⁶	2.15×10⁶	2.70×10⁶

组别	各组生长细菌数/（cfu·mL^-1）			平均生长菌落数/（cfu·mL^-1）
组别	1	2	3	平均生长菌落数/（cfu·mL^-1）
1	000	000	000	000
2	250	465	135	283
3	2.60×10⁶	2.65×10⁶	2.00×10⁶	2.42×10⁶
4	2.65×10⁶	2.75×10⁶	2.45×10⁶	2.62×10⁶
5	3.25×10⁶	3.05×10⁶	2.90×10⁶	3.07×10⁶

Preparation and bactericidal properties of potassium peroxymonosulfate disinfectant

RichHTML

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 7

References 20

Related Articles 5

Metrics

Comments

Recommended 10

组别	各组生长细菌数/（cfu·mL^-1）			平均生长菌落数/（cfu·mL^-1）
组别	1	2	3	平均生长菌落数/（cfu·mL^-1）
1	270	945	415	543
2	2.31×10³	2.54×10³	1.76×10³	2.20×10³
3	2.90×10⁵	4.25×10⁵	2.65×10⁵	3.27×10⁵
4	2.40×10⁵	3.85×10⁵	2.35×10⁵	2.87×10⁵
5	3.45×10⁵	4.40×10⁵	3.40×10⁵	3.75×10⁵

试验菌株	w（YSK水溶液）/%	阳性对照组平均菌落数的对数值	作用不同时间（min）的平均杀灭对数值
试验菌株	w（YSK水溶液）/%	阳性对照组平均菌落数的对数值	5	10	15
大肠杆菌	1	7.52	﹥7.52	﹥7.52	﹥7.52
大肠杆菌	1	7.52	﹥7.41~7.63	﹥7.41~7.63	﹥7.41~7.63
金黄色葡萄球菌	1	7.58	﹥7.58	﹥7.58	﹥7.58
金黄色葡萄球菌	1	7.58	﹥7.47~7.63	﹥7.47~7.63	﹥7.47~7.63
白色念珠菌	2	6.54	3.19	﹥6.54	﹥7.58
白色念珠菌	2	6.54	﹥3.03~3.40	﹥6.46~6.60	﹥6.46~6.60

[1]	Li Yitong, Sun Yanyan, Qiao Shaojun, Hou Lili, Li Manqin, Yu Yufeng. Effect of disinfectants on cell adhesion activity of recombinant type Ⅲ humanized collagen [J]. China Surfactant Detergent & Cosmetics, 2023, 53(7): 789-895.
[2]	Yang Jie,Yao Chenzhi,Yan Fang,Wang Jie,Li Xiaoting. An evaluation method for sterilization performance of fabric detergents [J]. China Surfactant Detergent & Cosmetics, 2022, 52(6): 672-676.
[3]	Lin Xianjia,Cao Yan,Luo Wenyi,Lin Zhen,Zhang Zhiguo,Wen Yanmei. Study on the preparation and antibacterial properties of antibacterial hand sanitizers containing dodecyl dipropylene triamine [J]. China Surfactant Detergent & Cosmetics, 2022, 52(4): 376-382.
[4]	WANG Ping, YANG Xu-zhao, ZOU Wen-yuan, XU Qing-jie, WANG Jun. Synthesis and application of ionic liquid surfactants (Ⅸ) Bactericidal performance [J]. China Surfactant Detergent & Cosmetics, 2017, 47(9): 487-491.
[5]	ZHAO Liu-chen, ZHANG Hui, WANG Wan-xu, WANG Guo-yong. Effect of nonionic surfactants on the bactericidal performance of the composite cationic disinfectant [J]. China Surfactant Detergent & Cosmetics, 2017, 47(4): 192-196.