利用离体牛角膜多次暴露方法评测化妆品套装的眼刺激性

doi:10.13218/j.cnki.csdc.2018.02.010

Abstract

Abstract: Five commercially available cosmetic kits were evaluated by using the standard and modified bovine corneal opacity and permeability (BCOP) test,and the changes of opacity and permeability were compared in different test alternatives,developed a preliminary evaluation method of in vitro bovine corneal multi-exposure.Results show that according to the standard test method,each of five kits tested is non-irritation.On the other hand,the five kits,by the modified test,may cause eye irritation resulted from the various changes of opacity and permeability of the corneas.In conclusion,the modified BCOP test is demonstrated to be an appropriate method for multi-exposure eye irritation assessment of cosmetic kits,which can provide reference for improving product safety.

Key words: cosmetics, eye irritation, bovine cornea, multi-exposure

CLC Number:

TQ658

HUANG Jian-cong, CHEN Zhi-jie, CHEN Yi-zhu, QIN Yao. Assessment of cosmetic kits on eye irritation by using multi-exposure method of in vitro bovine cornea[J].China Surfactant Detergent & Cosmetics, 2018, 48(2): 109-112.

References

[1] 程树军.化妆品评价替代方法标准实施指南[M].北京:中国质检出版社,2017:145-187.
[2] OECD.guidance document on an integrated approaches on testing and assessment for serious eye damage and eye irritation.series on testing and assessment No.263 [S].Paris:OECD,2017.
[3] 黄健聪,秦瑶,程树军,等.牛角膜浑浊渗透试验方法预测眼刺激性的研究[J].中国卫生检验杂志,2014,24(14):1980-1983.
[4] 陈彧,陆瑞强,程树军,等.利用牛角膜浑浊渗透性方法检测纸质卫生用品对皮肤刺激性研究[J].日用化学品科学,2017,40(6):1-4.
[5] 秦瑶,柯逸晖,程树军,等.牛角膜浑浊和渗透性实验应用于个人护理产品评价的案例分析[J].日用化学品科学,2017,40(3):13-17.
[6] 程树军,秦瑶,柯逸晖,等.替代方法在化妆品检测中的应用分析[J].中国比较医学杂志,2017,27(10):101-106.
[7] 陈彧,喻欢,程树军,等.结合组织学评分的牛角膜浑浊和渗透性方法研究[J].日用化学工业,2016,46(2):106-110.
[8] Ubels J L,Pruis R M,Sybesma J T,et al.Corneal opacity,hydration and endothelial morphology in the bovine cornea opacity and permeability assay using reduced treatment times [J].Toxicol.in Vitro,2000,14(4):379-386.
[9] OECD.Bovine corneal opacity and permeability test method for identi-fying i) chemicals inducing serious eye damage and ii) chemicals not requiring classification for eye irritation or serious eye damage.OECD guideline for testing of chemicals section 4 health effect No.437 [S].Paris:OECD,2017.
[10] Spöler F,Frentz M,Schrage N F.Towards a new in vitro model of dry eye:the ex vivo eye irritation test [J].Dev Ophthalmol,2010,45:93-107.
[11] 秦瑶,程树军,黄健聪,等.整合CAMVA和BCOP方法检测化妆品的眼刺激性[J].中国比较医学杂志,2014,24(6):78-82.
[12] Hayashi K,Mori T,Abo T,et al.A tiered approach combining the short time exposure (STE) test and the bovine corneal opacity and permeability (BCOP) assay for predicting eye irritation potential of chemicals [J].Toxicol.Sci.,2012,37(2):269-280.
[13] Donahue D A,Kaufman L E,Avalos J,et al.Survey of ocular irritation predictive capacity using Chorioallantoic Membrane Vascular Assay (CAMVA) and Bovine Corneal Opacity and Permeability (BCOP) test historical data for 319 personal care products over fourteen years [J].Toxicol.in Vitro,2011,25(2):563-572.
[14] 中华人民共和国卫生部.化妆品安全性评价程序和方法:GB 7919-1987 [S].北京:中国标准出版社,1987.

[1]	Jingxuan Liu, Jianming Jin, Hua Wu. Botanical cosmetic ingredients （VII）Research and development of plant antifungal [J]. China Surfactant Detergent & Cosmetics, 2024, 54(3): 259-266.
[2]	Wu Bi, Xiaohong Pan, Xiaoqin Tu, Shuai Yin, Hui Sun. Analysis of the mechanism of anti-sensitive skin effect of cosmetic raw material Stephania tetrandra based on network pharmacology [J]. China Surfactant Detergent & Cosmetics, 2024, 54(3): 305-312.
[3]	Yaoyao Li. Study on the anti-aging and antioxidant effects of isosinensetin [J]. China Surfactant Detergent & Cosmetics, 2024, 54(3): 313-319.
[4]	Liyuan Zhang, Linqi Yan, Qiaoyuan Cheng, Lvye Qi, Rong Wang, Liuqian Huang. Determination of 14 kinds of α-hydroxy acids and hydroxy esters in cosmetics [J]. China Surfactant Detergent & Cosmetics, 2024, 54(3): 353-359.
[5]	Wei Xu, Po Zou, Changyu Li, Ming Yang, Yan Lu, Huiliang Li. Determination of 36 stimulants in cosmetics by ultra performance liquid chromatography-tandem mass spectrometry [J]. China Surfactant Detergent & Cosmetics, 2024, 54(3): 360-368.
[6]	Kangfu Zhou, Yixuan Zhi, Feifei Wang, Yazhuo Shang. New emulsion system and its application in cosmetics （VI）Microemulsion [J]. China Surfactant Detergent & Cosmetics, 2024, 54(2): 139-148.
[7]	Zhen Xie, Wei Huang, Jinsong Zhang, Shuhuai Chen, Linji Qu, Rong Kuang. Study on biomarkers of corneal injury in the evaluation of eye irritation of cosmetics [J]. China Surfactant Detergent & Cosmetics, 2024, 54(2): 161-167.
[8]	Xiaohong Pan, Ziqi Gao, Zhen Chen, Shuai Yin, Haiping Huang, Bin Hu. Discussion on the current situation of research and management on the stability of cosmetic products in China [J]. China Surfactant Detergent & Cosmetics, 2024, 54(2): 201-208.
[9]	Li Lu, Fang Fang, Youlong Feng, Ling Cao. Screening for illegal addition of sulfonamides in cosmetic products using ultra-performance liquid chromatographytriple quadrupoletandem mass spectrometry with precursor ion scanning [J]. China Surfactant Detergent & Cosmetics, 2024, 54(2): 216-223.
[10]	Ren Wang, Yuanyang Wu, Jia Qiao, Linqi Yan, Cen Chen, Liyuan Zhang. Study on phenoxyethanol content in children’s cosmetics on the mark and preliminary risk assessment [J]. China Surfactant Detergent & Cosmetics, 2024, 54(2): 224-230.
[11]	Yixiang Lu, Liting Wu, Jimin Jiang, Hailu Chen, Xuan Huang. Determination of tolnaftate and liranaftate in cosmetics by high performance liquid chromatography and verification by high performance liquid chromatography-tandem mass spectrometry [J]. China Surfactant Detergent & Cosmetics, 2024, 54(2): 231-238.
[12]	Liyuan Zhang, Qiaoyuan Cheng, Cen Chen, Zehua Li, Liuqian Huang, Lvye Qi. Determination of 3 kinds of α-hydroxy acids and their esters in cosmetics by high performance liquid chromatography [J]. China Surfactant Detergent & Cosmetics, 2024, 54(1): 102-106.
[13]	Linling Lu, Hui Lu, Chunyan Min, Yefei Qian. Determination of functional components of Glycyrrhizae, Ginseng and Scutellariae in facial masks by UHPLC-MS/MS [J]. China Surfactant Detergent & Cosmetics, 2024, 54(1): 107-113.
[14]	Xu Han, Jiajia Wu, Na Wu, Yazhuo Shang. New emulsion system and its application in cosmetics （V） Janus emulsion [J]. China Surfactant Detergent & Cosmetics, 2024, 54(1): 24-31.
[15]	Feng Liu, Yuanchang Deng, Guohong Ying, Xiaowei Wang. Establishment of duplex-PCR method for rapid detection of Pluralibacter gergoviae [J]. China Surfactant Detergent & Cosmetics, 2024, 54(1): 45-50.

Assessment of cosmetic kits on eye irritation by using multi-exposure method of in vitro bovine cornea

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10