Abstract: Efficacy of Tricholoma matsutake extract (TME) for anti-senility of human skin were examined via experiments for scavenging of hydroxyl free radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals as well as experiment for non-enzymatic glycosylation inhibition.Results indicated that TME shows good scavenging efficacy on hydroxyl free radicals and DPPH free radicals as well as good inhibition effect for the non-enzymatic glycosylation,and the effects is closely related with the content of TME in the reaction mixture.With 4% of TME volume fraction adopted,hydroxyl free radicals scavenging ratio reaches 89.6%,and with 25% TME volume fraction adopted,DPPH free radicals scavenging ratio reaches 96.4%.Moreover,non-enzymatic glycosylation inhibition ratio can reach 91.5% with 20.0% TME volume fraction adopted and culturing for 14 d.

Key words: anti-senility, Tricholoma matsutake extract, radical, non-enzymatic glycosylation reaction