当归净油抗衰老及抗炎祛痘功效的体外实验研究

doi:10.13218/j.cnki.csdc.2017.02.006

Abstract

Abstract: Via a model of human dermal fibroblasts-adult (HDF-a),effects of Angelica sinensis absolute oil (ASO) on the secretion of collagen type Ⅰ (Col-Ⅰ) by the HDF-a cells were examined.Results showed that when the ASO is at its maximum safety mass concentration for the HDF-a cells 25 mg/L,the secretion of Col-Ⅰ in HDF-a cells can be effectively increased by 33.5%.In addition,an inflammatory acne model was established by stimulating human acute mononuclear cells THP-1 cells with Propionibacterium acnes (P.acnes).Results showed that when ASO is at its maximum safety mass concentration for the THP-1 cells 12.5 mg/L,the ASO can inhibit the release of inflammatory cytokines IL-1β from P.acnes treated THP-1 cells by 94.51%.When the mass concentration is halved to 6.25 mg/L,the ASO still can significantly inhibit IL-1β secretion by 64.34%.Hence,ASO is a natural plant perfume raw material that displays anti-senility and anti-inflammatory acne effects in personal care activities and is expected to be further developed and applied in cosmetics.

Key words: cosmetic additive, Angelica sinensis, anti-senility, anti-inflammatory acne, perfume plants

CLC Number:

TQ658

WANG Yue, YU Hai-yuan, SHI Yan-qin, PAN Xian-hua, LU Yan-hua, CAO Ping. In vitro test for examination of anti-senility and anti-inflammatory acne effects of absolute oil from Angelica sinensis (Oliv.) Diels[J].China Surfactant Detergent & Cosmetics, 2017, 47(2): 87-89.

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In vitro test for examination of anti-senility and anti-inflammatory acne effects of absolute oil from Angelica sinensis (Oliv.) Diels

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