Abstract: An analysis method was established for the simultaneous determination of binapacryl and propargite in acaricidal cosmetics using gas chromatography-mass spectrometry (GC-MS).Samples were extracted by acetonitrile and purified with matrix solid-phase dispersion extraction (MSPD).The purified extracts were separated by weak polar capillary column (HP-5MS) and components were detected with selected ion monitoring (SIM) scanning mode.Quantification was carried out using matrix-matched standard curve calibration.The results showed that when the mass fraction of binapacryl and propargite is in the range of 6.0-40.0 mg/kg,the content data displays good linear relationship with the response of the instrument and the correlation coefficients (R²) are all more than 0.995.The limits of detection of binapacryl and propargite are all 2.0 mg/kg and the limits of quantification are all 6.0 mg/kg.Under condition of mass fraction of 6.0 and 40.0 mg/kg,all RSD of data of precisions and repeatability for binapacryl and propargite are less than 5%.Values of spiked recoveries tested with addition of binapacryl on the levels of 6.0,20.0 and 40.0 mg/kg are found to be from 76.2% to 93.1%.The spiked recoveries of propargite on the same levels are from 77.2% to 95.0%.

Key words: cosmetics, gas chromatography-mass spectrometry, binapacryl, propargite