曲酸金属配合物的合成与酪氨酸酶抑制性能研究

doi:10.13218/j.cnki.csdc.2014.12.153

Abstract

Abstract: Four kinds of metal complex of kojic acid (KA),KA-Fe(Ⅲ),KA-Cu(Ⅱ),KA-Mn(Ⅱ) and KA-Zn(Ⅱ) were prepared by complexing reaction through kojic acid and metal ion compounds.Their chemical structures were characterized by infrared spectra,differential thermal gravimetric analysis and ultraviolet spectra.Their tyrosinase inhibitory action was examined.Results showed that the tyrosinase inhibitory effect of KA-Fe(Ⅲ),KA-Zn(Ⅱ) and KA-Mn(Ⅱ) are remarkable.Their corresponding IC₅₀ is 25,18 and 62 μmol·L^-1 respectively (while IC₅₀ of kojic acid is 70 μmol·L^-1).Based upon analysis of their inhibitory mechanism,the type of inhibitory action of this series of compound is all considered as non-competitive inhibition.

Key words: additive of cosmetics, kojic acid metal complex, tyrosinase inhibitor, non-competitive

CLC Number:

TQ658

YANG Pei, ZHANG Yi-wei. Synthesis and tyrosinase inhibitory activity of kojic acid metal complexes[J].China Surfactant Detergent & Cosmetics, 2014, 44(12): 688-691.

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Synthesis and tyrosinase inhibitory activity of kojic acid metal complexes

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