十一碳烯酰基苯丙氨酸的合成及其抑制酪氨酸酶二酚酶活性的研究

doi:10.13218/j.cnki.csdc.2016.10.009

Abstract

Abstract: Undecylenic acid and L-phenylalanine were used as main materials to prepare N-undecenoyl-L-phenylalanine.The undecylenic acid was acyl-chlorinated with thionyl chloride via Schotten-Baumann reaction,followed by acidification;then the target product,N-undecenoyl-L-phenylalanine was obtained.The product was characterized by IR,MS and ¹H NMR.Meanwhile,the mechanism for inhibitory effect on tyrosinase diphenolase activity of N-undecenoyl-L-phenylalanine was investigated.Results showed that the inhibitory effect on tyrosinase diphenolase activity of N-undecenoyl-L-phenylalanine is competitive and reversible inhibition.Its 50% effective inhibitory concentration is 3.711 g/L,and its inhibition constant (K_i) is 3.651 g/L.

Key words: additives of whitening cosmetics, N-undecenoyl-L-phenylalanine, tyrosinase inhibitor, competitive and reversible inhibition

CLC Number:

TQ658

XU Kai,XU Hu-jun. Synthesis and inhibitory effect on tyrosinase diphenolase activity of N-undecenoyl-L-phenylalanine[J].China Surfactant Detergent & Cosmetics, 2016, 46(10): 591-595.

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Synthesis and inhibitory effect on tyrosinase diphenolase activity of N-undecenoyl-L-phenylalanine

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