过硫酸氢钾复合物消毒剂的制备及杀菌性能研究

doi:10.3969/j.issn.1001-1803.2019.08.005

摘要/Abstract

摘要：

以过硫酸氢钾复合物为主成分,氨基磺酸、表面活性剂等为辅料制备一种不含氯成分的过硫酸氢钾复合物消毒剂。以检测样品水溶液0~6 h的过氧化物浓度变化来考察样品水溶液的稳定性,通过正交试验确定消毒剂配方,并以大肠杆菌、金黄色葡萄球菌、白色念珠菌为受试菌株进行细菌定量杀灭试验。试验结果表明,1%样品水溶液中过氧化物浓度在6 h内稳定;在（20±1） ℃水浴条件下,1%水溶液对大肠杆菌、金黄色葡萄球菌作用5 min,杀灭对数值均大于5.00;2%水溶液对白色念珠菌作用10 min,杀灭对数值均大于4.00。用过硫酸氢钾复合物、氨基磺酸等制备的消毒剂样品,其有效成分在水溶液中稳定,具有理想的消杀效果。

关键词: 过硫酸氢钾复合物, 消毒剂, 杀菌

Abstract:

A non-chlorine potassium peroxymonosulfate disinfectant was prepared. The disinfectant was prepared with potassium peroxymonosulfate as the main component and amino sulfonic acid and surfactant as the auxiliary materials. The stability of the sample aqueous solution was investigated by detecting the peroxide concentration of the sample aqueous solution for 0-6 hours, and the formula of disinfectant was determined by orthogonal test. The germicidal efficacy had been done against Escherichia coli, Staphylococcus aureus and Candida albicans. The results show that the peroxide concentration in 1% aqueous solution is stable within 6 hours. Under the condition of（20±1） ℃ water bath, the mean killing logarithmic values of 1% aqueous solution to Eescherichia coli and Staphylococcus aureus for 5 min are greater than 5.00; the mean killing logarithmic values of 2% aqueous solution acting on Candida albicans for 10 min are greater than 4.00. The active components of the non-chloride disinfectant prepared by potassium peroxymonosulfate and sulfamic acid are stable in aqueous solution and have ideal killing effect.

Key words: potassium peroxymonosulfate, disinfectant, sterilization

中图分类号:

R187

王展印,高文军,卫罡,张争明. 过硫酸氢钾复合物消毒剂的制备及杀菌性能研究[J]. 日用化学工业, 2019, 49(8): 515-518.

WANG Zhan-yin,GAO Wen-jun,WEI Gang,ZHANG Zheng-ming. Preparation and bactericidal properties of potassium peroxymonosulfate disinfectant[J]. China Surfactant Detergent & Cosmetics, 2019, 49(8): 515-518.

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水平	A w（氨基磺酸）/%	B w（柠檬酸）/%	C w（EDTA）/%	D w（TX-10）/%
1	12	11	0.5	0.4
2	14	13	1.0	0.8
3	16	15	1.5	1.2

序号	A	B	C	D	c（KHSO₅）/（mmol·L^-1）				RSD/%
序号	A	B	C	D	0 h	2 h	4 h	6 h	RSD/%
1 2 3 4 5 6 7 8 9	1 2 3 1 2 3 1 2 3	1 1 1 2 2 2 3 3 3	1 2 3 2 3 1 3 1 2	1 2 3 3 1 2 2 3 1	21.05 21.05 20.89 21.00 21.13 21.15 20.90 21.06 20.96	21.05 20.72 19.89 21.00 21.06 21.11 21.02 20.90 21.01	21.27 20.67 20.37 20.72 21.03 21.07 21.00 21.03 20.90	21.03 20.68 20.36 21.00 20.96 21.20 20.84 21.00 20.89	0.54 0.87 2.00 0.67 0.33 0.26 0.41 0.33 0.27
K₁	1.62	3.41	1.13	1.14
K₂	1.53	1.26	1.81	1.54
K₃	2.53	1.01	2.74	3.00
k₁	0.540 0	1.136 7	0.376 7	0.380 0
k₂	0.510 0	0.420 0	0.603 3	0.513 3
k₃	0.843 3	0.336 7	0.913 3	1.000 0
R	0.333 3	0.800 0	0.536 7	0.620 0

样品	c（KHSO₅）/（mmol·L^-1）				RSD/%
样品	0 h	2 h	4 h	6 h	RSD/%
1	20.96	20.88	20.97	20.86	0.27
2	21.06	21.08	21.05	20.98	0.21
3	20.93	21.02	20.95	20.86	0.31

组别	各组生长细菌数/（cfu·mL^-1）			平均生长菌落数/（cfu·mL^-1）
组别	1	2	3	平均生长菌落数/（cfu·mL^-1）
1	0	0	0	0
2	0	0	0	0
3	2.90×10⁶	3.45×10⁶	2.25×10⁶	2.87×10⁶
4	2.60×10⁶	2.65×10⁶	1.80×10⁶	2.35×10⁶
5	2.20×10⁶	3.75×10⁶	2.15×10⁶	2.70×10⁶

组别	各组生长细菌数/（cfu·mL^-1）			平均生长菌落数/（cfu·mL^-1）
组别	1	2	3	平均生长菌落数/（cfu·mL^-1）
1	000	000	000	000
2	250	465	135	283
3	2.60×10⁶	2.65×10⁶	2.00×10⁶	2.42×10⁶
4	2.65×10⁶	2.75×10⁶	2.45×10⁶	2.62×10⁶
5	3.25×10⁶	3.05×10⁶	2.90×10⁶	3.07×10⁶