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日用化学工业（中英文）

日用化学工业 ›› 2015, Vol. 45 ›› Issue (8): 439-442.doi: 10.13218/j.cnki.csdc.2015.08.005

• 开发与应用 • 上一篇    下一篇

反应性高分子灭菌剂的合成和对大肠杆菌的杀灭性能

鹿桂乾1, 张利萍1, 黄亮1, 符若文2   

  1. 1.广州立白企业集团有限公司 研发中心,广东 广州 510370;
    2.中山大学 化学与化学工程学院 材料科学研究所,广东 广州 510275
  • 收稿日期:2015-06-17 修回日期:2015-08-04 出版日期:2015-08-22 发布日期:2019-04-10
  • 作者简介:鹿桂乾(1979-),女,工程师,博士,电话:(020)81250596-8385,E-mail:lugq@liby.com.cn。

Synthesis and performance for sterilization of colon bacillus of reactive polymeric sterilants

LU Gui-qian1, ZHANG Li-ping1, HUANG Liang1, FU Ruo-wen2   

  1. 1.Research Development Center,Guangzhou Liby Enterprise Group Co.,Ltd.,Guangzhou,Guangdong 510370,China;
    2.Materials Science Institute,School of Chemistry and Chemical Engineering,Sun Yat-sen University, Guangzhou,Guangdong 510275,China
  • Received:2015-06-17 Revised:2015-08-04 Online:2015-08-22 Published:2019-04-10

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摘要： 通过甲基丙烯酰氧乙基二甲基十二烷基溴化铵(DMAEMA-DB)、丙烯酰胺(AAm)和马来酸酐(MAn)三元共聚,将马来酸酐活性基团和长链烷基季铵盐基团同时引入大分子链中,制备了一系列的反应性高分子灭菌剂Poly(DMAEMA-DB/AAm/MAn)。用FTIR和1HNMR等表征了其结构,用JIS法测定了其阳离子度;用平板活菌计数法对各种反应性高分子灭菌剂的灭菌活性分别进行了表征,并研究了灭菌单体用量、接触时间和高分子灭菌剂的质量浓度对灭菌活性的影响。结果表明:当马来酸酐的投料摩尔分数为15%,灭菌单体DMAEMA-DB的投料摩尔分数为7%~20%时,聚合物表现出较好的灭菌活性;0.5 g/L的Poly(DMAEMA-DB/AAm/MAn) (单体摩尔比为20/65/15)表现出了快速的灭菌能力。

关键词: 季铵盐, 反应性高分子灭菌剂, 灭菌活性

Abstract: A series of reactive polymeric sterilants,Poly(DMAEMA-DB/AAm/MAn) were synthesized by copolymerizing dimethylaminoethyl methacrylate dodecyl ammonium bromide (DMAEMA-DB),acrylamide (AAm) and maleic anhydride (MAn) to introduce reactive maleic anhydride groups and long alkyl quaternary ammonium salt groups into macromolecules.Their structures were characterized by FTIR and 1HNMR.The cation density was determined by JIS method.The sterilizing activities of the various reactive polymeric sterilants were measured by viable cell counting method.The effects of the dosage of sterilant monomer in feed,the contact time and the mass concentration of the polymeric sterilant on sterilizing activity were investigated.Results showed that the Poly(DMAEMA-DB/AAm/Man) exhibit rather high sterilizing activity when the mole fraction of MAn is 15% in the feed and the mole fraction of DMAEMA-DB is 7%~20% in the feed;Poly(DMAEMA-DB/AAm/MAn) with mass concentration of 0.5 g/L exhibits good sterilizing activity when mass ratio of the monomers DMAEMA-DB/AAm/MAn in the feed is at 20/65/15.

Key words: quaternary ammonium salts, reactive polymeric sterilant, sterilizing activities

中图分类号: 

  • TQ423.12