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日用化学工业（中英文）

日用化学工业（中英文） ›› 2026, Vol. 56 ›› Issue (6): 811-820.doi: 10.3969/j.issn.2097-2806.2026.06.014

• 分析与检测 • 上一篇    下一篇

基于顶空-气相-离子迁移谱和顶空-气相-质谱技术的化妆品真伪性鉴别研究

高丽琼,沈国芳*(),张伟,王秀秀,徐悦,汪霞   

  1. 杭州食品药品检验科学研究院， 浙江 杭州 310023
  • 收稿日期:2025-09-02 修回日期:2026-06-02 出版日期:2026-06-22 发布日期:2026-07-22
  • 基金资助:
    浙江省药品监管系统科技计划资助项目(2024025);浙江省药品监管系统科技计划资助项目(2024001);浙江省药品监管系统科技计划资助项目(2023031);国家药品标准制修订研究课题(2025H25);国家药品标准制修订研究课题(2025H51)

Authenticity identification of cosmetics based on headspace-gas chromatography-ion mobility spectrometry and headspace-gas chromatography-mass spectrometry technologies

Liqiong Gao,Guofang Shen*(),Wei Zhang,Xiuxiu Wang,Yue Xu,Xia Wang   

  1. Hangzhou Institute for Food and Drug Control, Hangzhou, Zhejiang 310023, China
  • Received:2025-09-02 Revised:2026-06-02 Online:2026-06-22 Published:2026-07-22
  • Contact: *E-mail: shengf@126.com

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摘要：

以水剂、乳液和膏霜三类化妆品为研究对象，结合顶空-气相色谱-离子迁移谱（HS-GC-IMS）与顶空-气相色谱-质谱（HS-GC-MS）技术，构建了不同真伪化妆品挥发性有机物（VOCs）的指纹图谱，系统分析其挥发性有机成分差异，以实现对真伪化妆品的准确鉴别。通过HS-GC-IMS技术，分别从三类样品中识别出91种、37种和37种有效成分，并进一步鉴定出83种、30种和23种化合物；指纹图谱相似度分析显示，正品相似度分别高于85%，93%和91%，而伪品则分别低于64%，31%和43%。基于HS-GC-MS总离子流图数据，采用中药色谱指纹图谱相似度评价系统进行分析，正品相似度范围为0.968~0.999，伪品为0.003~0.849。两种分析方法均能有效区分真伪化妆品。研究表明，HS-GC-MS与HS-GC-IMS联用可实现对化妆品挥发性有机成分的全面对比分析，为化妆品真伪鉴别提供了一种快速、准确的技术手段，并为化妆品真伪鉴别奠定了科学基础。

关键词: 化妆品, 顶空-气相色谱-离子迁移谱, 顶空-气相色谱-质谱, 挥发性有机物质, 真伪鉴别

Abstract:

Focusing on toner, lotion and cream matrices, the fingerprints of volatile organic compounds were constructed to characterize the differences among various cosmetics, and achieve accurate authenticity identification. A combined approach utilizing headspace-gas chromatography-ion mobility spectrometry （HS-GC-IMS） and headspace-gas chromatography-mass spectrometry （HS-GC-MS） technologies was used to detect differences between genuine and counterfeit cosmetics. The HS-GC-IMS spectra were processed using the built-in NIST and IMS databases to reveal 91, 37, and 37 active ingredients, respectively, from which 83, 30, and 23 compounds are identified. The Gallery Plot plugin was used for fingerprint analysis; the similarity results show that the similarities for genuine products are greater than 85%, 93%, and 91%, respectively, while those for the counterfeit products are less than 64%, 31%, and 43%, respectively. Furthermore, HS-GC-IMS data were analyzed using the traditional Chinese medicine chromatographic fingerprint similarity evaluation system based on total ion chromatogram data. The similarity between genuine products ranged from 0.968 to 0.999, while those between counterfeit products range from 0.003 to 0.849. Both methods proved highly effective in distinguishing between genuine and counterfeit cosmetics. Therefore, the combination of HS-GC-MS and HS-GC-IMS technologies can be successfully applied to the comparative analysis of organic volatile components in genuine and counterfeit cosmetics, enabling rapid and accurate authentication, and providing scientific basis for cosmetic authenticity authentication studies.

Key words: cosmetics, headspace-gas chromatography-ion mobility spectrometry, headspace-gas chromatography-mass spectrometry, volatile organic compounds, authenticity identification

中图分类号: 

  • TQ658