乙酰基四肽-11防脱发作用的研究

doi:10.3969/j.issn.2097-2806.2023.11.008

日用化学工业（中英文） ›› 2023, Vol. 53 ›› Issue (11): 1293-1298.doi: 10.3969/j.issn.2097-2806.2023.11.008

乙酰基四肽-11防脱发作用的研究

石莲莲¹,马文君¹,孙亚萍¹,王培培^1,^*(),郑春阳^1,²

1.天津强微特生物科技有限公司，天津 300384
2.守正创新生物科技（天津）有限公司，天津 300308

收稿日期:2022-10-13 修回日期:2023-10-25 出版日期:2023-11-22 发布日期:2023-11-21
基金资助:
科技重大专项与工程-生物医药产业链创新专项(21ZXSYSY00010)

Study on the effect of acetyl tetrapeptide-11 in preventing hair loss

Shi Lianlian¹,Ma Wenjun¹,Sun Yaping¹,Wang Peipei^1,^*(),Zheng Chunyang^1,²

1. Robustnique Corporation Ltd., Tianjin 300384, China
2. Integribiotech Corporation Ltd., Tianjin 300308, China

Received:2022-10-13 Revised:2023-10-25 Online:2023-11-22 Published:2023-11-21
Contact: *Tel.: +86-22-83718165, E-mail: peipei.wang@robustnique.com.

摘要/Abstract

摘要：

将乙酰基四肽-11应用于小鼠进行脱发研究。通过对C57BL/6雌性小鼠背部进行脱毛处理，实验组连续涂抹3个质量浓度梯度（10，20和30 μg/mL）的乙酰基四肽-11水溶液18天，对照组涂抹生理盐水，观察小鼠背部毛发生长情况，HE染色进行组织学分析，并初步进行了志愿者试用评估。结果表明，一定质量浓度的乙酰基四肽-11可以预防小鼠脱发，避免毛囊微型化，同时可以维持小鼠表皮紧致。志愿者试用评估表明测试样品对所有志愿者都有防脱发效果，85%志愿者反馈头发密度变大。

关键词: 乙酰基四肽-11, ⅩⅤⅡ型胶原, 脱发, 毛囊干细胞

Abstract:

In recent years, the research on hair loss has become more and more intensive. In this work, acetyl tetrapeptide-11 was applied in mice to study its effect on hair loss. After depilation treatment on the back of eight C57BL/6 female mice, the experimental group was continually smeared with aqueous solutions of acetyl tetrapeptide-11 with different mass concentrations （10, 20 and 30 μg/mL） for 18 days, while the control group was smeared with normal saline. The hair growth on the back of mice was observed, and HE staining was used for histological analysis. The efficacy on human volunteers was also preliminarily evaluated. The results on mice showed that a certain mass concentration of acetyl tetrapeptide-11 could prevent hair loss and avoid the miniaturization of hair follicles and maintain epidermis firmness. The results on human volunteers showed that, the test samples had prevention effect on hair loss for all volunteers, and 85% of the volunteers gave feedback to denser hair. This study could provide a new solution and theoretical basis for hair loss prevention.

Key words: acetyl tetrapeptide-11, ⅩⅤⅡ collagen, hair loss, follicle stem cell

中图分类号:

TQ658

石莲莲, 马文君, 孙亚萍, 王培培, 郑春阳. 乙酰基四肽-11防脱发作用的研究[J]. 日用化学工业（中英文）, 2023, 53(11): 1293-1298.

Shi Lianlian, Ma Wenjun, Sun Yaping, Wang Peipei, Zheng Chunyang. Study on the effect of acetyl tetrapeptide-11 in preventing hair loss[J]. China Surfactant Detergent & Cosmetics, 2023, 53(11): 1293-1298.

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	第8天		第19天
	对照组	实验组	对照组	实验组
10 μg/mL	104.00±18.32	110.61± 8.29	21.31±4.83	31.37±4.23
20 μg/mL	83.65± 8.27	70.61±10.32	25.64±2.86	73.26±8.54^**
30 μg/mL	74.29±14.85	82.14±13.47	35.33±5.94	83.67±6.91^**

乙酰基四肽-11防脱发作用的研究

Study on the effect of acetyl tetrapeptide-11 in preventing hair loss

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