日用化学工业(中英文) ›› 2023, Vol. 53 ›› Issue (11): 1273-1279.doi: 10.3969/j.issn.2097-2806.2023.11.005
收稿日期:
2023-01-21
修回日期:
2023-10-19
出版日期:
2023-11-22
发布日期:
2023-11-21
基金资助:
Wang Tao*(),Sun Xiao,Li Zhuo,Dong Manman,Jia Hanbing,Wei Xinghua
Received:
2023-01-21
Revised:
2023-10-19
Online:
2023-11-22
Published:
2023-11-21
Contact:
*Tel.: +86-13310900720, E-mail: 摘要:
考察了原料投料比、不同溶剂、碱性试剂及反应时间等条件对反应收率的影响,对乙酰香兰素合成工艺优化及反应进程进行了研究。实验以香兰素和乙酸酐为原料,反应合成乙酰香兰素。采用毛细管熔点法、傅里叶变换红外光谱(FT-IR)及气相色谱-质谱/质谱(GC-MS/MS)对乙酰香兰素反应进行分析和表征。实验结果表明,乙酰香兰素的合成工艺优化条件为原料摩尔比n(香兰素):n(乙酸酐):n(三乙胺)=1:1.3:0.5,室温反应0.5 h,收率可达99.0%。初步探讨了碱性试剂三乙胺作为催化剂在反应进程当中所起的催化作用,并对其反应机理进行了推测。该工艺反应条件温和,反应时间短,收率高,原料价廉易得,操作简单易行。乙酰香兰素反应进程的研究为合成工艺优化、分析检测方法及基础理论研究提供了一定的参考依据。
中图分类号:
王涛, 孙晓, 李卓, 董曼曼, 贾寒冰, 卫星华. 乙酰香兰素合成工艺优化及反应进程分析[J]. 日用化学工业(中英文), 2023, 53(11): 1273-1279.
Wang Tao, Sun Xiao, Li Zhuo, Dong Manman, Jia Hanbing, Wei Xinghua. Optimization of synthesis process of acetylvanillin and analysis of the reaction process[J]. China Surfactant Detergent & Cosmetics, 2023, 53(11): 1273-1279.
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